Compare Prempro vs. Evamist

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Prempro
(conjugated estrogens / medroxyprogesterone acetate)

Evamist
(estradiol spray)

Coming soon.Relieves hot flashes due to menopause. Evamist (Estradiol Spray) is easy to use, absorbs well into your skin without needing to rub it in, and is a good option if you don’t want to use estrogen pills or patches.
Reviews & ratings
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Have you used Prempro (conjugated estrogens / medroxyprogesterone acetate)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Evamist (estradiol spray)?
Worth itNot sureNot worth it
Side effects
PremproEvamist

We haven’t found good data for Prempro side effects.

FDA side effect reports for Prempro »
  • Headache 3%
  • Breast tenderness 4%
  • Nasopharyngitis (common cold) 3%
  • Nipple pain 2%
  • Back pain 1%
  • Nausea 1%
  • Arthralgia (joint pain) 3%
More Evamist side effects »
How it works
PremproEvamist
Coming soon.Evamist (Estradiol Spray) replaces estrogen hormones in your vagina that your body loses during menopause. Estrogen helps relieve symptoms of menopause, such as hot flashes, night sweats, and vaginal problems.
Type of medication
PremproEvamist
Prescription only
Available as
PremproEvamist
  • Pill
  • Spray
Used for
PremproEvamist
  • Menopause Moderate To Severe Abnormal Vasomotor Function Menopause Moderate To Severe Vaginal Atrophy Moderate To Severe Vulvar Atrophy Postmenopausal Osteoporosis
  • Hot Flashes And Night Sweats
Risk factors for serious side effects
PremproEvamist
    Coming soon.
    • Using estrogen for more than one year
    • Personal or family history of breast cancer
    • Duration of use
    • Personal or family history of blood clots
    • Obesity
    Detailed Evamist (estradiol spray) risks & warnings »
    Pregnancy

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    Alcohol
    PremproEvamist
    No alcohol related info.
    • The spray is alcohol-based and flammable, so you shouldn't smoke while applying it.
    Weight
    PremproEvamist
    No weight related info.
    • Can cause nausea, dizziness, bloating, and breast tenderness.
    Upsides and benefits
    PremproEvamist
    Coming soon
    • Evamist (Estradiol Spray) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, vaginal dryness, low energy).
    • Dries faster than topical estrogen gels.
    • Good for people who don't want to take daily pills.
    • Fewer side effects than pills since lower amounts of estrogen are used in topical sprays.
    • Women in studies have seen the severity and number of hot flashes lower by half within 4 weeks of using Evamist (Estradiol Spray).
    • Very few women had skin irritation from the medicine.
    • Depending on your symptoms, your dose may change, but you can still use the same spray pump no matter what your dose is.
    • Can lower your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
    Downsides and risks
    PremproEvamist
    Coming soon
    • Increases your risk of endometrial and breast cancer.
    • If you have your uterus, you have to use Evamist (Estradiol Spray) with another hormone called progestin to lower your risk of uterine cancer.
    • Increases your risk of developing blood clots and stroke.
    • Can't be used in people with liver problems.
    • It's possible to expose other people to the estrogen before it's absorbed by your skin.
    • Can be expensive since it's only available as a brand name product.
    Tips from our pharmacists for people taking the medication
    PremproEvamist
    Coming soon
    • Spray with the container upright and the cone flat against your skin on the inside of your forearm. If more than one spray is needed, always use a different area on your forearm.
    • Don't put it on your face, breasts, vagina, or irritated skin.
    • Don't rub it in. Let the spray dry for about 2 minutes before dressing, and don't get the application site wet for at least 1 hour.
    • Can cause nausea, dizziness, bloating, and breast tenderness.
    • Tell your doctor about any unusual vaginal bleeding.
    • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
    • The spray is alcohol-based and flammable, so you shouldn't smoke while applying it.
    Learn more
    More about PremproSide effectsReviews & ratingsFDA package insert
    Have you used Prempro (conjugated estrogens / medroxyprogesterone acetate)?
    Worth itNot sureNot worth it
    More about EvamistSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Evamist (estradiol spray)?
    Worth itNot sureNot worth it