Compare Prempro vs. Provera

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Prempro
(conjugated estrogens / medroxyprogesterone acetate)

Provera
(medroxyprogesterone)

Coming soon.Regulates your menstrual cycle and supplements estrogen treatments for menopause. Provera (Medroxyprogesterone) works well to regulate your menstrual cycle and stop irregular bleeding. It also protects the uterus from estrogen's harmful effects.
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Coupons for Prempro
Best available price for 28 (28 tablets of 0.3mg/1.5mg) packages of prempro
Coupons for Provera
Best available price for 10 (10mg) tablets of provera
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Prempro (conjugated estrogens / medroxyprogesterone acetate)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Provera (medroxyprogesterone)?
Worth itNot sureNot worth it
Side effects
PremproProvera

We haven’t found good data for Prempro side effects.

FDA side effect reports for Prempro »

We haven’t found good data for Provera side effects.

FDA side effect reports for Provera »
How it works
PremproProvera
Coming soon.Provera (Medroxyprogesterone) contains medroxyprogesterone, a progesterone hormone that works to balance hormone changes in the body. In premenopausal women, it prevents thickening of the uterus lining and regulates your menstrual cycle. It's also added to hormone therapy to protect the uterus from the harmful effects of estrogen.
Type of medication
PremproProvera
Prescription only
Available as
PremproProvera
  • Pill
  • Pill
Used for
PremproProvera
  • Menopause Moderate To Severe Abnormal Vasomotor Function Menopause Moderate To Severe Vaginal Atrophy Moderate To Severe Vulvar Atrophy Postmenopausal Osteoporosis
  • Amenorrhea
Risk factors for serious side effects
PremproProvera
    Coming soon.
    • Personal or family history of breast cancer
    • Family history of ovarian cancer
    • Personal or family history of blood clots
    • Smoking
    • Obesity
    Detailed Provera (medroxyprogesterone) risks & warnings »
    Pregnancy

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    Weight
    PremproProvera
    No weight related info.
    • Provera (Medroxyprogesterone) contains progestin. It could cause a higher risk of ovarian cancer, especially if you have a family history of it. Your doctor can help you weigh the risks versus the benefits of this medication.
    • Can cause headache, weight gain, breast tenderness, or changes in mood.
    Upsides and benefits
    PremproProvera
    Coming soon
    • Provera (Medroxyprogesterone) can be used to treat multiple hormone problems in women.
    • After menopause, taking estrogen raises your risk of uterine cancer. However, taking progesterone, like in Provera (Medroxyprogesterone), along with estrogen gives you the positive effects of estrogen, but also prevents it from damaging your uterus.
    • Women taking an estrogen/progestin combination medications have a lower risk of uterine cancer.
    Downsides and risks
    PremproProvera
    Coming soon
    • You can't take Provera (Medroxyprogesterone) if you've had a hysterectomy (your uterus removed). You also can't take it if you're pregnant or breastfeeding, have unusual vaginal bleeding, or have a history of blood clots, certain kinds of cancer, stroke, heart attack, liver problems, or bleeding problems.
    Tips from our pharmacists for people taking the medication
    PremproProvera
    Coming soon
    • The dose of Provera (Medroxyprogesterone) will be different depending on what you’re using it for, so take it exactly the way your doctor tells you.
    • Talk to your doctor every few months about using the lowest possible dose of Provera (Medroxyprogesterone). Since there can be a lot of long-term side effects, take it only as long as you need it.
    • Can cause headache, weight gain, breast tenderness, or changes in mood.
    • If you're taking Provera (Medroxyprogesterone) to regulate your period, you'll get withdrawal bleeding 3 to 7 days after stopping Provera (Medroxyprogesterone).
    Learn more
    More about PremproSide effectsReviews & ratingsFDA package insert
    Have you used Prempro (conjugated estrogens / medroxyprogesterone acetate)?
    Worth itNot sureNot worth it
    More about ProveraSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Provera (medroxyprogesterone)?
    Worth itNot sureNot worth it