Compare Prempro vs. Vivelle-Dot

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Coming soon.

Prempro
(Conjugated Estrogens / Medroxyprogesterone Acetate)

Vivelle-Dot
(Estradiol Patch)

Coming soon.Treats low estrogen, relieves menopause symptoms, and lowers your risk of osteoporosis. The Vivelle-Dot (Estradiol Patch) needs to be replaced twice a week, but it comes in more strengths than other patches. It may have fewer side effects than oral estrogen pills.
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Reviews & ratings
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Have you used Prempro (Conjugated Estrogens / Medroxyprogesterone Acetate)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Vivelle-Dot (Estradiol Patch)?
Worth itNot sureNot worth it
Side effects
PremproVivelle-Dot

We haven’t found good data for Prempro side effects.

FDA side effect reports for Prempro »
  • Headache 26%
  • Low mood disorder 7%
  • Weight increased 7%
  • Vaginal bleeding between periods 6%
  • Sinus headache 6%
  • Common cold 5%
  • Ear, nose, or throat infection 5%
  • Back pain 5%
  • Neck pain 5%
  • Constipation 4%
More Vivelle-Dot side effects »
How it works
PremproVivelle-Dot
Coming soon.The Vivelle-Dot (Estradiol Patch) replaces an estrogen hormone, estradiol, that your body loses during and after menopause. Higher levels of estradiol relieve symptoms of low estrogen and menopause and prevent bone loss.
Type of medication
PremproVivelle-Dot
Coming soon.
Hormone replacement
Estrogen derivative
Prescription only
Available as
PremproVivelle-Dot
  • Pill
  • Patch
Used for (click to learn more)
PremproVivelle-Dot
  • Menopause - Moderate to severe abnormal vasomotor function Menopause - Moderate to severe vaginal atrophy - Moderate to severe vulvar atrophy Postmenopausal osteoporosis
  • Hot flashes and night sweats
Risk factors for serious side effects
PremproVivelle-Dot
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
Detailed risks & warnings »
Pregnancy

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Weight
PremproVivelle-Dot
No weight related info.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
Upsides and benefits
PremproVivelle-Dot
Coming soon
  • Comes in 4 different strengths.
  • The Vivelle-Dot (Estradiol Patch) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen, like hot flashes and vaginal dryness.
  • The patch is good for people who don't want to take daily pills.
  • Can be worn while swimming, bathing, and showering.
  • By using a patch instead of a pill, there's a lower risk of side effects such as blood clots and stroke since lower amounts of estrogen are used in patches.
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
  • Improves mood, energy, and mental alertness for some people.
Downsides and risks
PremproVivelle-Dot
Coming soon
  • You need to replace the Vivelle-Dot (Estradiol Patch) twice a week, compared to other patches that are once a week.
  • Patch can fall off.
  • Increases your risk of uterine and breast cancer.
  • If you have your uterus, you have to use the Vivelle-Dot (Estradiol Patch) with another hormone called progestin to lower your risk of uterine cancer.
  • Increases your risk of developing blood clots and stroke.
  • Can worsen other health conditions, like high cholesterol, asthma, diabetes, fluid retention, and migraines.
  • Can't be used in people with liver problems.
Tips from our pharmacists for people taking the medication
PremproVivelle-Dot
Coming soon
  • Remove the patch by tearing the package by hand and not with scissors. Never cut the patch.
  • Apply the sticky side of the patch to clean, dry, hairless skin below your waistline on areas as instructed by the manufacturer (never on your breast).
  • Replace the patch twice a week (every 3-4 days) on a different area of your skin to lower your risk of skin irritation.
  • Fold together the sticky sides of used patches before throwing them away to avoid exposing others to the medicine. Don't flush them down the toilet.
  • Shouldn't be used forever. Talk to your doctor regularly to see if you still need treatment.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Tell your doctor about any unusual vaginal bleeding.
  • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
Learn more
More about PremproSide effectsReviews & ratingsFDA package insert
Have you used Prempro (Conjugated Estrogens / Medroxyprogesterone Acetate)?
Worth itNot sureNot worth it
More about Vivelle-DotSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Vivelle-Dot (Estradiol Patch)?
Worth itNot sureNot worth it