Compare Prevacid vs. Alka-Seltzer

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Prevacid
(lansoprazole)

Alka-Seltzer Original
(aspirin / citric acid / sodium bicarbonate)

Treats heartburn and stomach ulcers. Prevacid (Lansoprazole) gives you long-lasting heartburn relief and helps heal ulcers.Relieves heartburn, headache, and body pains. Alka-Seltzer Original (Aspirin / Citric Acid / Sodium Bicarbonate) gives quick relief for headache, body pains, and upset tummies, but might be hard to swallow if you don't like the taste or fizz.
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Best available price for 30 (30mg) capsules of lansoprazole
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Reviews & ratings
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5.48Prevacid
Reviews for Prevacid (lansoprazole)
71%
of people (All ages) say Prevacid (lansoprazole) is worth it
71%
say it works well
19%
say it's a big hassle
Have you used Prevacid (lansoprazole)?
Worth itNot sureNot worth it
Reviews for Alka-Seltzer Original (aspirin / citric acid / sodium bicarbonate)
81%
+10% better vs. Prevacid (lansoprazole)
52%
-19% worse vs. Prevacid (lansoprazole)
8%
+11% better vs. Prevacid (lansoprazole)
1055 reviews
Have you used Alka-Seltzer Original (aspirin / citric acid / sodium bicarbonate)?
Worth itNot sureNot worth it
Side effects
PrevacidAlka-Seltzer
  • Diarrhea 2%
  • Abdominal pain 1%
More Prevacid side effects »

We haven’t found good data for Alka-Seltzer side effects.

FDA side effect reports for Alka-Seltzer »
How it works
PrevacidAlka-Seltzer
Prevacid (Lansoprazole) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach, treats heartburn, and heals ulcers.Alka-Seltzer Original (Aspirin / Citric Acid / Sodium Bicarbonate) is a combination medicine. Sodium bicarbonate is an antacid that relieves heartburn and acid tummy (indigestion). Aspirin is a pain reliever that treats headache and body pains.
Type of medication
PrevacidAlka-Seltzer
Prescription or OTC
Over-the-counter
Available as
PrevacidAlka-Seltzer
  • Extended release
  • Dissolving tablet extended release
  • Chewable tablet
  • Effervescent tablet
Used for
PrevacidAlka-Seltzer
Risk factors for serious side effects
PrevacidAlka-Seltzer
  • Helicobacter pylori infection
  • Autoimmune disease
  • Being hospitalized
  • Antibiotic use
  • Osteoporosis
Detailed Prevacid (lansoprazole) risks & warnings »
  • Current kidney disease
  • Kidney dialysis
  • Age 65 or older
  • Congestive heart failure (CHF)
  • High blood pressure
Detailed Alka-Seltzer Original (aspirin / citric acid / sodium bicarbonate) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Interactions
PrevacidAlka-Seltzer
  • Can interact with other drugs, so be sure your doctor knows all the medicine you're taking before starting Prevacid (Lansoprazole).
  • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Prevacid (Lansoprazole).
No interactions related info.
Food
PrevacidAlka-Seltzer
  • Take Prevacid (Lansoprazole) about 1 hour before a meal.
  • Take it with food to lower the chance of an upset stomach.
Kidneys and liver
PrevacidAlka-Seltzer
No kidneys and liver related info.
  • If you have kidney or hyperparathyroid disease Alka-Seltzer Original (Aspirin / Citric Acid / Sodium Bicarbonate) can build up in your blood. This may can cause toxic levels of sodium in your body. This is more likely if you have severe kidney disease (defined as a kidney function blood test called GFR of less than 30ml/min). If you have severe kidney disease or are on kidney dialysis don't use Alka-Seltzer Original (Aspirin / Citric Acid / Sodium Bicarbonate); a different antacid would be better for you.
Upsides and benefits
PrevacidAlka-Seltzer
  • Most people can take Prevacid (Lansoprazole) without any noticeable day-to-day side effects.
  • Prevacid (Lansoprazole) lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • Available as both a generic and over-the-counter option, so it's pretty affordable.
  • Sometimes if one PPI doesn't work, another medication in the same class will work for you.
  • Works great if you have an upset stomach and a headache or body pain at the same time.
  • Works really fast.
  • Available over the counter without a prescription.
  • Cheap.
Downsides and risks
PrevacidAlka-Seltzer
  • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
  • Depending on the condition you are treating, it can take one to two weeks to get the full effect.
  • If you are taking Prevacid (Lansoprazole) for a long time you should take a calcium supplement to prevent fragile bones.
  • Can interact with other drugs, so be sure your doctor knows all the medicine you're taking before starting Prevacid (Lansoprazole).
  • Doesn't last very long.
  • Other antacids like Zantac (H2 blockers) and omeprazole (proton pump inhibitors) can work better and last longer.
  • Because it has aspirin in it, it increases the risk of bleeding, especially if you take any other blood thinning medicine.
  • Can't be used by people with allergy to aspirin.
  • You may not like the taste or fizz.
Tips from our pharmacists for people taking the medication
PrevacidAlka-Seltzer
  • Take Prevacid (Lansoprazole) about 1 hour before a meal.
  • Don't chew or crush capsules, but swallow them whole.
  • If you have trouble swallowing, there's a tablet available that dissolves in your mouth.
  • Give Prevacid (Lansoprazole) a chance to work. You'll see some benefits right away, but the full effects can take a week or so to kick in.
  • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Prevacid (Lansoprazole).
  • Don't take Alka-Seltzer if you're allergic to aspirin.
  • Take it with food to lower the chance of an upset stomach.
  • This medicine isn't recommended for kids 12 and younger because it has aspirin in it.
  • Stop taking this right away and talk to your doctor if you have ringing in your ears, rash, trouble breathing, unusual bleeding, or nausea or vomiting that doesn't go away.
  • Having a dental or medical procedure? You may need to stop taking this before the big day. Ask your dentist or doctor.
  • Alka-Seltzer contains sodium. If you need to follow a low sodium diet a different medication would be better for you.
  • Not a good choice if you have stomach bleeding, bleeding problems, diabetes, or gout, or if you're taking medicines to thin your blood.
Learn more
More about PrevacidSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Prevacid (lansoprazole)?
Worth itNot sureNot worth it
More about Alka-SeltzerSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Alka-Seltzer Original (aspirin / citric acid / sodium bicarbonate)?
Worth itNot sureNot worth it