Compare Prevacid vs. Alka-Seltzer

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Prevacid
(lansoprazole)

Alka-Seltzer Original
(aspirin / citric acid / sodium bicarbonate)

Treats heartburn and stomach ulcers. Prevacid (lansoprazole) is an effective and inexpensive acid reducer commonly used to provide heartburn relief and help heal ulcers.Relieves heartburn, headache, and body pains. Alka-Seltzer Original (Aspirin / Citric Acid / Sodium Bicarbonate) gives quick relief for headache, body pains, and upset tummies, but might be hard to swallow if you don't like the taste or fizz.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.48Prevacid
Reviews for Prevacid
71%
of people (All ages) say Prevacid is worth it
71%
say it works well
19%
say it's a big hassle
Have you used Prevacid (lansoprazole)?
Worth itNot sureNot worth it
Reviews for Alka-Seltzer
81%
-10% worse vs. Prevacid
52%
+19% better vs. Prevacid
8%
-11% worse vs. Prevacid
1055 reviews
Have you used Alka-Seltzer Original (aspirin / citric acid / sodium bicarbonate)?
Worth itNot sureNot worth it
Side effects
PrevacidAlka-Seltzer
  • Diarrhea 2%
  • Abdominal pain 1%
More Prevacid side effects »

We haven’t found good data for Alka-Seltzer side effects.

FDA side effect reports for Alka-Seltzer »
How it works
PrevacidAlka-Seltzer
Prevacid (lansoprazole) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach by blocking the final step of stomach acid production.Alka-Seltzer Original (Aspirin / Citric Acid / Sodium Bicarbonate) is a combination medicine. Sodium bicarbonate is an antacid that relieves heartburn and acid tummy (indigestion). Aspirin is a pain reliever that treats headache and body pains.
Type of medication
PrevacidAlka-Seltzer
Prescription or OTCOver-the-counter
Available as
PrevacidAlka-Seltzer
  • Extended release
  • Dissolving tablet extended release
  • Liquid
  • Chewable tablet
  • Effervescent tablet
Used for
PrevacidAlka-Seltzer
Risk factors for serious side effects
PrevacidAlka-Seltzer
  • High dose Prevacid (lansoprazole)
  • Long-term treatment with Prevacid (lansoprazole)
  • Low bone mineral density
  • Older age
Detailed Prevacid (lansoprazole) risks & warnings »
  • Current kidney disease
  • Kidney dialysis
  • Age 65 or older
  • Congestive heart failure (CHF)
  • High blood pressure
Detailed Alka-Seltzer Original (aspirin / citric acid / sodium bicarbonate) risks & warnings »
Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Price
PrevacidAlka-Seltzer
  • Prevacid (lansoprazole) is available over-the-counter and as inexpensive, generic options.
No price related info.
Interactions
PrevacidAlka-Seltzer
  • Some prescription drugs can interact with Prevacid (lansoprazole), so talk to your doctor or pharmacist about the medicines you are taking.
No interactions related info.
Food
PrevacidAlka-Seltzer
No food related info.
  • Take it with food to lower the chance of an upset stomach.
Kidneys and liver
PrevacidAlka-Seltzer
  • Prevacid (lansoprazole) can cause acute kidney damage that can occur at any time during treatment. Stop taking Prevacid (lansoprazole) and speak to your doctor immediately if you notice blood in the urine, changes in urine output, swelling of the body, weight gain, fever, or confusion.
  • If you have kidney or hyperparathyroid disease Alka-Seltzer Original (Aspirin / Citric Acid / Sodium Bicarbonate) can build up in your blood. This may can cause toxic levels of sodium in your body. This is more likely if you have severe kidney disease (defined as a kidney function blood test called GFR of less than 30ml/min). If you have severe kidney disease or are on kidney dialysis don't use Alka-Seltzer Original (Aspirin / Citric Acid / Sodium Bicarbonate); a different antacid would be better for you.
Upsides and benefits
PrevacidAlka-Seltzer
  • Most people can take Prevacid (lansoprazole) without any noticeable day-to-day side effects.
  • Comes in a dissolving tablet to be placed on the tongue if you cannot or do not like to swallow pills.
  • Prevacid (lansoprazole) lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once a day.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • Prevacid (lansoprazole) is available over-the-counter and as inexpensive, generic options.
  • Works great if you have an upset stomach and a headache or body pain at the same time.
  • Works really fast.
  • Available over the counter without a prescription.
  • Cheap.
Downsides and risks
PrevacidAlka-Seltzer
  • Doesn't start working right away like some other acid reducers (Tums, Rolaids, or Maalox).
  • May not be the best choice for patients 65 years of age and older due to risk of bone fractures and C. diff infection (bacterial).
  • Is used if you have frequent heartburns that occur more than 2 days per week. Speak to your doctor or pharmacist if you only have occasional heartburn.
  • Doesn't last very long.
  • Other antacids like Zantac (H2 blockers) and omeprazole (proton pump inhibitors) can work better and last longer.
  • Because it has aspirin in it, it increases the risk of bleeding, especially if you take any other blood thinning medicine.
  • Can't be used by people with allergy to aspirin.
  • You may not like the taste or fizz.
Tips from our pharmacists for people taking the medication
PrevacidAlka-Seltzer
  • Take Prevacid (lansoprazole) with a full glass of water before eating.
  • Starts working in 1 to 3 hours. It can take 1 to 4 days to take full effect.
  • Some prescription drugs can interact with Prevacid (lansoprazole), so talk to your doctor or pharmacist about the medicines you are taking.
  • Do not take for more than 14 days, unless directed by your doctor. Speak to your doctor if your symptoms don't go away after 2 weeks.
  • Prevacid (lansoprazole) capsules can be opened and sprinkled on 1 tablespoon of applesauce, cottage cheese, or yogurt. Swallow immediately after. The dissolving tablets shouldn't be swallowed, broken, or chewed.
  • Don't take Alka-Seltzer if you're allergic to aspirin.
  • Take it with food to lower the chance of an upset stomach.
  • This medicine isn't recommended for kids 12 and younger because it has aspirin in it.
  • Stop taking this right away and talk to your doctor if you have ringing in your ears, rash, trouble breathing, unusual bleeding, or nausea or vomiting that doesn't go away.
  • Having a dental or medical procedure? You may need to stop taking this before the big day. Ask your dentist or doctor.
  • Alka-Seltzer contains sodium. If you need to follow a low sodium diet a different medication would be better for you.
  • Not a good choice if you have stomach bleeding, bleeding problems, diabetes, or gout, or if you're taking medicines to thin your blood.
Learn more
More about PrevacidSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Prevacid (lansoprazole)?
Worth itNot sureNot worth it
More about Alka-SeltzerSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Alka-Seltzer Original (aspirin / citric acid / sodium bicarbonate)?
Worth itNot sureNot worth it