Compare Prevacid vs. Omeprazole

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Prevacid
(lansoprazole)

Prilosec
(omeprazole)

Treats heartburn and stomach ulcers. Prevacid (Lansoprazole) gives you long-lasting heartburn relief and helps heal ulcers.Treats heartburn and stomach ulcers. Prilosec (Omeprazole) gives you long-lasting heartburn relief. Choose the cheapest proton pump inhibitor because they all work equally well for heartburn.
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Prices and coupon for 30 (30mg) capsules of lansoprazole
Coupons for
Prices and coupon for 30 (20mg) capsules of omeprazole
Reviews & ratings
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Have you used Prevacid (lansoprazole)?
Worth itNot sureNot worth it
Reviews for Prilosec (omeprazole)
80%
+9% better vs. Prevacid (lansoprazole)
59%
-12% worse vs. Prevacid (lansoprazole)
8%
+11% better vs. Prevacid (lansoprazole)
1167 reviews
Have you used Prilosec (omeprazole)?
Worth itNot sureNot worth it
Side effects
PrevacidOmeprazole
  • Diarrhea 2%
  • Abdominal pain 1%
More Prevacid side effects »
  • Upper respiratory infection 75%
  • Fever 33%
  • Headache 7%
  • Abdominal pain 5%
  • Nausea 4%
  • Diarrhea 4%
  • Accidental injuries 4%
  • Passing gas 3%
  • Vomiting 3%
More Omeprazole side effects »
How it works
PrevacidOmeprazole
Prevacid (Lansoprazole) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach, treats heartburn, and heals ulcers.Prilosec (Omeprazole) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach, treats heartburn, and heals ulcers.
Type of medication
PrevacidOmeprazole
Prescription or OTC
Prescription or OTC
Available as
PrevacidOmeprazole
  • Extended release
  • Dissolving tablet extended release
  • Extended release
Used for
PrevacidOmeprazole
Risk factors for serious side effects
PrevacidOmeprazole
    • Helicobacter pylori infection
    • Autoimmune disease
    • Being hospitalized
    • Antibiotic use
    • Osteoporosis
    • Age 50 or older
    • Using high medication doses
    • Long-term therapy (1 year or more)
    • Smoking
    • Use of other medications that weaken bones
      Detailed Prevacid (lansoprazole) risks & warnings »
        • Helicobacter pylori infection
        • Autoimmune disease
        • Being hospitalized
        • Antibiotic use
        • Osteoporosis
        • Age 50 or older
        • Using high medication doses
        • Long-term therapy (1 year or more)
        • Smoking
        • Use of other medications that weaken bones
          Detailed Prilosec (omeprazole) risks & warnings »
          Pregnancy

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          Interactions
          PrevacidOmeprazole
          • Can interact with other drugs, so be sure your doctor knows all the medicine you're taking before starting Prevacid (Lansoprazole).
          • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Prevacid (Lansoprazole).
          • Can interact with other drugs so be sure your doctor knows all the medicine you're taking before starting Omeprazole.
          • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Omeprazole.
          Food
          PrevacidOmeprazole
          • Take Prevacid (Lansoprazole) about 1 hour before a meal.
          • Take 1 hour before a meal.
          Upsides and benefits
          PrevacidOmeprazole
          • Most people can take Prevacid (Lansoprazole) without any noticeable day-to-day side effects.
          • Prevacid (Lansoprazole) lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
          • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
          • Available as both a generic and over-the-counter option, so it's pretty affordable.
          • Sometimes if one PPI doesn't work, another medication in the same class will work for you.
          • Most people can take Omeprazole without any noticeable day-to-day side effects.
          • Omeprazole lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
          • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
          • In studies it was better than a placebo (sugar pill) and as good as other proton pump inhibitors at treating heartburn.
          • Available as both a generic and over-the-counter option, so it's pretty affordable.
          Downsides and risks
          PrevacidOmeprazole
          • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
          • Depending on the condition you are treating, it can take one to two weeks to get the full effect.
          • If you are taking Prevacid (Lansoprazole) for a long time you should take a calcium supplement to prevent fragile bones.
          • Can interact with other drugs, so be sure your doctor knows all the medicine you're taking before starting Prevacid (Lansoprazole).
          • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
          • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
          • Can cause low levels of magnesium in the blood. You might need to take a magnesium supplement if you use Omeprazole long-term.
          • Although the generic is affordable, other medications might still be cheaper than Omeprazole.
          • Can interact with other drugs so be sure your doctor knows all the medicine you're taking before starting Omeprazole.
          Tips from our pharmacists for people taking the medication
          PrevacidOmeprazole
          • Take Prevacid (Lansoprazole) about 1 hour before a meal.
          • Don't chew or crush capsules, but swallow them whole.
          • If you have trouble swallowing, there's a tablet available that dissolves in your mouth.
          • Give Prevacid (Lansoprazole) a chance to work. You'll see some benefits right away, but the full effects can take a week or so to kick in.
          • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Prevacid (Lansoprazole).
          • Take 1 hour before a meal.
          • Don't chew or crush capsules; swallow them whole.
          • If you have trouble swallowing you can carefully open the capsules and sprinkle the inside pellets onto applesauce. Swallow the applesauce without chewing or crushing the pellets.
          • When using Omeprazole long-term, take a calcium citrate with vitamin D supplement daily to prevent bone loss. Be sure it's calcium citrate because it works the best when using a proton pump inhibitor.
          • Get a blood test for your magnesium level once a year; you may need a magnesium supplement while using Omeprazole.
          • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Omeprazole.
          Learn more
          More about PrevacidSide effectsReviews & ratingsAlternativesFDA package insert
          Have you used Prevacid (lansoprazole)?
          Worth itNot sureNot worth it
          More about OmeprazoleSide effectsReviews & ratingsAlternativesFDA package insert
          Have you used Prilosec (omeprazole)?
          Worth itNot sureNot worth it