Compare Prevacid vs. Pepcid

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Prevacid
(lansoprazole)

Pepcid
(Famotidine)

Treats heartburn and stomach ulcers. Prevacid (lansoprazole) is an effective and inexpensive acid reducer commonly used to provide heartburn relief and help heal ulcers.Relieves heartburn. Pepcid (Famotidine) works well for heartburn but may not last as long or start working as quickly as other antacids.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.48Prevacid
Reviews for Prevacid
71%
of people (All ages) say Prevacid is worth it
71%
say it works well
19%
say it's a big hassle
Have you used Prevacid (lansoprazole)?
Worth itNot sureNot worth it
Reviews for Pepcid
75%
-4% worse vs. Prevacid
41%
+30% better vs. Prevacid
8%
-11% worse vs. Prevacid
853 reviews
Have you used Pepcid (Famotidine)?
Worth itNot sureNot worth it
Side effects
PrevacidPepcid
  • Abdominal pain 1%
  • Diarrhea 2%
More Prevacid side effects »
  • Diarrhea 2%
  • Headache 5%
More Pepcid side effects »
How it works
PrevacidPepcid
Prevacid (lansoprazole) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach by blocking the final step of stomach acid production.Pepcid (Famotidine) is a type of antacid called an H2 blocker. It blocks the chemical histamine, which lowers acid production in your stomach. This treats heartburn and helps ulcers heal.
Type of medication
PrevacidPepcid
Prescription or OTCLower-cost generic availablePrescription or OTCLower-cost generic available
Available as
PrevacidPepcid
  • Extended release
  • Dissolving tablet extended release
  • Liquid
  • Pill
  • Chewable tablet
  • Liquid
Used for
PrevacidPepcid
Risk factors for serious side effects
PrevacidPepcid
  • High dose Prevacid (lansoprazole)
  • Long-term treatment with Prevacid (lansoprazole)
  • Low bone mineral density
  • Older age
Detailed Prevacid (lansoprazole) risks & warnings »
  • Current kidney disease
Detailed Pepcid (Famotidine) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Price
PrevacidPepcid
  • Prevacid (lansoprazole) is available over-the-counter and as inexpensive, generic options.
No price related info.
Interactions
PrevacidPepcid
  • Some prescription drugs can interact with Prevacid (lansoprazole), so talk to your doctor or pharmacist about the medicines you are taking.
  • Few drug interactions.
Kidneys and liver
PrevacidPepcid
  • Prevacid (lansoprazole) can cause acute kidney damage that can occur at any time during treatment. Stop taking Prevacid (lansoprazole) and speak to your doctor immediately if you notice blood in the urine, changes in urine output, swelling of the body, weight gain, fever, or confusion.
  • Because Pepcid (Famotidine) is processed by the kidney it can cause some worrisome side effects for people with kidney problems. These include confusion, delirium, and a dangerous irregular heartbeat known as QT prolongation. If you have kidney problems, you may need a different dose to prevent this increased risk for side effects.
  • Can cause more serious side effects for people with kidney disease. Ask your doctor to give you a lower dose or choose a different option.
Upsides and benefits
PrevacidPepcid
  • Most people can take Prevacid (lansoprazole) without any noticeable day-to-day side effects.
  • Comes in a dissolving tablet to be placed on the tongue if you cannot or do not like to swallow pills.
  • Prevacid (lansoprazole) lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once a day.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • Prevacid (lansoprazole) is available over-the-counter and as inexpensive, generic options.
  • Most people can take Famotidine without any noticeable day-to-day side effects.
  • Famotidine lasts longer than many other antacids like Maalox and Tums, and you only need to take it once or twice a day.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • Available as both a generic and over-the-counter option, so it's pretty affordable.
  • Few drug interactions.
Downsides and risks
PrevacidPepcid
  • Doesn't start working right away like some other acid reducers (Tums, Rolaids, or Maalox).
  • May not be the best choice for patients 65 years of age and older due to risk of bone fractures and C. diff infection (bacterial).
  • Is used if you have frequent heartburns that occur more than 2 days per week. Speak to your doctor or pharmacist if you only have occasional heartburn.
  • Other antacids like Maalox, Tums, or Rolaids often start to work more quickly than Famotidine.
  • Medication like omeprazole (proton pump inhibitors) works better at healing and preventing stomach ulcers than medication like Famotidine (H2 blockers).
  • Can cause more serious side effects for people with kidney disease. Ask your doctor to give you a lower dose or choose a different option.
Tips from our pharmacists for people taking the medication
PrevacidPepcid
  • Take Prevacid (lansoprazole) with a full glass of water before eating.
  • Starts working in 1 to 3 hours. It can take 1 to 4 days to take full effect.
  • Some prescription drugs can interact with Prevacid (lansoprazole), so talk to your doctor or pharmacist about the medicines you are taking.
  • Do not take for more than 14 days, unless directed by your doctor. Speak to your doctor if your symptoms don't go away after 2 weeks.
  • Prevacid (lansoprazole) capsules can be opened and sprinkled on 1 tablespoon of applesauce, cottage cheese, or yogurt. Swallow immediately after. The dissolving tablets shouldn't be swallowed, broken, or chewed.
  • Short-term treatment of ulcers and acid reflux.
Learn more
More about PrevacidSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Prevacid (lansoprazole)?
Worth itNot sureNot worth it
More about PepcidSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Pepcid (Famotidine)?
Worth itNot sureNot worth it