Compare Prevacid vs. Pepcid

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Prevacid
(lansoprazole)

Pepcid
(famotidine)

Treats heartburn and stomach ulcers. Prevacid (Lansoprazole) gives you long-lasting heartburn relief and helps heal ulcers.Relieves heartburn. Pepcid (Famotidine) works well for heartburn but may not last as long or start working as quickly as other antacids.
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Coupons for Prevacid
Best available price for 30 (30mg) capsules of lansoprazole
Coupons for Pepcid
Best available price for 60 (20mg) tablets of famotidine
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.48Prevacid
Reviews for Prevacid (lansoprazole)
71%
of people (All ages) say Prevacid (lansoprazole) is worth it
71%
say it works well
19%
say it's a big hassle
Have you used Prevacid (lansoprazole)?
Worth itNot sureNot worth it
Reviews for Pepcid (famotidine)
75%
+4% better vs. Prevacid (lansoprazole)
41%
-30% worse vs. Prevacid (lansoprazole)
8%
+11% better vs. Prevacid (lansoprazole)
853 reviews
Have you used Pepcid (famotidine)?
Worth itNot sureNot worth it
Side effects
PrevacidPepcid
  • Diarrhea 2%
  • Abdominal pain 1%
More Prevacid side effects »
  • Headache 5%
  • Diarrhea 2%
More Pepcid side effects »
How it works
PrevacidPepcid
Prevacid (Lansoprazole) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach, treats heartburn, and heals ulcers.Pepcid (Famotidine) is a type of antacid called an H2 blocker. It blocks the chemical histamine, which lowers acid production in your stomach. This treats heartburn and helps ulcers heal.
Type of medication
PrevacidPepcid
Prescription or OTC
Prescription or OTC
Available as
PrevacidPepcid
  • Extended release
  • Dissolving tablet extended release
  • Pill
  • Chewable tablet
  • Liquid
Used for
PrevacidPepcid
Risk factors for serious side effects
PrevacidPepcid
  • Helicobacter pylori infection
  • Autoimmune disease
  • Being hospitalized
  • Antibiotic use
  • Osteoporosis
Detailed Prevacid (lansoprazole) risks & warnings »
  • Current kidney disease
Detailed Pepcid (famotidine) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Interactions
PrevacidPepcid
  • Can interact with other drugs, so be sure your doctor knows all the medicine you're taking before starting Prevacid (Lansoprazole).
  • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Prevacid (Lansoprazole).
  • Few drug interactions.
Food
PrevacidPepcid
  • Take Prevacid (Lansoprazole) about 1 hour before a meal.
No food related info.
Kidneys and liver
PrevacidPepcid
No kidneys and liver related info.
  • Can cause more serious side effects for people with kidney disease. Ask your doctor to give you a lower dose or choose a different option.
  • Because Pepcid (Famotidine) is processed by the kidney it can cause some worrisome side effects for people with kidney problems. These include confusion, delirium, and a dangerous irregular heartbeat known as QT prolongation. If you have kidney problems, you may need a different dose to prevent this increased risk for side effects.
Upsides and benefits
PrevacidPepcid
  • Most people can take Prevacid (Lansoprazole) without any noticeable day-to-day side effects.
  • Prevacid (Lansoprazole) lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • Available as both a generic and over-the-counter option, so it's pretty affordable.
  • Sometimes if one PPI doesn't work, another medication in the same class will work for you.
  • Most people can take Famotidine without any noticeable day-to-day side effects.
  • Famotidine lasts longer than many other antacids like Maalox and Tums, and you only need to take it once or twice a day.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • Available as both a generic and over-the-counter option, so it's pretty affordable.
  • Few drug interactions.
Downsides and risks
PrevacidPepcid
  • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
  • Depending on the condition you are treating, it can take one to two weeks to get the full effect.
  • If you are taking Prevacid (Lansoprazole) for a long time you should take a calcium supplement to prevent fragile bones.
  • Can interact with other drugs, so be sure your doctor knows all the medicine you're taking before starting Prevacid (Lansoprazole).
  • Other antacids like Maalox, Tums, or Rolaids often start to work more quickly than Famotidine.
  • Medication like omeprazole (proton pump inhibitors) works better at healing and preventing stomach ulcers than medication like Famotidine (H2 blockers).
  • Can cause more serious side effects for people with kidney disease. Ask your doctor to give you a lower dose or choose a different option.
Tips from our pharmacists for people taking the medication
PrevacidPepcid
  • Take Prevacid (Lansoprazole) about 1 hour before a meal.
  • Don't chew or crush capsules, but swallow them whole.
  • If you have trouble swallowing, there's a tablet available that dissolves in your mouth.
  • Give Prevacid (Lansoprazole) a chance to work. You'll see some benefits right away, but the full effects can take a week or so to kick in.
  • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Prevacid (Lansoprazole).
  • Short-term treatment of ulcers and acid reflux.
Learn more
More about PrevacidSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Prevacid (lansoprazole)?
Worth itNot sureNot worth it
More about PepcidSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Pepcid (famotidine)?
Worth itNot sureNot worth it