Compare Prevacid vs. Tagamet

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Prevacid
(Lansoprazole)

Tagamet
(Cimetidine)

Treats heartburn and stomach ulcers. Prevacid (Lansoprazole) gives you long-lasting heartburn relief and helps heal ulcers.Relieves heartburn and acid tummy. Tagamet (Cimetidine) works well for heartburn but may not last as long or start working as quickly as other antacids.
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Reviews & ratings
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Reviews for Tagamet (Cimetidine)
63%
4% vs. Prevacid (Lansoprazole)
36%
31% vs. Prevacid (Lansoprazole)
12%
4% vs. Prevacid (Lansoprazole)
Side effects
PrevacidTagamet
  • Diarrhea 2%
  • Abdominal pain 1%
More Prevacid side effects »
  • Headache 2%
More Tagamet side effects »
How it works
PrevacidTagamet
Prevacid (Lansoprazole) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach, treats heartburn, and heals ulcers.Tagamet (Cimetidine) is a type of antacid called an H2 blocker. It blocks the chemical histamine, which lowers acid production in your stomach. This treats heartburn and helps ulcers heal.
Type of medication
PrevacidTagamet
Acid reducer
Proton pump inhibitor
Prescription or OTC
Acid reducer
Histamine blocker
Prescription or OTC
Available as
PrevacidTagamet
  • Extended release
  • Dissolving tablet extended release
  • Pill
  • Liquid
Used for (click to learn more)
PrevacidTagamet
Risk factors for serious side effects
PrevacidTagamet
    • Helicobacter pylori infection
    • Autoimmune disease
    • Being hospitalized
    • Antibiotic use
    • Osteoporosis
    • Age 50 or older
    • Using high medication doses
    • Long-term therapy (1 year or more)
    • Smoking
    • Use of other medications that weaken bones
      Detailed Prevacid (Lansoprazole) risks & warnings »
        • Current kidney disease
        • Current liver disease
        • Age 50 or older
        • Current severe illness
          • Autoimmune disease
          • HIV or AIDS
          • Organ transplant
          • People without a spleen
          Detailed Tagamet (Cimetidine) risks & warnings »
          Pregnancy category
          PrevacidTagamet
          BFDA pregnancy category (Probably safe)

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          See the FDA package insert
          BFDA pregnancy category (Probably safe)

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          See the FDA package insert
          Alcohol
          No specific alcohol-related info.No specific alcohol-related info.
          Food
          • Take Prevacid (Lansoprazole) about 1 hour before a meal.
          No specific food-related info.
          Kidneys and liver
          No specific kidneys and liver-related info.
          • People with kidney disease may need to take a lower dose.
          • Tagamet (Cimetidine) can cause states of intense confusion. This is usually reversible when you stop taking Tagamet (Cimetidine). If you have kidney problems, you may need a different dose to prevent this increased risk for side effects. However, stopping Tagamet (Cimetidine) completely may be necessary.
          Sex
          No specific sex-related info.No specific sex-related info.
          Sleep
          No specific sleep-related info.No specific sleep-related info.
          Weight
          No specific weight-related info.No specific weight-related info.
          Upsides and benefits
          PrevacidTagamet
          • Most people can take Prevacid (Lansoprazole) without any noticeable day-to-day side effects.
          • Prevacid (Lansoprazole) lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
          • Sometimes if one PPI doesn't work, another medication in the same class will work for you.
          • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
          • Available as both a generic and over-the-counter option, so it's pretty affordable.
          • Most people can take Cimetidine without any noticeable day-to-day side effects.
          • Cimetidine lasts longer than many other antacids like Maalox and Tums, and you only need to take it once or twice a day.
          • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
          • Available as both a generic and over-the-counter option, so it's pretty affordable.
          Downsides and risks
          PrevacidTagamet
          • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
          • Depending on the condition you are treating, it can take one to two weeks to get the full effect.
          • If you are taking Prevacid (Lansoprazole) for a long time you should take a calcium supplement to prevent fragile bones.
          • Can interact with other drugs, so be sure your doctor knows all the medicine you're taking before starting Prevacid (Lansoprazole).
          • Other antacids like Maalox, Tums, or Rolaids often start to work more quickly than Cimetidine.
          • Medication like omeprazole (proton pump inhibitors) works better at healing and preventing stomach ulcers than medication like Cimetidine (H2 blockers).
          • Has more drug interactions than zantac and pepcid.
          • Although rare, Cimetidine can cause large breasts or impotence for men who need to use high doses for 6 months or more. It's reversible though and should go away when you stop or if you change medication.
          Tips from our pharmacists for people taking the medication
          PrevacidTagamet
          • Take Prevacid (Lansoprazole) about 1 hour before a meal.
          • Don't chew or crush capsules, but swallow them whole.
          • If you have trouble swallowing, there's a tablet available that dissolves in your mouth.
          • Give Prevacid (Lansoprazole) a chance to work. You'll see some benefits right away, but the full effects can take a week or so to kick in.
          • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Prevacid (Lansoprazole).
          • Works best if you take it with a full glass of water.
          • Starts working in one hour.
          • If heartburn doesn't improve or lasts more than 2 weeks, talk to your doctor.
          • People with kidney disease may need to take a lower dose.
          • Tell your doctor all of the medications that you use before taking Cimetidine to avoid drug interactions.
          Learn more
          More about PrevacidSide effectsReviews & ratingsAlternativesFDA package insert
          More about TagametSide effectsReviews & ratingsAlternativesFDA package insert