Compare Prevacid vs. Zantac

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Prevacid
(Lansoprazole)

Zantac 75
(Ranitidine)

Treats heartburn and stomach ulcers. Prevacid (Lansoprazole) gives you long-lasting heartburn relief and helps heal ulcers.Relieves heartburn. Zantac 75 (Ranitidine) works well for heartburn but may not last as long or start working as quickly as other antacids.
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Reviews & ratings
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Reviews for Zantac 75 (Ranitidine)
72%
+5% vs. Prevacid (Lansoprazole)
43%
24% vs. Prevacid (Lansoprazole)
7%
+1% vs. Prevacid (Lansoprazole)
Side effects
PrevacidZantac
  • Diarrhea 2%
  • Abdominal pain 1%
More Prevacid side effects »

The Zantac FDA package insert doesn’t have numbers about how common side effects are.

More about Zantac side effects »
How it works
PrevacidZantac
Prevacid (Lansoprazole) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach, treats heartburn, and heals ulcers.Zantac 75 (Ranitidine) is an H2 blocker. It blocks the chemical histamine, which lowers acid production in your stomach. This treats heartburn and helps ulcers heal.
Type of medication
PrevacidZantac
Acid reducer
Proton pump inhibitor
Prescription or OTC
Acid reducer
Histamine blocker
Prescription or OTC
Available as
PrevacidZantac
  • Extended release
  • Dissolving tablet extended release
  • Pill
  • Oral solution
  • Injection
Used for (click to learn more)
PrevacidZantac
Risk factors for serious side effects
PrevacidZantac
    • Helicobacter pylori infection
    • Autoimmune disease
    • Being hospitalized
    • Antibiotic use
    • Osteoporosis
    • Age 50 or older
    • Using high medication doses
    • Long-term therapy (1 year or more)
    • Smoking
    • Use of other medications that weaken bones
      Detailed Prevacid (Lansoprazole) risks & warnings »
        • Current kidney problems
        • Current liver problems
        • Acute Porphyria
        • History of Phenylketonuria (PKU)
        Detailed Zantac 75 (Ranitidine) risks & warnings »
        Pregnancy category
        PrevacidZantac
        BFDA pregnancy category (Probably safe)

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        See the FDA package insert
        BFDA pregnancy category (Probably safe)

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        See the FDA package insert
        Alcohol
        No specific alcohol-related info.No specific alcohol-related info.
        Food
        • Take Prevacid (Lansoprazole) about 1 hour before a meal.
        No specific food-related info.
        Kidneys and liver
        No specific kidneys and liver-related info.
        • People with kidney disease may need to take a lower dose.
        • Zantac 75 (Ranitidine) is processed by the kidney and liver. If you have kidney or liver problems, you may need a different dose to prevent this increased risk for side effects.
        Sex
        No specific sex-related info.No specific sex-related info.
        Sleep
        No specific sleep-related info.No specific sleep-related info.
        Weight
        No specific weight-related info.No specific weight-related info.
        Upsides and benefits
        PrevacidZantac
        • Most people can take Prevacid (Lansoprazole) without any noticeable day-to-day side effects.
        • Prevacid (Lansoprazole) lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
        • Sometimes if one PPI doesn't work, another medication in the same class will work for you.
        • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
        • Available as both a generic and over-the-counter option, so it's pretty affordable.
        • Most people can take Ranitidine without any noticeable day-to-day side effects.
        • Ranitidine lasts longer than many other antacids like Maalox and Tums, and you only need to take it once or twice a day.
        • Few drug interactions.
        • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
        • Available as both a generic and over-the-counter option, so it's pretty affordable.
        Downsides and risks
        PrevacidZantac
        • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
        • Depending on the condition you are treating, it can take one to two weeks to get the full effect.
        • If you are taking Prevacid (Lansoprazole) for a long time you should take a calcium supplement to prevent fragile bones.
        • Can interact with other drugs, so be sure your doctor knows all the medicine you're taking before starting Prevacid (Lansoprazole).
        • Other antacids like Maalox, Tums, or Rolaids often start to work more quickly than Ranitidine.
        • Medication like omeprazole (proton pump inhibitors) works better at healing and preventing stomach ulcers than medication like Ranitidine (H2 blockers).
        Tips from our pharmacists for people taking the medication
        PrevacidZantac
        • Take Prevacid (Lansoprazole) about 1 hour before a meal.
        • Don't chew or crush capsules, but swallow them whole.
        • If you have trouble swallowing, there's a tablet available that dissolves in your mouth.
        • Give Prevacid (Lansoprazole) a chance to work. You'll see some benefits right away, but the full effects can take a week or so to kick in.
        • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Prevacid (Lansoprazole).
        • Works best if you take it with a full glass of water.
        • Starts working in one hour.
        • If heartburn doesn't improve or lasts more than 2 weeks, talk to your doctor.
        • People with kidney disease may need to take a lower dose.
        Learn more
        More about PrevacidSide effectsReviews & ratingsAlternativesFDA package insert
        More about ZantacSide effectsReviews & ratingsAlternativesFDA package insert