Compare Prevacid vs. Zantac

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Prevacid (lansoprazole)

Prescription or OTC

Zantac 75 (ranitidine)

Prescription or OTC
Treats heartburn and stomach ulcers.

Prevacid (lansoprazole) is an effective and inexpensive acid reducer commonly used to provide heartburn relief and help heal ulcers.

5.5/ 7 average rating with 21 reviewsforPrevacid
Relieves heartburn and stomach ulcers.

Zantac 75 (ranitidine) is an effective and inexpensive medicine for hearburn with few side effects, but may interfere with other drugs.

5.1/ 7 average rating with 1062 reviewsforZantac
Upsides
  • Most people can take Prevacid (lansoprazole) without any noticeable day-to-day side effects.
  • Comes in a dissolving tablet to be placed on the tongue if you cannot or do not like to swallow pills.
  • Prevacid (lansoprazole) lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once a day.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • Prevacid (lansoprazole) is available over-the-counter and as inexpensive, generic options.
  • Zantac 75 (ranitidine) works well to relieve heartburn symtoms and is quite tolerable.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • If you have trouble swallowing pills you may find the liquid product a good option.
  • Inexpensive with over-the-counter and generic options.
  • Coupons are available for the brand product - speak to your doctor or pharmacist.
Downsides
  • Doesn't start working right away like some other acid reducers (Tums, Rolaids, or Maalox).
  • May not be the best choice for patients 65 years of age and older due to risk of bone fractures and C. diff infection (bacterial).
  • Is used if you have frequent heartburns that occur more than 2 days per week. Speak to your doctor or pharmacist if you only have occasional heartburn.
  • Zantac 75 (ranitidine) doesn't work as quickly as some other acid reducers. Speak to your doctor or pharmacist if you need quicker relief.
  • Zantac 75 (ranitidine) does not last as long as some other acid reducers. Speak to your doctor or pharmacist if you need longer relief.
  • May not be as effective in healing the esophagus when it is inflammed or torn, known as erosive esophagitis. Your doctor will assess which medication is best for you.
  • Can lower your vitamin B12 levels if you use Zantac 75 (ranitidine) for a long time. Your doctor can order lab tests to monitor your vitamin B12 levels.
Used for
Dosage forms
  • Extended release
  • Dissolving tablet extended release
  • Liquid
  • Pill
  • Oral solution
  • Oral syrup
  • Injection
Price
Lowest price near you
$17.45
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Reviews
21 
71%
think this treatment is worth it
71%
think this treatment works well
19%
think this treatment is a hassle

Have you used Prevacid (lansoprazole)?

Leave a review
1062 
72%
think this treatment is worth it
44%
think this treatment works well
7%
think this treatment is a hassle

Have you used Zantac 75 (ranitidine)?

Leave a review
Side effects
2possible side effects
  • Diarrhea
    4%
  • Abdominal pain
    2%
See more detailed side effects
The Zantac 75 (ranitidine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Bone fractures

    High dose Prevacid (lansoprazole)

    ...and 3 more risk factors

See more detailed risks and warnings
  • Confusion

    Aged 60 years or older

    ...and 2 more risk factors

  • Acute porphyria

    Acute Porphyria

  • Chronic lung problems

    Asthma

    ...and 2 more risk factors

See more detailed risks and warnings