Compare Prevacid vs. Zantac

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Prevacid
(lansoprazole)

Zantac 75
(ranitidine)

Treats heartburn and stomach ulcers. Prevacid (lansoprazole) is an effective and inexpensive acid reducer commonly used to provide heartburn relief and help heal ulcers.Relieves heartburn and stomach ulcers. Zantac 75 (ranitidine) is an effective and inexpensive medicine for hearburn with few side effects, but may interfere with other drugs.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.48Prevacid
Reviews for Prevacid
71%
of people (All ages) say Prevacid is worth it
71%
say it works well
19%
say it's a big hassle
Have you used Prevacid (lansoprazole)?
Worth itNot sureNot worth it
Reviews for Zantac
72%
-1% worse vs. Prevacid
44%
+27% better vs. Prevacid
7%
-12% worse vs. Prevacid
1062 reviews
Have you used Zantac 75 (ranitidine)?
Worth itNot sureNot worth it
Side effects
PrevacidZantac
  • Diarrhea 2%
  • Abdominal pain 1%
More Prevacid side effects »

The Zantac FDA package insert doesn’t have numbers about how common side effects are.

More about Zantac side effects »
How it works
PrevacidZantac
Prevacid (lansoprazole) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach by blocking the final step of stomach acid production.Zantac 75 (ranitidine) reduces the production of acid by blocking a chemical from acting on the acid-producing cells in your stomach.
Type of medication
PrevacidZantac
Prescription or OTCPrescription or OTC
Available as
PrevacidZantac
  • Extended release
  • Dissolving tablet extended release
  • Liquid
  • Pill
  • Oral solution
  • Oral syrup
  • Injection
Used for
PrevacidZantac
Risk factors for serious side effects
PrevacidZantac
  • High dose Prevacid (lansoprazole)
  • Long-term treatment with Prevacid (lansoprazole)
  • Low bone mineral density
  • Older age
Detailed Prevacid (lansoprazole) risks & warnings »
  • Aged 60 years or older
  • Kidney conditions
  • Liver conditions
  • Acute Porphyria
  • Asthma
Detailed Zantac 75 (ranitidine) risks & warnings »
Pregnancy
Price
PrevacidZantac
  • Prevacid (lansoprazole) is available over-the-counter and as inexpensive, generic options.
No price related info.
Interactions
PrevacidZantac
  • Some prescription drugs can interact with Prevacid (lansoprazole), so talk to your doctor or pharmacist about the medicines you are taking.
  • Zantac 75 (ranitidine) can interact with certain prescription and over-the-counter medications. Let your doctor or pharmacist know about the medicines you are currently taking.
Alcohol
PrevacidZantac
No alcohol related info.
  • The syrup product may contain up to 7.5% of alcohol.
Kidneys and liver
PrevacidZantac
  • Prevacid (lansoprazole) can cause acute kidney damage that can occur at any time during treatment. Stop taking Prevacid (lansoprazole) and speak to your doctor immediately if you notice blood in the urine, changes in urine output, swelling of the body, weight gain, fever, or confusion.
No kidneys and liver related info.
Upsides and benefits
PrevacidZantac
  • Most people can take Prevacid (lansoprazole) without any noticeable day-to-day side effects.
  • Comes in a dissolving tablet to be placed on the tongue if you cannot or do not like to swallow pills.
  • Prevacid (lansoprazole) lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once a day.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • Prevacid (lansoprazole) is available over-the-counter and as inexpensive, generic options.
  • Zantac 75 (ranitidine) works well to relieve heartburn symtoms and is quite tolerable.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • If you have trouble swallowing pills you may find the liquid product a good option.
  • Inexpensive with over-the-counter and generic options.
  • Coupons are available for the brand product - speak to your doctor or pharmacist.
Downsides and risks
PrevacidZantac
  • Doesn't start working right away like some other acid reducers (Tums, Rolaids, or Maalox).
  • May not be the best choice for patients 65 years of age and older due to risk of bone fractures and C. diff infection (bacterial).
  • Is used if you have frequent heartburns that occur more than 2 days per week. Speak to your doctor or pharmacist if you only have occasional heartburn.
  • Zantac 75 (ranitidine) doesn't work as quickly as some other acid reducers. Speak to your doctor or pharmacist if you need quicker relief.
  • Zantac 75 (ranitidine) does not last as long as some other acid reducers. Speak to your doctor or pharmacist if you need longer relief.
  • May not be as effective in healing the esophagus when it is inflammed or torn, known as erosive esophagitis. Your doctor will assess which medication is best for you.
  • Can lower your vitamin B12 levels if you use Zantac 75 (ranitidine) for a long time. Your doctor can order lab tests to monitor your vitamin B12 levels.
Tips from our pharmacists for people taking the medication
PrevacidZantac
  • Take Prevacid (lansoprazole) with a full glass of water before eating.
  • Starts working in 1 to 3 hours. It can take 1 to 4 days to take full effect.
  • Some prescription drugs can interact with Prevacid (lansoprazole), so talk to your doctor or pharmacist about the medicines you are taking.
  • Do not take for more than 14 days, unless directed by your doctor. Speak to your doctor if your symptoms don't go away after 2 weeks.
  • Prevacid (lansoprazole) capsules can be opened and sprinkled on 1 tablespoon of applesauce, cottage cheese, or yogurt. Swallow immediately after. The dissolving tablets shouldn't be swallowed, broken, or chewed.
  • To prevent a heartburn attack, take Zantac 75 (ranitidine) 30 minutes before eating.
  • Works within 30 to 60 minutes. Relief lasts up to 12 hours.
  • Do not use Zantac 75 (ranitidine) for more than 14 days. Talk to your doctor if your symptoms do not improve after 2 weeks of using the over-the-counter product, as this may indicate a more serious problem.
  • The syrup product may contain up to 7.5% of alcohol.
  • Speak to your doctor or pharmacist about lifestyle and dietary changes that can help prevent heartburn.
Learn more
More about PrevacidSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Prevacid (lansoprazole)?
Worth itNot sureNot worth it
More about ZantacSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zantac 75 (ranitidine)?
Worth itNot sureNot worth it