Compare Prezista vs. Isentress

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Prezista (darunavir)

Isentress (raltegravir)

Prescription only
Treats HIV infection.

Prezista (darunavir) is one of the first-choices for treatment of HIV because it has fewer side-effects compared to other medicines that work like it.

Works with other medicications to treat HIV infection.

Isentress (raltegravir) is considered a first choice to be used with other medications for treating HIV, but it can have more side effects than other similar medicines.

Upsides
  • Prezista (darunavir) is a good choice for those newly diagnosed HIV.
  • May be used in combination with other HIV medicines if you have been accidentally exposed to HIV by a needle-stick.
  • Available as a liquid solution and can be used for children as young as 3 years old.
  • Isentress (raltegravir) is a first choice treatment to use together with other medications to treat HIV.
  • If you have difficulty swallowing the tablet, there is a chewable tablet or oral suspension available.
  • Can be used by children 4 weeks and older.
  • People with mild to moderate kidney or liver damage can use Isentress (raltegravir).
Downsides
  • Need to take together with a booster like Norvir.
  • Doesn't work as well for those with longstanding HIV.
  • Can affect your cholestorol and blood sugar levels.
  • It might be hard to remember to take Isentress (raltegravir) two times a day. Other similar medicines are once a day.
  • The chewable tablets contain phenylalanine and should be avoided in people who have phenylketonuria.
  • Isentress (raltegravir) cannot be used alone to treat or prevent HIV. It must be used together with other medications.
  • Not available as part of a combination tablet, so you'll have to take more tablets daily compared to other combinations.
Used for
Dosage forms
  • Pill
  • Liquid
  • Pill
  • Chewable tablet
  • Liquid
Price
Lowest price near you
$1501.09
Find instant savings
Lowest price near you
$1424.38
Find instant savings
Want to save even more money?
Sign up now for a 30-day trial and save up to 95% at Kroger, Albertsons, Safeway, and other pharmacies.
Reviews
Not enough review data.Leave a review
Not enough review data.Leave a review
Side effects
7possible side effects
  • Diarrhea
    14%
  • Headache
    7%
  • Nausea
    7%
  • Rash
    7%
  • Abdominal pain
    6%
  • Vomiting
    5%
  • Physical weakness
    3%
See more detailed side effects
5possible side effects
  • Headache
    4%
  • Insomnia
    4%
  • Nausea
    3%
  • Fatigue
    2%
  • Dizziness
    2%
See more detailed side effects
Risks and warnings
  • Liver damage

    History of liver damage

    ...and 1 more risk factors

  • Fat redistribution

    HIV treatment

  • Immune recovery syndrome

    HIV

    ...and 3 more risk factors

  • Diabetes

    Use of protease inhibitors

    ...and 1 more risk factors

See more detailed risks and warnings
  • Severe skin reactions

    Prior severe allergic reaction to Isentress

  • Allergic reactions

    Prior severe allergic reaction to Isentress

  • Rhabdomyolysis (Muscle damage)

    Concurrent use of other drugs which can cause muscle pain/damage

  • Immune reconstitution syndrome

    HIV

    ...and 3 more risk factors

See more detailed risks and warnings