Compare Pristiq vs. Oleptro

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Pristiq
(desvenlafaxine)

Oleptro
(trazodone)

Improves mood. Pristiq (Desvenlafaxine) is basically the same medication as Effexor, which is cheaper because it's available as a generic.Improves mood and helps you sleep. Oleptro (Trazodone) works well as a sleep aid, but has more side effects when used at higher doses for treating depression.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.81Pristiq
Reviews for Pristiq
53%
of people (All ages) say Pristiq is worth it
49%
say it works well
23%
say it's a big hassle
196 reviews
Have you used Pristiq (desvenlafaxine)?
Worth itNot sureNot worth it
Reviews for Oleptro
73%
-20% worse vs. Pristiq
49%
Same vs. Pristiq
24%
+1% better vs. Pristiq
Have you used Oleptro (trazodone)?
Worth itNot sureNot worth it
Side effects
PristiqOleptro
  • Nausea 16%
  • Dry mouth 8%
  • Insomnia 6%
  • Hyperhidrosis 7%
  • Dizziness 5%
  • Somnolence 5%
  • Constipation 5%
  • Decreased appetite 6%
  • Fatigue 3%
  • Anxiety 3%
More Pristiq side effects »
  • Somnolence/Sedation 27%
  • Drowsiness 21%
  • Dry Mouth 14%
  • Headache 6%
  • Dizziness/Lightheadedness 13%
  • Dry mouth 12%
  • Dizziness 13%
  • Nausea 8%
  • Fatigue 7%
More Oleptro side effects »
How it works
PristiqOleptro
Pristiq (Desvenlafaxine) is a serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant. It increases serotonin and norepinephrine activity in the brain, which regulates mood.Oleptro (Trazodone) is a serotonin reuptake inhibitor (SRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.
Type of medication
PristiqOleptro
Prescription onlyPrescription only
Available as
PristiqOleptro
  • Extended release
  • Pill
  • Extended release
Used for
PristiqOleptro
Risk factors for serious side effects
PristiqOleptro
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • Stopping Pristiq (Desvenlafaxine) suddenly
  • History of high blood pressure
  • Taking other blood-thinning drugs
Detailed Pristiq (desvenlafaxine) risks & warnings »
  • Age 24 years or younger
  • History of seizures
  • Alcoholism
  • Eating disorder
  • Higher dose
Detailed Oleptro (trazodone) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Upsides and benefits
PristiqOleptro
  • Effective at relieving symptoms and lowering relapse rates for depression.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
  • Commonly used in lower doses to help treat sleep problems (insomnia).
  • Safer sleep medication than others (benzodiazepines or Unisom) for people age 65 and older.
  • Fewer sexual side effects than many other antidepressants.
  • Has been used for sleep and depression for a long time. There's a lot of information available about how it works and how safe it is.
  • Comes as a generic medication and is cheaper than many other sleep aides.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
Downsides and risks
PristiqOleptro
  • Similar to Effexor, without any extra benefits in clinical studies.
  • Can cause sexual side effects (usually low libido or the inability to have an orgasm or ejaculate).
  • Not available in generic form, so it's more expensive.
  • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
  • Not as effective as other medications for depression.
  • More sedating than other antidepressants.
  • Causes more side effects when used at higher doses for depression. Includes sleepiness, dizziness, upset stomach, and irregular heartbeat.
  • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
Tips from our pharmacists for people taking the medication
PristiqOleptro
  • Takes 8 to 12 weeks to see full effects on mood.
  • Can cause sweating and high blood pressure.
  • Stop taking slowly to avoid withdrawal symptoms.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
  • Makes you sleepy. Take at bedtime.
  • Can cause temporary dry mouth and upset stomach.
  • Seek medical attention for unwanted, persistent erection.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
Learn more
More about PristiqSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Pristiq (desvenlafaxine)?
Worth itNot sureNot worth it
More about OleptroSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Oleptro (trazodone)?
Worth itNot sureNot worth it