Compare Pristiq vs. Remeron

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Pristiq (Desvenlafaxine)

Prescription only

Remeron (mirtazapine)

Prescription only
Improves mood.

Pristiq (Desvenlafaxine) is basically the same medication as Effexor, which is cheaper because it's available as a generic.

4.8/ 7 average rating with 196 reviewsforPristiq
Improves mood.

Remeron (mirtazapine) improves your mood and helps you sleep better, but can cause more weight gain than any other antidepressant.

4.5/ 7 average rating with 152 reviewsforRemeron
Upsides
  • Effective at relieving symptoms and lowering relapse rates for depression.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
  • Effective at relieving some depression symptoms.
  • Starts to work more quickly than most antidepressants.
  • Can help you fall asleep if you have trouble sleeping.
  • Can also help relieve anxiety.
  • Good option if you are underweight or frail, because it can help you gain weight.
  • Available as a generic.
Downsides
  • Similar to Effexor, without any extra benefits in clinical studies.
  • Can cause sexual side effects (usually low libido or the inability to have an orgasm or ejaculate).
  • Not available in generic form, so it's more expensive.
  • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
  • Makes you more tired than other antidepressants.
  • More likely to cause minor weight gain (1-5 pounds) and raise cholesterol than any other antidepressant.
Used for
Dosage forms
  • Extended release
  • Pill
  • Dissolving tablet
Price
Lowest price near you
$382.02
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Lowest price near you
$10
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Reviews
196 
53%
think this treatment is worth it
49%
think this treatment works well
23%
think this treatment is a hassle

Have you used Pristiq (Desvenlafaxine)?

Leave a review
152 
45%
think this treatment is worth it
39%
think this treatment works well
26%
think this treatment is a hassle

Have you used Remeron (mirtazapine)?

Leave a review
Side effects
10possible side effects
  • Nausea
    22%
  • Dizziness
    13%
  • Dry mouth
    11%
  • Hyperhidrosis
    10%
  • Constipation
    9%
  • Insomnia
    9%
  • Fatigue
    7%
  • Decreased appetite
    5%
  • Somnolence
    4%
  • Vomiting
    3%
See more detailed side effects
The Remeron (mirtazapine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Suicidal thoughts or behavior

    Age 24 years or younger

  • Serotonin syndrome

    Using other medications that affect serotonin

  • Withdrawal

    Stopping Pristiq (Desvenlafaxine) suddenly

  • High blood pressure

    History of high blood pressure

  • Increased bleeding

    Taking other blood-thinning drugs

  • Mania

    History of bipolar disorder

    ...and 1 more risk factors

See more detailed risks and warnings
  • Suicidal thoughts or behavior

    Age 24 years or younger

  • Serotonin syndrome

    Using other medications that affect serotonin

  • Heart problems

    History of heart problems

    ...and 2 more risk factors

  • Driving impairment

    Alcohol

    ...and 1 more risk factors

See more detailed risks and warnings