Compare Pristiq vs. Remeron

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Pristiq
(desvenlafaxine)

Remeron
(mirtazapine)

Improves mood. Pristiq (Desvenlafaxine) is basically the same medication as Effexor, which is cheaper because it's available as a generic.Improves mood. Remeron (Mirtazapine) is okay for treating depression and good for sleep. More likely to cause weight gain than any other antidepressant.
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Reviews & ratings
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4.81Pristiq
Reviews for Pristiq (desvenlafaxine)
53%
of people (All ages) say Pristiq (desvenlafaxine) is worth it
49%
say it works well
23%
say it's a big hassle
196 reviews
Have you used Pristiq (desvenlafaxine)?
Worth itNot sureNot worth it
Reviews for Remeron (mirtazapine)
45%
-8% worse vs. Pristiq (desvenlafaxine)
39%
-10% worse vs. Pristiq (desvenlafaxine)
26%
-3% worse vs. Pristiq (desvenlafaxine)
152 reviews
Have you used Remeron (mirtazapine)?
Worth itNot sureNot worth it
Side effects
PristiqRemeron
  • Nausea 16%
  • Dry mouth 8%
  • Sleep difficulty 6%
  • Excessive sweating 7%
  • Dizziness 5%
  • Drowsiness 5%
  • Constipation 5%
  • Decreased appetite 6%
  • Fatigue 3%
  • Anxiety 3%
More Pristiq side effects »
  • Drowsiness 36%
  • Dry mouth 10%
  • Increased appetite 15%
  • Constipation 6%
  • Weight gain 10%
  • Muscle weakness 3%
  • Dizziness 4%
  • Flu syndrome 2%
  • Abnormal dreams 3%
  • Thinking abnormal 2%
More Remeron side effects »
How it works
PristiqRemeron
Pristiq (Desvenlafaxine) is a serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant. It increases serotonin and norepinephrine activity in the brain, which regulates mood.Remeron (Mirtazapine) is an atypical antidepressant. It stimulates your body to make certain chemicals in the brain, such as serotonin and norepinephrine, which regulate mood.
Type of medication
PristiqRemeron
Prescription only
Prescription only
Available as
PristiqRemeron
  • Extended release
  • Pill
  • Dissolving tablet
Used for
PristiqRemeron
Risk factors for serious side effects
PristiqRemeron
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • Stopping Pristiq (Desvenlafaxine) suddenly
  • History of high blood pressure
  • Taking other blood-thinning drugs
    • History of bipolar disorder
    • At risk for bipolar disorder
    Detailed Pristiq (desvenlafaxine) risks & warnings »
    • Age 24 years or younger
    • Using other medications that affect serotonin
    • History of heart problems
    • History of liver problems
    • Higher dose
    • Alcohol
    • Taking other medicines that make you less alert
        Detailed Remeron (mirtazapine) risks & warnings »
        Pregnancy

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Weight
        PristiqRemeron
        No weight related info.
        • More likely to cause minor weight gain (1 to 5 pounds) and raise cholesterol than any other antidepressant.
        • Can increase appetite and weight.
        • Remeron (Mirtazapine) can increase appetite and cause you to gain weight.
        Upsides and benefits
        PristiqRemeron
        • Effective at relieving symptoms and lowering relapse rates for depression.
        • Six out of ten people who use an antidepressant for the first time find that it works for them.
        • Effective at relieving some depression symptoms.
        • Starts to work more quickly than most antidepressants.
        • Might be a good option for people who have insomnia with their depression, because it can make you very sleepy.
        • Good option for people who are underweight or frail, because it can help you gain weight.
        • Six out of ten people who use an antidepressant for the first time find that it works for them.
        Downsides and risks
        PristiqRemeron
        • Similar to Effexor, without any extra benefits in clinical studies.
        • Can cause sexual side effects (usually low libido or the inability to have an orgasm or ejaculate).
        • Not available in generic form, so it's more expensive.
        • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
        • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
        • Not as effective as other medications for depression.
        • More sedating than other antidepressants.
        • More likely to cause minor weight gain (1 to 5 pounds) and raise cholesterol than any other antidepressant.
        • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
        • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
        Tips from our pharmacists for people taking the medication
        PristiqRemeron
        • Takes 8 to 12 weeks to see full effects on mood.
        • Can cause sweating and high blood pressure.
        • Stop taking slowly to avoid withdrawal symptoms.
        • Tell your doctor if you notice sudden mood changes or unusual thoughts.
        • Makes you sleepy. Take at bedtime.
        • Can increase appetite and weight.
        • Takes 8 to 12 weeks to see full effects on mood.
        • Stop taking slowly to avoid withdrawal symptoms.
        • Tell your doctor if you notice sudden mood changes or unusual thoughts.
        Learn more
        More about PristiqSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Pristiq (desvenlafaxine)?
        Worth itNot sureNot worth it
        More about RemeronSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Remeron (mirtazapine)?
        Worth itNot sureNot worth it