Compare Prograf vs. Afinitor

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Prograf (tacrolimus)

Prescription only
Prevents rejection of a transplanted organ.

Prograf (tacrolimus) is a good medicine that prevents rejection of an organ transplant, but you will need to be on it lifelong.

No information currently available
  • Prevents your body from rejecting a transplanted organ.
  • Available as an extended-release pill, so it can be taken just once daily.
  • Less cosmetic side-effects than other anti-rejection medicine like cyclosporine.
No information currently available
  • Regular blood tests are required for monitoring while on Prograf (tacrolimus).
  • Can cause a lot of side-effects, such as high blood sugar, high blood pressure, mental status changes, and kidney damage, especially with lifelong use.
  • Increases your risk of infection and certain cancers.
No information currently available
Used for
  • Prevention of heart transplant rejection
  • Prevention of liver transplant rejection
  • Prevention of kidney transplant rejection
  • Angiomyolipoma of kidney - Tuberous sclerosis syndrome
  • Not requiring immediate surgery Breast cancer
  • Advanced
  • Hormone receptor-positive
  • HER2 negative
  • In combination with exemestane after failure with letrozole or anastrozole Liver transplant rejection
  • Combination therapy; Prophylaxis Neuroendocrine tumor
  • Pancreatic
  • Unresectable
  • Locally advanced
  • Or metastatic disease Renal cell carcinoma
  • Advanced disease
  • After failure of treatment with sunitinib or sorafenib Renal transplant rejection
  • Low to moderate risk
  • Combination therapy; Prophylaxis Subependymal giant cell astrocytoma - Tuberous sclerosis syndrome
Dosage forms
  • Pill
  • Extended release
  • Injection
  • Pill
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Side effects
10possible side effects
  • High blood pressure
  • Kidney Function Abnormal
  • Anemia
  • Low white blood cells
  • Viral infection
  • Diabetes Mellitus
  • Infection
  • High blood sugar
  • High cholesterol
  • Bronchitis
See more detailed side effects
The Afinitor (Everolimus) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Serious infections

    Taking other immunosuppressant drugs

    ...and 2 more risk factors

  • Cancer

    Taking Prograf (tacrolimus) for a long time

  • Heart problems

    History of heart problems

    ...and 2 more risk factors

  • Kidney damage

    Poor kidney function

    ...and 2 more risk factors

  • Diabetes

    African-American descent

    ...and 1 more risk factors

  • Increased risk of death in female liver transplant patients taking extended-release Prograf (tacrolimus)

    Females using Astagraf XL

    ...and 1 more risk factors

See more detailed risks and warnings
No information currently available