Compare Prograf vs. Rapamune

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Prograf
(tacrolimus)

Rapamune
(Sirolimus)

Prevents rejection of a transplanted organ. Prograf (tacrolimus) is a good medicine that prevents rejection of an organ transplant, but you will need to be on it lifelong.Coming soon.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Prograf (tacrolimus)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Rapamune (Sirolimus)?
Worth itNot sureNot worth it
Side effects
PrografRapamune
  • Urinary Tract Infection 16%
  • Producing small amount of urine 18%
  • Constipation 24%
  • Low blood platelet count 24%
  • Rash 24%
  • Swelling all over body 26%
  • Vomiting 27%
  • Extra fluid in the stomach 27%
  • Low blood potassium 28%
  • Partial collapse of lung 28%
More Prograf side effects »

We haven’t found good data for Rapamune side effects.

FDA side effect reports for Rapamune »
How it works
PrografRapamune
Prograf (tacrolimus) is an immunosuppresant that lowers the activity of your immune system, so it doesn't attack the transplanted organ.Coming soon.
Type of medication
PrografRapamune
Prescription onlyLower-cost generic availableLower-cost generic available
Available as
PrografRapamune
  • Pill
  • Extended release
  • Injection
  • Pill
  • Liquid
Used for
PrografRapamune
  • Prevention Of Heart Transplant Rejection
  • Renal Transplant Rejection
Risk factors for serious side effects
PrografRapamune
  • Taking other immunosuppressant drugs
  • Age 60 or older
  • Weak immune system
  • Taking Prograf (tacrolimus) for a long time
  • History of heart problems
Detailed Prograf (tacrolimus) risks & warnings »
    Coming soon.
    Pregnancy

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Kidneys and liver
    PrografRapamune
    • Prograf (tacrolimus) can cause kidney damage, especially in patients with poor kidney function, or who are taking other drugs that can damage the kidneys. Your doctor will order blood tests to check your kidney function and Prograf (tacrolimus) levels, and will change your dose if needed.
    • Can cause a lot of side-effects, such as high blood sugar, high blood pressure, mental status changes, and kidney damage, especially with lifelong use.
    No kidneys and liver related info.
    Upsides and benefits
    PrografRapamune
    • Prevents your body from rejecting a transplanted organ.
    • Available as an extended-release pill, so it can be taken just once daily.
    • Less cosmetic side-effects than other anti-rejection medicine like cyclosporine.
    Coming soon
    Downsides and risks
    PrografRapamune
    • Regular blood tests are required for monitoring while on Prograf (tacrolimus).
    • Can cause a lot of side-effects, such as high blood sugar, high blood pressure, mental status changes, and kidney damage, especially with lifelong use.
    • Increases your risk of infection and certain cancers.
    Coming soon
    Tips from our pharmacists for people taking the medication
    PrografRapamune
    • Take your anti-rejection medicine consistently and at the same time each day.
    • It is important to check with your doctor before starting any other medicines, vitamins, or supplements to make sure it doesn't interfere with how your anti-rejection medicines work.
    • You will be more likely to catch an infection so practice good hand hygiene and avoid close contact with people who are sick. Also, wear gloves when you garden, keep any wounds clean and covered, and avoid sharing towels.
    • Can make you burn easily so wear protective clothing and sunblock if you have to be out in the sun.
    • Avoid grapefruit or grapefruit juice while on Prograf (tacrolimus).
    • You will need to get blood tests done regularly to make sure the drug is working properly.
    Coming soon
    Learn more
    More about PrografSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Prograf (tacrolimus)?
    Worth itNot sureNot worth it
    More about RapamuneSide effectsReviews & ratingsFDA package insert
    Have you used Rapamune (Sirolimus)?
    Worth itNot sureNot worth it