Compare Prograf vs. Rapamune

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Hecoria
(Tacrolimus)

Rapamune
(Sirolimus)

Prevents organ transplant rejection. Hecoria (Tacrolimus) is a good medication that prevents rejection of an organ transplant, but there are a lot of rules to follow while taking it.Coming soon.
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Reviews & ratings
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Have you used Hecoria (Tacrolimus)?
Worth itNot sureNot worth it

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Have you used Rapamune (Sirolimus)?
Worth itNot sureNot worth it
Side effects
PrografRapamune

The Prograf FDA package insert doesn’t have numbers about how common side effects are.

More about Prograf side effects »

We haven’t found good data for Rapamune side effects.

FDA side effect reports for Rapamune »
How it works
PrografRapamune
Hecoria (Tacrolimus) is an immunosuppresant that lowers the activity of your immune system, so it doesn't attack the transplanted organ.Coming soon.
Type of medication
PrografRapamune
Immunosuppressant
Calcineurin inhibitor
Prescription only
Coming soon.
Available as
PrografRapamune
  • Pill
  • Extended release
  • Pill
  • Liquid
Used for (click to learn more)
PrografRapamune
  • Renal transplant rejection
Risk factors for serious side effects
PrografRapamune
  • Taking other immunosuppressant drugs
  • Age 60 or older
  • Weak immune system
    • History of heart problems
    • Drug interactions
      • African-American descent
      • Hispanic descent
      • Kidney transplant patients
      • Poor kidney function
      • Taking kidney-damaging drugs
      Detailed Hecoria (Tacrolimus) risks & warnings »
      Coming soon.
      Pregnancy

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Food
      PrografRapamune
      • Immediate-release capsules can be taken with or without food, just be consistent in how you take it. Extended-release capsules should be taken on an empty stomach, 1 hour before or 2 hours after food.
      No food related info.
      Kidneys and liver
      PrografRapamune
      • Comes with potentially serious side effects like kidney damage, seizures, tremor, and hallucinations.
      • Kidney damage can occur when Hecoria (Tacrolimus) is used in high doses, especially in patients with impaired kidney function, or with other damaging (nephrotoxic) drugs like Sirolimus, Cyclosporine.
      No kidneys and liver related info.
      Weight
      PrografRapamune
      • Hecoria (Tacrolimus) can increase your risk of serious or life-threatening bacterial, fungal, and viral infections. In some cases, infections can be reactivated from an inactive virus in your body like tuberculosis (TB) or hepatitis B virus (HBV). If you develop symptoms of fever, chills, muscle aches, or you notice dark urine, appetite/weight loss, vomiting, or a skin rash, tell your doctor and get medical care right away.
      No weight related info.
      Upsides and benefits
      PrografRapamune
      • 96% of patients using Hecoria (Tacrolimus) maintained healthy organ transplants.
      • Can be taken by mouth within 24 hours of a transplant, helping reduce the complications of a lengthy hospital stay.
      • Patients taking Hecoria (Tacrolimus) had fewer heart problems than those taking similar medications.
      • Comes as an extended-release capsule, so it can be taken just once a day.
      • Hecoria (Tacrolimus) doesn't cause hirsutism (unexpected hair growth) or gum overgrowth like Cyclosporine.
      Coming soon
      Downsides and risks
      PrografRapamune
      • Regular blood tests are needed, especially in the beginning, to make sure Hecoria (Tacrolimus) isn't affecting your body in a bad way.
      • 20% of patients need insulin to control their blood sugar while taking Hecoria (Tacrolimus).
      • Comes with potentially serious side effects like kidney damage, seizures, tremor, and hallucinations.
      • You'll likely need to take corticosteroids with Hecoria (Tacrolimus).
      • Similar immunosuppressant medications can have fewer side effects.
      • Hecoria (Tacrolimus), like all immunosuppressants increases your risk of infection and certain cancers.
      Coming soon
      Tips from our pharmacists for people taking the medication
      PrografRapamune
      • Immediate-release capsules can be taken with or without food, just be consistent in how you take it. Extended-release capsules should be taken on an empty stomach, 1 hour before or 2 hours after food.
      • When getting a transplant, you'll be given several medications. To reduce side effects and interactions, be sure to tell your doctor about any other medications or vitamins you're taking.
      • Hecoria (Tacrolimus) and other immunosuppressants can lower your body's ability to fight infection. It's important that you practice good hygiene, avoid close contact with people who are sick, wear gloves when you garden, keep any cuts clean and covered, and avoid sharing towels or sponges.
      • Don't be out in the sun for too long since you're more likely to get sunburned and increase the risk of skin cancer. Wear protective clothing and sunblock if you have to be out.
      • Let your doctor know about any flu-like symptoms, muscle weakness or cramps, irregular heart beat, changes in eyesight, or if you're not urinating like you normally do.
      Coming soon
      Learn more
      More about PrografSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Hecoria (Tacrolimus)?
      Worth itNot sureNot worth it
      More about RapamuneSide effectsFDA package insert
      Have you used Rapamune (Sirolimus)?
      Worth itNot sureNot worth it