Compare Prolia vs. Actonel

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Prolia (Denosumab)

Prescription only

Actonel (risedronate)

Prescription only
Prevents bone loss.

Prolia (Denosumab) is an effective and convenient treatment for osteoporosis if other options haven’t worked or aren’t appropriate for you. There’re risks of some rare side effects, so make sure you're following up with your doctor regularly.

4.9/ 7 average rating with 15 reviewsforProlia
Prevents bone loss and fracture.

Actonel (risedronate) is a first-choice treatment for osteoporosis, but taking it can be a hassle.

3.8/ 7 average rating with 83 reviewsforActonel
Upsides
  • Prolia (Denosumab) is effective at preventing bone loss, making your bones stronger and lowering your chance of getting a fracture.
  • Only need to get an injection every 6 months, so you don’t have to remember to take something every day.
  • Actonel (risedronate) is one of the first choice medicines used for the treatment and prevention of osteoporosis.
  • Available in a cheaper, generic form.
  • Can take tablet form once or twice a month, once a week, or once a day.
Downsides
  • Approved for women only after they’ve reached menopause. Don’t use this if you’re pregnant or planning to become pregnant.
  • Can lower blood calcium levels. You might need to take calcium supplements to prevent this.
  • Not available as a generic.
  • Need to take Actonel (risedronate) on an empty stomach first thing in the morning with a full glass of water.
  • Requires the person taking this medicine to remain upright for at least 30 minutes after taking it, which can be a problem for those who have trouble sitting or standing.
Used for
Dosage forms
  • Injection
  • Pill
  • Delayed-release pill
Price
Lowest price near you
$2204.82
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$66.3
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Reviews
15 
33%
think this treatment is worth it
40%
think this treatment works well
27%
think this treatment is a hassle

Have you used Prolia (Denosumab)?

Leave a review
83 
36%
think this treatment is worth it
19%
think this treatment works well
25%
think this treatment is a hassle

Have you used Actonel (risedronate)?

Leave a review
Side effects
10possible side effects
  • Back pain
    35%
  • Pain in extremity
    12%
  • Musculoskeletal pain
    8%
  • Hypercholesterolemia
    7%
  • Cystitis
    6%
  • Vertigo
    5%
  • Edema peripheral
    5%
  • Upper respiratory tract infection
    5%
  • Sciatica
    5%
  • Pneumonia
    4%
See more detailed side effects
10possible side effects
  • Infection
    31%
  • Back pain
    28%
  • Joint pain
    24%
  • Accidental injury
    17%
  • Generalized pain
    14%
  • Constipation
    13%
  • Stomach pain
    12%
  • Traumatic bone fracture
    12%
  • Flu-like symptoms
    11%
  • High blood pressure
    11%
See more detailed side effects
Risks and warnings
  • Leg bone fractures

    Taking steroids

  • Low calcium blood levels

    Kidney problems

    ...and 3 more risk factors

  • Infection

    Weak immune system

    ...and 1 more risk factors

  • Problems in the jaw bone

    Oral or dental surgery

    ...and 3 more risk factors

See more detailed risks and warnings
  • Irritation and ulcers in the stomach and esophagus

    History of ulcers, or other stomach or esophageal problems

    ...and 2 more risk factors

  • Problems in the jawbone

    Oral or dental surgery

    ...and 2 more risk factors

  • Low calcium in the blood

    History of low calcium in the blood

See more detailed risks and warnings