Compare Prolia vs. calcitonin

Head-to-head comparisons of medication uses, side effects, ratings, and more.



Prevents bone loss. Prolia (Denosumab) is an effective and convenient treatment for osteoporosis if other options haven’t worked or aren’t appropriate for you. There’re risks of some rare side effects, so make sure you're following up with your doctor regularly.Coming soon.
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Reviews & ratings
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Have you used Prolia (Denosumab)?
Worth itNot sureNot worth it

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Have you used Miacalcin (Calcitonin)?
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Side effects
  • Hypercholesterolemia 1%
  • Ankle and leg swelling 1%
  • Ear, nose, or throat infection 1%
  • Sciatica 1%
  • Bone pain 1%
  • Passing gas 1%
  • Muscle pain 1%
  • Heart-related chest pain 1%
  • Rash 1%
  • Pain in extremity 1%
More Prolia side effects »

We haven’t found good data for calcitonin side effects.

FDA side effect reports for calcitonin »
How it works
Prolia (Denosumab) is a monoclonal antibody. It blocks a protein that sends signals to break down your bones, and therefore prevents bone loss.Coming soon.
Type of medication
Monoclonal antibodyPrescription only
Coming soon.
Available as
  • Injection
  • Nasal spray
Used for (click to learn more)
  • Hypercalcemia Paget's disease Postmenopausal osteoporosis
Risk factors for serious side effects
  • Taking steroids
    • Kidney problems
    • Not taking calcium supplements
    • Taking other medicines that can lower calcium blood levels
    • History of hypoparathyroidism (low levels of parathyroid hormone)
    • Weak immune system
    • Taking medicines that block your immune system (such as transplant medications or steroids)
    • Oral or dental surgery
    • Cancer diagnosis
    • Taking steroids or chemotherapy
    • Poor oral hygiene
      Detailed Prolia (Denosumab) risks & warnings »
      Coming soon.
      Pregnancy category
      XFDA pregnancy category (Unsafe)

      Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

      See the FDA package insert
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      Upsides and benefits
      • Prolia (Denosumab) is effective at preventing bone loss, making your bones stronger and lowering your chance of getting a fracture.
      • Only need to get an injection every 6 months, so you don’t have to remember to take something every day.
      Coming soon.
      Downsides and risks
      • Approved for women only after they’ve reached menopause. Don’t use this if you’re pregnant or planning to become pregnant.
      • Can lower blood calcium levels. You might need to take calcium supplements to prevent this.
      • Not available as a generic.
      Coming soon.
      Tips from our pharmacists for people taking the medication
      • Remember to get your shot every 6 months. Write it down on your calendar.
      • If your doctor also told you to take calcium and vitamin D, remember to take them as well. They'll work with Prolia (Denosumab) to help protect your bones.
      • Can cause skin irritation, joint pain, limb pain, and back pain.
      • Let your doctor know if you start getting more infections.
      • Let your dentist know that you’re taking Prolia (Denosumab) since it can cause problems in the jaw bone after dental procedures.
      Coming soon.
      Learn more
      More about ProliaSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Prolia (Denosumab)?
      Worth itNot sureNot worth it
      More about calcitoninSide effectsFDA package insert
      Have you used Miacalcin (Calcitonin)?
      Worth itNot sureNot worth it