Compare Prolia vs. calcitonin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Prolia (Denosumab)

Prescription only

Miacalcin (calcitonin)

Prescription only
Prevents bone loss.

Prolia (Denosumab) is an effective and convenient treatment for osteoporosis if other options haven’t worked or aren’t appropriate for you. There’re risks of some rare side effects, so make sure you're following up with your doctor regularly.

3.6/ 5 average rating with 15 reviewsforProlia
Treats high calcium levels and prevents bone loss.

Miacalcin (calcitonin) can be used for osteoporosis, but it is not a first choice because there are more effective medications available.

Upsides
  • Prolia (Denosumab) is effective at preventing bone loss, making your bones stronger and lowering your chance of getting a fracture.
  • Only need to get an injection every 6 months, so you don’t have to remember to take something every day.
  • Using the nasal spray causes fewer side effects than the injectable version.
  • Can help with bone pain if you've had a recent fracture.
  • Available in generic.
Downsides
  • Approved for women only after they’ve reached menopause. Don’t use this if you’re pregnant or planning to become pregnant.
  • Can lower blood calcium levels. You might need to take calcium supplements to prevent this.
  • Not available as a generic.
  • Miacalcin (calcitonin) is not as effective as other medications used to stop bone loss or lower calcium levels.
  • You're at a higher risk for certain cancers while taking Miacalcin (calcitonin).
  • If you're allergic to fish, you might also be allergic to Miacalcin (calcitonin).
Used for
Dosage forms
  • Injection
  • Nasal spray
  • Injection
Price
Lowest price
$2204.82
Find instant savings near you
Want to save even more money?
Sign up now for a 30-day trial and save up to 95% at CVS, Kroger, Albertsons, and other pharmacies.
Reviews
15 reviews so far
33%
saidit'sworth it
40%
saiditworked well
27%
saidit'sa big hassle

Have you used Prolia (Denosumab)?

Leave a review
Not enough review data.Leave a review
Side effects
27possible side effects
  • Back pain
    35%
  • Pain in extremity
    12%
  • Musculoskeletal pain
    8%
  • Hypercholesterolemia
    7%
  • Cystitis
    6%
  • Vertigo
    5%
  • Edema peripheral
    5%
  • Upper respiratory tract infection
    5%
  • Sciatica
    5%
  • Pneumonia
    4%
  • Bone pain
    4%
  • Anemia
    3%
  • Angina pectoris
    3%
  • Abdominal pain upper
    3%
  • Myalgia
    3%
  • Insomnia
    3%
  • Rash
    3%
  • Atrial fibrillation
    2%
  • Flatulence
    2%
  • Gastroesophageal reflux disease
    2%
  • Asthenia
    2%
  • Pharyngitis
    2%
  • Herpes zoster
    2%
  • Spinal osteoarthritis
    2%
  • Pruritus
    2%
  • Mortality
    2%
  • Adverse events
    2%
See more detailed side effects
The Miacalcin (calcitonin) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Leg bone fractures
    • Taking steroids
  • Hypersensitivity (allergic) reactions
  • Low calcium blood levels
    • Kidney problems
    • Not taking calcium supplements
    • Taking other medicines that can lower calcium blood levels
    • History of hypoparathyroidism (low levels of parathyroid hormone)
  • Infection
    • Weak immune system
    • Taking medicines that block your immune system (such as transplant medications or steroids)
  • Problems in the jaw bone
    • Oral or dental surgery
    • Cancer diagnosis
    • Taking steroids or chemotherapy
    • Poor oral hygiene
  • Pain in the bones and muscles
See more detailed risks and warnings
  • Allergic reaction
    • Allergy to fish
  • Seizures
    • Seizure history
    • Low calcium in blood
  • Nasal problems
    • Age 65 and above
  • Cancer
    • History of cancer
See more detailed risks and warnings