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Prevents bone loss. Prolia (Denosumab) is an effective and convenient treatment for osteoporosis if other options haven’t worked or aren’t appropriate for you. There’re risks of some rare side effects, so make sure you're following up with your doctor regularly.Coming soon.
How it works
Prolia (Denosumab) is a monoclonal antibody. It blocks a protein that sends signals to break down your bones, and therefore prevents bone loss.Coming soon.
Type of medication
Monoclonal antibodyPrescription only
Coming soon.
Available as
  • Injection
  • Nasal spray
Used for (click to learn more)
  • Hypercalcemia Paget's disease Postmenopausal osteoporosis
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Reviews & ratings
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Side effects
  • Hypercholesterolemia 1%
  • Ankle and leg swelling 1%
  • Ear, nose, or throat infection 1%
  • Sciatica 1%
  • Bone pain 1%
  • Passing gas 1%
  • Muscle pain 1%
  • Heart-related chest pain 1%
  • Rash 1%
  • Pain in extremity 1%
More Prolia side effects »

We haven’t found good data for calcitonin side effects.

FDA side effect reports for calcitonin »
Risk factors for serious side effects
  • Coming soon.
Pregnancy category
No specific alcohol-related info.No specific alcohol-related info.
No specific food-related info.No specific food-related info.
Kidneys and liver
No specific kidneys and liver-related info.No specific kidneys and liver-related info.
No specific sex-related info.No specific sex-related info.
No specific sleep-related info.No specific sleep-related info.
No specific weight-related info.No specific weight-related info.
Upsides and benefits
  • Prolia (Denosumab) is effective at preventing bone loss, making your bones stronger and lowering your chance of getting a fracture.
  • Only need to get an injection every 6 months, so you don’t have to remember to take something every day.
Coming soon.
Downsides and risks
  • Approved for women only after they’ve reached menopause. Don’t use this if you’re pregnant or planning to become pregnant.
  • Can lower blood calcium levels. You might need to take calcium supplements to prevent this.
  • Not available as a generic.
Coming soon.
Tips from our pharmacists for people taking the medication
  • Remember to get your shot every 6 months. Write it down on your calendar.
  • If your doctor also told you to take calcium and vitamin D, remember to take them as well. They'll work with Prolia (Denosumab) to help protect your bones.
  • Can cause skin irritation, joint pain, limb pain, and back pain.
  • Let your doctor know if you start getting more infections.
  • Let your dentist know that you’re taking Prolia (Denosumab) since it can cause problems in the jaw bone after dental procedures.
Coming soon.
Learn more
More about ProliaSide effectsReviews & ratingsAlternativesFDA package insert
More about calcitoninSide effectsFDA package insert
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