Compare Prolia vs. Calcitonin

Head-to-head comparisons of medication uses, side effects, ratings, and more.



Prevents bone loss. Prolia (Denosumab) is an effective and convenient treatment for osteoporosis if other options haven’t worked or aren’t appropriate for you. There’re risks of some rare side effects, so make sure you're following up with your doctor regularly.Coming soon.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Coupons for Prolia
Best available price for 1 (1ml of 60mg/ml) syringe of prolia
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
Reviews for Prolia
of people (All ages) say Prolia is worth it
say it works well
say it's a big hassle
Have you used Prolia (denosumab)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Miacalcin (calcitonin)?
Worth itNot sureNot worth it
Side effects
  • Pain in extremity 1%
  • Hypercholesterolemia 1%
  • Ankle and leg swelling 1%
  • Ear, nose, or throat infection 1%
  • Sciatica 1%
More Prolia side effects »

We haven’t found good data for Calcitonin side effects.

FDA side effect reports for Calcitonin »
How it works
Prolia (Denosumab) is a monoclonal antibody. It blocks a protein that sends signals to break down your bones, and therefore prevents bone loss.Coming soon.
Type of medication
Prescription only
Available as
  • Injection
  • Nasal spray
Used for
  • Hypercalcemia Pagets Disease Postmenopausal Osteoporosis
Risk factors for serious side effects
  • Taking steroids
  • Kidney problems
  • Not taking calcium supplements
  • Taking other medicines that can lower calcium blood levels
  • History of hypoparathyroidism (low levels of parathyroid hormone)
Detailed Prolia (denosumab) risks & warnings »
    Coming soon.

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    • Can cause skin irritation, joint pain, limb pain, and back pain.
    No pain related info.
    Upsides and benefits
    • Prolia (Denosumab) is effective at preventing bone loss, making your bones stronger and lowering your chance of getting a fracture.
    • Only need to get an injection every 6 months, so you don’t have to remember to take something every day.
    Coming soon
    Downsides and risks
    • Approved for women only after they’ve reached menopause. Don’t use this if you’re pregnant or planning to become pregnant.
    • Can lower blood calcium levels. You might need to take calcium supplements to prevent this.
    • Not available as a generic.
    Coming soon
    Tips from our pharmacists for people taking the medication
    • Remember to get your shot every 6 months. Write it down on your calendar.
    • If your doctor also told you to take calcium and vitamin D, remember to take them as well. They'll work with Prolia (Denosumab) to help protect your bones.
    • Can cause skin irritation, joint pain, limb pain, and back pain.
    • Let your doctor know if you start getting more infections.
    • Let your dentist know that you’re taking Prolia (Denosumab) since it can cause problems in the jaw bone after dental procedures.
    Coming soon
    Learn more
    More about ProliaSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Prolia (denosumab)?
    Worth itNot sureNot worth it
    More about CalcitoninSide effectsFDA package insert
    Have you used Miacalcin (calcitonin)?
    Worth itNot sureNot worth it