Compare Prolia vs. Evista

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Prolia
(Denosumab)

Evista
(Raloxifene)

Prevents bone loss. Prolia (Denosumab) is an effective and convenient treatment for osteoporosis if other options haven’t worked or aren’t appropriate for you. There’re risks of some rare side effects, so make sure you're following up with your doctor regularly.Prevents bone loss and lowers your risk of breast cancer. Evista (Raloxifene) is effective at reducing bone loss and lowering the risk of breast cancer in postmenopausal women, but does carry the risk of blood clots.
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Reviews & ratings
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Side effects
ProliaEvista
  • Hypercholesterolemia 1%
  • Ankle and leg swelling 1%
  • Ear, nose, or throat infection 1%
  • Sciatica 1%
  • Bone pain 1%
  • Passing gas 1%
  • Muscle pain 1%
  • Heart-related chest pain 1%
  • Rash 1%
  • Pain in extremity 1%
More Prolia side effects »
  • Muscle spasms/leg cramps 4%
  • Leg cramps 3%
  • Sinus inflammation 3%
  • Leg or ankle swelling 2%
  • Muscle pain 2%
  • Sleep difficulty 2%
  • Rash 2%
  • Joint pain 2%
  • Weight gain 2%
  • Any side effect 1%
More Evista side effects »
How it works
ProliaEvista
Prolia (Denosumab) is a monoclonal antibody. It blocks a protein that sends signals to break down your bones, and therefore prevents bone loss.Evista (Raloxifene) is a selective estrogen receptor modulator (SERM). It acts like estrogen to make your bones stronger and less likely to break, and also protects breast and uterus tissues from other estrogen effects.
Type of medication
ProliaEvista
Monoclonal antibodyPrescription only
Osteoporosis
Selective estrogen receptor modulator
Prescription only
Available as
ProliaEvista
  • Injection
  • Pill
Used for (click to learn more)
ProliaEvista
Risk factors for serious side effects
ProliaEvista
  • Taking steroids
    • Kidney problems
    • Not taking calcium supplements
    • Taking other medicines that can lower calcium blood levels
    • History of hypoparathyroidism (low levels of parathyroid hormone)
    • Weak immune system
    • Taking medicines that block your immune system (such as transplant medications or steroids)
    • Oral or dental surgery
    • Cancer diagnosis
    • Taking steroids or chemotherapy
    • Poor oral hygiene
      Detailed Prolia (Denosumab) risks & warnings »
      • History of stroke
      • Heart and blood vessel problems
      • History of mini stroke (TIA)
      • Atrial fibrillation
      • Smoking
      • High blood pressure
        • History of high triglycerides
          Detailed Evista (Raloxifene) risks & warnings »
          Pregnancy category
          ProliaEvista
          Alcohol
          No specific alcohol-related info.
          • Regular exercise, cutting back on smoking, and drinking less alcohol can also reduce your risk of bone loss.
          Food
          No specific food-related info.
          • Take 1 tablet daily with or without food about the same time each day. It’s important to read the information you get with your medicine about how to take Evista (Raloxifene).
          Kidneys and liver
          No specific kidneys and liver-related info.
          • Evista (Raloxifene) is processed by the kidney and liver. If you have kidney or liver problems, talk to your doctor because you may need a different dose.
          Sex
          No specific sex-related info.No specific sex-related info.
          Sleep
          No specific sleep-related info.No specific sleep-related info.
          Weight
          No specific weight-related info.No specific weight-related info.
          Upsides and benefits
          ProliaEvista
          • Prolia (Denosumab) is effective at preventing bone loss, making your bones stronger and lowering your chance of getting a fracture.
          • Only need to get an injection every 6 months, so you don’t have to remember to take something every day.
          • Evista (Raloxifene) doesn’t affect the breast or uterus the same way that estrogen does, so the risk of cancer is much lower.
          • Taking Evista (Raloxifene) with calcium and vitamin D improves spine and hip bone health and lowers the risk of fractures.
          • Lowers total cholesterol and low-density lipoprotein (LDL) cholesterol (the bad cholesterol).
          Downsides and risks
          ProliaEvista
          • Approved for women only after they’ve reached menopause. Don’t use this if you’re pregnant or planning to become pregnant.
          • Can lower blood calcium levels. You might need to take calcium supplements to prevent this.
          • Not available as a generic.
          • Can only take Evista (Raloxifene) once you’re in menopause. You can't take it if you're pregnant or breastfeeding.
          • Evista (Raloxifene) isn’t as effective as tamoxifen at lowering the risk of invasive breast cancer.
          • Shouldn’t take it with any other forms of estrogen (pills, patches, or injection).
          • It doesn’t increase bone strength as much as estrogen does and isn’t effective for treating hot flashes.
          Tips from our pharmacists for people taking the medication
          ProliaEvista
          • Remember to get your shot every 6 months. Write it down on your calendar.
          • If your doctor also told you to take calcium and vitamin D, remember to take them as well. They'll work with Prolia (Denosumab) to help protect your bones.
          • Can cause skin irritation, joint pain, limb pain, and back pain.
          • Let your doctor know if you start getting more infections.
          • Let your dentist know that you’re taking Prolia (Denosumab) since it can cause problems in the jaw bone after dental procedures.
          • Take 1 tablet daily with or without food about the same time each day. It’s important to read the information you get with your medicine about how to take Evista (Raloxifene).
          • Your doctor may tell you to take calcium and vitamin D with Evista (Raloxifene) to prevent osteoporosis (bone thinning and loss), especially if you don’t get enough in your diet.
          • Regular exercise, cutting back on smoking, and drinking less alcohol can also reduce your risk of bone loss.
          Learn more
          More about ProliaSide effectsReviews & ratingsAlternativesFDA package insert
          More about EvistaSide effectsReviews & ratingsAlternativesFDA package insert