Compare Prolia vs. Evista

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Prolia (Denosumab)

Prescription only

Evista (Raloxifene)

Prescription only
Prevents bone loss.

Prolia (Denosumab) is an effective and convenient treatment for osteoporosis if other options haven’t worked or aren’t appropriate for you. There’re risks of some rare side effects, so make sure you're following up with your doctor regularly.

4.9/ 7 average rating with 15 reviewsforProlia
Prevents bone loss and lowers your risk of breast cancer.

Evista (Raloxifene) is effective at reducing bone loss and lowering the risk of breast cancer in postmenopausal women, but does carry the risk of blood clots.

  • Prolia (Denosumab) is effective at preventing bone loss, making your bones stronger and lowering your chance of getting a fracture.
  • Only need to get an injection every 6 months, so you don’t have to remember to take something every day.
  • Evista (Raloxifene) doesn’t affect the breast or uterus the same way that estrogen does, so the risk of cancer is much lower.
  • Taking Evista (Raloxifene) with calcium and vitamin D improves spine and hip bone health and lowers the risk of fractures.
  • Lowers total cholesterol and low-density lipoprotein (LDL) cholesterol (the bad cholesterol).
  • Approved for women only after they’ve reached menopause. Don’t use this if you’re pregnant or planning to become pregnant.
  • Can lower blood calcium levels. You might need to take calcium supplements to prevent this.
  • Not available as a generic.
  • Can only take Evista (Raloxifene) once you’re in menopause. You can't take it if you're pregnant or breastfeeding.
  • Evista (Raloxifene) isn’t as effective as tamoxifen at lowering the risk of invasive breast cancer.
  • Shouldn’t take it with any other forms of estrogen (pills, patches, or injection).
  • It doesn’t increase bone strength as much as estrogen does and isn’t effective for treating hot flashes.
Used for
Dosage forms
  • Injection
  • Pill
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Side effects
10possible side effects
  • Back pain
  • Pain in extremity
  • Musculoskeletal pain
  • Hypercholesterolemia
  • Cystitis
  • Vertigo
  • Edema peripheral
  • Upper respiratory tract infection
  • Sciatica
  • Pneumonia
See more detailed side effects
6possible side effects
  • Any side effect
  • Peripheral edema
  • Muscle spasms/leg cramps
  • Hot Flashes
  • Cholelithiasis
  • Venous thromboembolic events
See more detailed side effects
Risks and warnings
  • Leg bone fractures

    Taking steroids

  • Low calcium blood levels

    Kidney problems

    ...and 3 more risk factors

  • Infection

    Weak immune system

    ...and 1 more risk factors

  • Problems in the jaw bone

    Oral or dental surgery

    ...and 3 more risk factors

See more detailed risks and warnings
  • Increased risk of stroke

    History of stroke

    ...and 5 more risk factors

  • Elevated triglycerides (fats in blood)

    History of high triglycerides

See more detailed risks and warnings