Compare Propranolol vs. baclofen

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Inderal (Propranolol)

Prescription only

Lioresal (baclofen)

Prescription only
Lowers blood pressure and controls heart rate.

Inderal (Propranolol) is good for treating many heart problems and other problems in the body, but it has more side effects than other beta blockers. You can't miss doses.

5.4/ 7 average rating with 61 reviewsforPropranolol
Relaxes your muscles.

Lioresal (baclofen) is a first choice treatment for muscle spasticity caused by multiple sclerosis or spinal cord injuries, but it's not recommended for other types of muscle spasms.

4.8/ 7 average rating with 33 reviewsforbaclofen
Upsides
  • A first-choice treatment to prevent chest pain (angina).
  • A first-choice treatment for heart failure, heart attack, heart valve disorders, and abnormal heart rhythm.
  • Also treats and prevents many non-heart problems, such as tremors, anxiety, migraines, and liver disease symptoms.
  • A better option for seniors compared to other muscle relaxants since it has fewer side effects than other similar medicines.
  • Lioresal (baclofen) is available as a generic and is a relatively inexpensive medication.
Downsides
  • Taking a beta blocker might make you feel more tired or out of breath during exercise or normal daily routines. This gets better for most people, but for some might not go away.
  • Has more side effects than some beta blockers because it crosses into the brain and central nervous system.
  • Not a first-choice treatment for high blood pressure according to the latest guidelines, except if you have heart failure or heart disease. As a second choice, your doctor might add it to medicines you're already taking if your blood pressure is still too high.
  • Can hide symptoms of low blood sugar if you're diabetic.
  • You can't miss doses. Stopping Propranolol suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
  • Except for specific muscle spasms caused by brain injury or multiple sclerosis, Lioresal (baclofen) is not a recommended medicine.
  • If you've been taking Lioresal (baclofen) regularly for a long time, you'll need to get off of it slowly.
  • Lioresal (baclofen) can make you sleepy.
  • If you've had a stroke, Lioresal (baclofen) may not work as well, and you're more likely to experience side effects.
Used for
Dosage forms
  • Pill
  • Extended release
  • Liquid
  • Pill
Price
Lowest price near you
$9.99
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Lowest price near you
$9.99
Find instant savings
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Reviews
61 
66%
think this treatment is worth it
62%
think this treatment works well
15%
think this treatment is a hassle

Have you used Inderal (Propranolol)?

Leave a review
33 
61%
think this treatment is worth it
55%
think this treatment works well
15%
think this treatment is a hassle

Have you used Lioresal (baclofen)?

Leave a review
Side effects
3possible side effects
  • Dizziness
    7%
  • Fatigue
    5%
  • Constipation
    3%
See more detailed side effects
1possible side effects
  • Drowsiness
    63%
See more detailed side effects
Risks and warnings
  • Increased chest pain or risk of heart attack

    Suddenly stopping Inderal (Propranolol)

  • Increased risks during surgery

    Major surgery requiring anesthesia

  • Masked symptoms of low blood sugar

    Diabetes

  • Low blood pressure

    Concurrent use of non-dihydropyridine calcium channel blockers, digoxin or clonidine

See more detailed risks and warnings
  • Withdrawal symptoms

    Stopping Lioresal (baclofen) too quickly

  • Driving impairment

    Taking with alcohol

    ...and 2 more risk factors

  • Seizures

    Higher dose

    ...and 5 more risk factors

See more detailed risks and warnings