Compare Propranolol vs. Bystolic

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Inderal
(Propranolol)

Bystolic
(Nebivolol)

Lowers blood pressure and controls heart rate. Inderal (Propranolol) is good for treating many heart problems and other problems in the body, but it has more side effects than other beta blockers. You can't miss doses.Lowers blood pressure and controls heart rate. Bystolic (Nebivolol) is a good blood pressure-lowering medicine for people with heart conditions, and has fewer side effects than other beta blockers, but it's expensive. You can't miss doses.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.39Propranolol
Reviews for Inderal (Propranolol)
66%
of people (All ages) say Inderal (Propranolol) is worth it
62%
say it works well
15%
say it's a big hassle
Have you used Inderal (Propranolol)?
Worth itNot sureNot worth it
Reviews for Bystolic (Nebivolol)
53%
13% vs. Inderal (Propranolol)
49%
13% vs. Inderal (Propranolol)
18%
3% vs. Inderal (Propranolol)
154 reviews
Have you used Bystolic (Nebivolol)?
Worth itNot sureNot worth it
Side effects
PropranololBystolic
  • Dizziness 5%
  • Fatigue 4%
More Propranolol side effects »
  • Fatigue 4%
  • Headache 3%
  • Dizziness 2%
  • Diarrhea 1%
More Bystolic side effects »
How it works
PropranololBystolic
Inderal (Propranolol) is an alpha and beta blocker. It lowers blood pressure by slowing heart rate, relaxing blood vessels, and lowering the body's fight-or-flight response.Bystolic (Nebivolol) is a selective beta blocker that works specifically on the heart. It lowers blood pressure by slowing down the heart and making it work less to pump.
Type of medication
PropranololBystolic
Antihypertensive
Beta blocker
Prescription only
Antihypertensive
Beta blocker
Prescription only
Available as
PropranololBystolic
  • Pill
  • Extended release
  • Liquid
  • Pill
Used for (click to learn more)
PropranololBystolic
Risk factors for serious side effects
PropranololBystolic
  • Suddenly stopping Inderal (Propranolol)
  • Major surgery requiring anesthesia
  • Diabetes
  • Concurrent use of non-dihydropyridine calcium channel blockers, digoxin or clonidine
Detailed risks & warnings »
  • Sudden discontinuation of medicine
  • History of asthma
  • History of diabetes
  • Age 65 years or older
  • Using other medicine(s) that slows the heart
Detailed risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Upsides and benefits
PropranololBystolic
  • A first-choice treatment to prevent chest pain (angina).
  • A first-choice treatment for heart failure, heart attack, heart valve disorders, and abnormal heart rhythm.
  • Also treats and prevents many non-heart problems, such as tremors, anxiety, migraines, and liver disease symptoms.
  • Controls your heart rate to reduce work for your heart.
  • A first-line treatment for heart failure and heart attack.
  • Helps to lower blood pressure if you can't use first-choice treatments or need additional blood pressure control.
  • Many beta blockers can worsen asthma or cause headaches, but Bystolic usually doesn't because it targets the heart more specifically and causes fewer side effects.
Downsides and risks
PropranololBystolic
  • Has more side effects than some beta blockers because it crosses into the brain and central nervous system.
  • Not a first-choice treatment for high blood pressure according to the latest guidelines, except if you have heart failure or heart disease. As a second choice, your doctor might add it to medicines you're already taking if your blood pressure is still too high.
  • You can't miss doses. Stopping Propranolol suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
  • Taking a beta blocker might make you feel more tired or out of breath during exercise or normal daily routines. This gets better for most people, but for some might not go away.
  • Can hide symptoms of low blood sugar if you're diabetic.
  • Not available in less expensive generic form.
  • You can't miss doses. Stopping Bystolic suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
  • Taking a beta blocker might make you feel more tired or out of breath during exercise or normal daily routines. This gets better for most people, but for some might not go away.
  • Can hide symptoms of low blood sugar if you're diabetic.
Tips from our pharmacists for people taking the medication
PropranololBystolic
  • Can cause dizziness in the first few days.
  • Can cause insomnia and fatigue.
  • Can hide symptoms of low blood sugar. Be careful if you're diabetic.
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
  • Don't stop taking this medicine suddenly.
  • Can cause headache, dizziness, or feeling short of breath in the first few days.
  • If side effects don't go away, talk to your doctor about alternatives.
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
  • Don't stop taking this medicine suddenly.
Learn more
More about PropranololSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Inderal (Propranolol)?
Worth itNot sureNot worth it
More about BystolicSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Bystolic (Nebivolol)?
Worth itNot sureNot worth it