Compare Propranolol vs. Depakote

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Inderal
(Propranolol)

Depacon
(Valproate, Valproic Acid, Or Divalproex)

Lowers blood pressure and controls heart rate. Inderal (Propranolol) is good for treating many heart problems and other problems in the body, but it has more side effects than other beta blockers. You can't miss doses.Prevents seizures and stabilizes mood. Depacon (Valproate, Valproic Acid, Or Divalproex) is good long-term prevention for epilepsy, bipolar disorder, and migraines, but can cause weight gain.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.264150943396227Propranolol
Reviews for Inderal (Propranolol)
62%
of people say Inderal (Propranolol) is worth it
58%
say it works well
17%
say it's a big hassle
Reviews for Depacon (Valproate, Valproic Acid, Or Divalproex)
46%
16% vs. Inderal (Propranolol)
39%
19% vs. Inderal (Propranolol)
27%
10% vs. Inderal (Propranolol)
Side effects
PropranololDepakote
  • Dizziness 5%
  • Fatigue 4%
More Propranolol side effects »
  • Nausea 34%
  • Muscle weakness 20%
  • Vomiting 20%
  • Abdominal pain 17%
  • Dizziness 12%
  • Headache 10%
  • Double vision 7%
  • Involuntary eye movement 7%
  • Lack of muscle coordination 7%
  • Accidental injury 6%
More Depakote side effects »
How it works
PropranololDepakote
Inderal (Propranolol) is an alpha and beta blocker. It lowers blood pressure by slowing heart rate, relaxing blood vessels, and lowering the body's fight-or-flight response.Depacon (Valproate, Valproic Acid, Or Divalproex) is an antiepileptic. Researchers don't know exactly how it works. It seems to increase the amount of GABA, a chemical that calms nerves in the brain.
Type of medication
PropranololDepakote
Antihypertensive
Beta blocker
Prescription only
AnticonvulsantPrescription only
Available as
PropranololDepakote
  • Pill
  • Extended release
  • Liquid
  • Pill
  • Extended release
  • Extended release capsule
  • Sprinkle
  • Liquid
Used for (click to learn more)
PropranololDepakote
Risk factors for serious side effects
PropranololDepakote
  • Suddenly stopping Inderal (Propranolol)
    • Major surgery requiring anesthesia
    • Diabetes
      • Concurrent use of non-dihydropyridine calcium channel blockers, digoxin or clonidine
        Detailed Inderal (Propranolol) risks & warnings »
          • Children under age 2
          • History of metabolic disorders
            • History of depression
              • History of metabolic disorders
              • People also taking Topamax
              • People also taking Topamax
                • Stopping Depacon (Valproate, Valproic Acid, Or Divalproex) suddenly
                Detailed Depacon (Valproate, Valproic Acid, Or Divalproex) risks & warnings »
                Pregnancy category
                PropranololDepakote
                CFDA pregnancy category (Weigh risks vs. benefits)

                Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                See the FDA package insert
                DFDA pregnancy category (Weigh risks vs. benefits)

                Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                See the FDA package insert
                Alcohol
                No specific alcohol-related info.No specific alcohol-related info.
                Food
                No specific food-related info.
                • Take with food to avoid upset stomach.
                Kidneys and liver
                No specific kidneys and liver-related info.No specific kidneys and liver-related info.
                Sex
                No specific sex-related info.No specific sex-related info.
                Sleep
                No specific sleep-related info.No specific sleep-related info.
                Weight
                • Cases of heart failure due to taking Inderal (Propranolol) have been reported. Tell your doctor if you noticed increased swelling around your legs or ankles, sudden weight gain or sudden shortness of breath as these may be symptoms of heart failure.
                • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
                • May cause hair loss and weight gain.
                Upsides and benefits
                PropranololDepakote
                • A first-choice treatment to prevent chest pain (angina).
                • A first-choice treatment for heart failure, heart attack, heart valve disorders, and abnormal heart rhythm.
                • Also treats and prevents many non-heart problems, such as tremors, anxiety, migraines, and liver disease symptoms.
                • Lowers the frequency of seizures, especially for people with absence, tonic-clonic, and complex partial seizures.
                • One of the first-line options to stabilize mood for people with bipolar disorder.
                • Helpful in preventing frequent migraine headaches.
                Downsides and risks
                PropranololDepakote
                • Taking a beta blocker might make you feel more tired or out of breath during exercise or normal daily routines. This gets better for most people, but for some might not go away.
                • Has more side effects than some beta blockers because it crosses into the brain and central nervous system.
                • Not a first-choice treatment for high blood pressure according to the latest guidelines, except if you have heart failure or heart disease. As a second choice, your doctor might add it to medicines you're already taking if your blood pressure is still too high.
                • Can hide symptoms of low blood sugar if you're diabetic.
                • You can't miss doses. Stopping Propranolol suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
                • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
                • Can cause liver damage, so it's probably not safe if you already have liver problems.
                • Not safe to use if you're pregnant.
                • Requires routine blood tests to see how the medicine is affecting your body.
                Tips from our pharmacists for people taking the medication
                PropranololDepakote
                • Can cause dizziness in the first few days.
                • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
                • Can cause insomnia and fatigue.
                • Can hide symptoms of low blood sugar. Be careful if you're diabetic.
                • Don't stop taking this medicine suddenly.
                • For the first week, avoid activities that require you to be alert.
                • Don't use if pregnant.
                • Requires routine blood tests.
                • Take with food to avoid upset stomach.
                • May cause hair loss and weight gain.
                • Different versions of Depakote have different dosing. Be careful.
                • Report confusion, persistent abdominal pain, yellowing of eyes/skin, or easy bruising to your doctor.
                • Takes 3 to 4 weeks to feel full effects on mood.
                Learn more
                More about PropranololSide effectsReviews & ratingsAlternativesFDA package insert
                More about DepakoteSide effectsReviews & ratingsAlternativesFDA package insert