Compare Propranolol vs. Hydrochlorothiazide

Head-to-head comparisons of medication uses, side effects, ratings, and more.


(Hydrochlorothiazide )

Lowers blood pressure and controls heart rate. Inderal (Propranolol) is good for treating many heart problems and other problems in the body, but it has more side effects than other beta blockers. You can't miss doses.Lowers blood pressure. Removes extra water from your body. Microzide (Hydrochlorothiazide (Hctz)) is a well-tolerated water pill that's often the first-choice treatment for mild high blood pressure.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
Reviews for Inderal (Propranolol)
of people say Inderal (Propranolol) is worth it
say it works well
say it's a big hassle
Reviews for Microzide (Hydrochlorothiazide (Hctz))
15% vs. Inderal (Propranolol)
27% vs. Inderal (Propranolol)
+2% vs. Inderal (Propranolol)
137 reviews
Side effects
  • Dizziness 5%
  • Fatigue 4%
More Propranolol side effects »

The Hydrochlorothiazide FDA package insert doesn’t have numbers about how common side effects are.

More about Hydrochlorothiazide side effects »
How it works
Inderal (Propranolol) is an alpha and beta blocker. It lowers blood pressure by slowing heart rate, relaxing blood vessels, and lowering the body's fight-or-flight response.Microzide (Hydrochlorothiazide (Hctz)) is a thiazide diuretic (water pill). It works in the kidneys to make you urinate more, which removes extra water and certain electrolytes. This lowers blood pressure and swelling.
Type of medication
Beta blocker
Prescription only
Prescription only
Available as
  • Pill
  • Extended release
  • Liquid
  • Pill
Used for (click to learn more)
Risk factors for serious side effects
  • Suddenly stopping Inderal (Propranolol)
    • Major surgery requiring anesthesia
    • Diabetes
      • Concurrent use of non-dihydropyridine calcium channel blockers, digoxin or clonidine
        Detailed Inderal (Propranolol) risks & warnings »
        • Current electrolyte imbalance
        • History of sulfa allergies
        • History of gout
        • Current kidney problems
          Detailed Microzide (Hydrochlorothiazide (Hctz)) risks & warnings »
          Pregnancy category
          CFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          BFDA pregnancy category (Probably safe)

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          See the FDA package insert
          No specific alcohol-related info.No specific alcohol-related info.
          No specific food-related info.No specific food-related info.
          Kidneys and liver
          No specific kidneys and liver-related info.
          • Doesn't work well in people with severe kidney problems.
          • Requires routine blood tests to check kidney function.
          No specific sex-related info.No specific sex-related info.
          No specific sleep-related info.No specific sleep-related info.
          • Cases of heart failure due to taking Inderal (Propranolol) have been reported. Tell your doctor if you noticed increased swelling around your legs or ankles, sudden weight gain or sudden shortness of breath as these may be symptoms of heart failure.
          No specific weight-related info.
          Upsides and benefits
          • A first-choice treatment to prevent chest pain (angina).
          • A first-choice treatment for heart failure, heart attack, heart valve disorders, and abnormal heart rhythm.
          • Also treats and prevents many non-heart problems, such as tremors, anxiety, migraines, and liver disease symptoms.
          • Works well to get rid of extra fluids in your body through urination.
          • A first-choice blood pressure treatment for many people. Works especially well for African Americans.
          • Lowers the risk of heart attack and stroke.
          • Good option if you have both high blood pressure and heart failure.
          • Raises calcium levels in the body, so it can be good for people with osteoporosis to slow down bone loss and even help with new bone formation.
          • Most people have very few side effects.
          Downsides and risks
          • Taking a beta blocker might make you feel more tired or out of breath during exercise or normal daily routines. This gets better for most people, but for some might not go away.
          • Has more side effects than some beta blockers because it crosses into the brain and central nervous system.
          • Not a first-choice treatment for high blood pressure according to the latest guidelines, except if you have heart failure or heart disease. As a second choice, your doctor might add it to medicines you're already taking if your blood pressure is still too high.
          • Can hide symptoms of low blood sugar if you're diabetic.
          • You can't miss doses. Stopping Propranolol suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
          • Makes you urinate more often.
          • Doesn't work well in people with severe kidney problems.
          Tips from our pharmacists for people taking the medication
          • Can cause insomnia and fatigue.
          • Can hide symptoms of low blood sugar. Be careful if you're diabetic.
          • Don't stop taking this medicine suddenly.
          • Can cause dizziness in the first few days.
          • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
          • Starts working in about 2 hours.
          • Makes you urinate more often, so avoid taking it at bedtime.
          • Tell your doctor about any dizziness, fatigue, or muscle weakness that doesn't go away.
          • Requires routine blood tests to check kidney function.
          • Can cause dizziness in the first few days.
          • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
          Learn more
          More about PropranololSide effectsReviews & ratingsAlternativesFDA package insert
          More about HydrochlorothiazideSide effectsReviews & ratingsAlternativesFDA package insert