Compare Propranolol vs. Lisinopril

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Inderal
(Propranolol)

Zestril
(Lisinopril)

Lowers blood pressure and controls heart rate. Inderal (Propranolol) is good for treating many heart problems and other problems in the body, but it has more side effects than other beta blockers. You can't miss doses.Lowers blood pressure. Zestril (Lisinopril) is a good blood pressure-lowering medicine that protects kidney function.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.264150943396227Propranolol
Reviews for Inderal (Propranolol)
62%
of people say Inderal (Propranolol) is worth it
58%
say it works well
17%
say it's a big hassle
Reviews for Zestril (Lisinopril)
61%
1% vs. Inderal (Propranolol)
51%
7% vs. Inderal (Propranolol)
13%
+4% vs. Inderal (Propranolol)
Side effects
PropranololLisinopril
  • Dizziness 5%
  • Fatigue 4%
More Propranolol side effects »
  • Dizziness 7%
  • Headache 4%
  • Cough 3%
  • Diarrhea 2%
  • Chest pain 2%
  • Fatigue 2%
  • Upper respiratory infection 1%
More Lisinopril side effects »
How it works
PropranololLisinopril
Inderal (Propranolol) is an alpha and beta blocker. It lowers blood pressure by slowing heart rate, relaxing blood vessels, and lowering the body's fight-or-flight response.Zestril (Lisinopril) is an angiotensin converting enzyme (ACE) inhibitor. It blocks a chemical that tightens blood vessels. This makes blood vessels relax, which lowers blood pressure and allows more blood and oxygen to get to your heart and other organs.
Type of medication
PropranololLisinopril
Antihypertensive
Beta blocker
Prescription only
Antihypertensive
ACE inhibitor
Prescription only
Available as
PropranololLisinopril
  • Pill
  • Extended release
  • Liquid
  • Pill
Used for (click to learn more)
PropranololLisinopril
Risk factors for serious side effects
PropranololLisinopril
  • Suddenly stopping Inderal (Propranolol)
    • Major surgery requiring anesthesia
    • Diabetes
      • Concurrent use of non-dihydropyridine calcium channel blockers, digoxin or clonidine
        Detailed Inderal (Propranolol) risks & warnings »
        • Women of childbearing age
          • African descent
          • Current kidney problems
          • Medicine that increase potassium
          • Use of salt substitute
          Detailed Zestril (Lisinopril) risks & warnings »
          Pregnancy category
          PropranololLisinopril
          CFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          DFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          Alcohol
          No specific alcohol-related info.No specific alcohol-related info.
          Food
          No specific food-related info.No specific food-related info.
          Kidneys and liver
          No specific kidneys and liver-related info.
          • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
          • Requires routine blood tests to check kidney function.
          Sex
          No specific sex-related info.No specific sex-related info.
          Sleep
          No specific sleep-related info.No specific sleep-related info.
          Weight
          • Cases of heart failure due to taking Inderal (Propranolol) have been reported. Tell your doctor if you noticed increased swelling around your legs or ankles, sudden weight gain or sudden shortness of breath as these may be symptoms of heart failure.
          No specific weight-related info.
          Upsides and benefits
          PropranololLisinopril
          • A first-choice treatment to prevent chest pain (angina).
          • A first-choice treatment for heart failure, heart attack, heart valve disorders, and abnormal heart rhythm.
          • Also treats and prevents many non-heart problems, such as tremors, anxiety, migraines, and liver disease symptoms.
          • A first-choice blood pressure treatment for many people.
          • Lowers the risk of heart attack and stroke.
          • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
          • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
          Downsides and risks
          PropranololLisinopril
          • Taking a beta blocker might make you feel more tired or out of breath during exercise or normal daily routines. This gets better for most people, but for some might not go away.
          • Has more side effects than some beta blockers because it crosses into the brain and central nervous system.
          • Not a first-choice treatment for high blood pressure according to the latest guidelines, except if you have heart failure or heart disease. As a second choice, your doctor might add it to medicines you're already taking if your blood pressure is still too high.
          • Can hide symptoms of low blood sugar if you're diabetic.
          • You can't miss doses. Stopping Propranolol suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
          • Up to 1 in 10 people can get a dry cough with this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
          • Requires a yearly blood test to see how the medicine is affecting your body.
          • Not safe to use if you're pregnant.
          Tips from our pharmacists for people taking the medication
          PropranololLisinopril
          • Can cause insomnia and fatigue.
          • Can hide symptoms of low blood sugar. Be careful if you're diabetic.
          • Don't stop taking this medicine suddenly.
          • Can cause dizziness in the first few days.
          • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
          • Tell your doctor about any dizziness, fatigue, cough, or throat irritation that doesn't go away.
          • Requires routine blood tests to check kidney function.
          • Don't take it if you're pregnant.
          • Can cause dizziness in the first few days.
          • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
          Learn more
          More about PropranololSide effectsReviews & ratingsAlternativesFDA package insert
          More about LisinoprilSide effectsReviews & ratingsAlternativesFDA package insert