Compare Propranolol vs. Lisinopril

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Inderal (Propranolol)

Prescription only

Zestril (lisinopril)

Prescription only
Lowers blood pressure and controls heart rate.

Inderal (Propranolol) is good for treating many heart problems and other problems in the body, but it has more side effects than other beta blockers. You can't miss doses.

3.9/ 5 average rating with 61 reviewsforPropranolol
Lowers blood pressure.

Zestril (lisinopril) is a good blood pressure-lowering medicine that protects kidney function.

3.8/ 5 average rating with 687 reviewsforLisinopril
Upsides
  • A first-choice treatment to prevent chest pain (angina).
  • A first-choice treatment for heart failure, heart attack, heart valve disorders, and abnormal heart rhythm.
  • Also treats and prevents many non-heart problems, such as tremors, anxiety, migraines, and liver disease symptoms.
  • A first-choice blood pressure treatment for many people.
  • Lowers the risk of heart attack and stroke.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
  • Very cheap drug, and comes available as a liquid for children over 6 years of age.
Downsides
  • Taking a beta blocker might make you feel more tired or out of breath during exercise or normal daily routines. This gets better for most people, but for some might not go away.
  • Has more side effects than some beta blockers because it crosses into the brain and central nervous system.
  • Not a first-choice treatment for high blood pressure according to the latest guidelines, except if you have heart failure or heart disease. As a second choice, your doctor might add it to medicines you're already taking if your blood pressure is still too high.
  • Can hide symptoms of low blood sugar if you're diabetic.
  • You can't miss doses. Stopping Propranolol suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
  • Up to 10% of people can get a dry cough while using this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
  • Requires a yearly blood test to see how the medicine is affecting your body.
  • Zestril (lisinopril) isn't safe to use if you're pregnant.
  • Doesn't work as well in people of African descent, and can cause a greater chance of face, tongue, or lip swelling.
Used for
Dosage forms
  • Pill
  • Extended release
  • Liquid
  • Pill
  • Liquid
Price
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Reviews
61 reviews so far
66%
saidit'sworth it
62%
saiditworked well
15%
saidit'sa big hassle

Have you used Inderal (Propranolol)?

Leave a review
687 reviews so far
61%
saidit'sworth it
51%
saiditworked well
14%
saidit'sa big hassle

Have you used Zestril (lisinopril)?

Leave a review
Side effects
3possible side effects
  • Dizziness
    7%
  • Fatigue
    5%
  • Constipation
    3%
See more detailed side effects
1possible side effects
  • Low blood pressure
    5%
See more detailed side effects
Risks and risk factors
  • Increased chest pain or risk of heart attack
    • Suddenly stopping Inderal (Propranolol)
  • Heart failure
  • Increased risks during surgery
    • Major surgery requiring anesthesia
  • Masked symptoms of low blood sugar
    • Diabetes
  • Masked symptoms of overactive thyroid
  • Low blood pressure
    • Concurrent use of non-dihydropyridine calcium channel blockers, digoxin or clonidine
  • Serious skin reactions
See more detailed risks and warnings
  • Harm to fetus
    • Women of childbearing age
  • Cough
  • Swelling of face and head
    • African descent
  • High potassium
    • Current kidney problems
    • Medicines that increase potassium
    • Use of salt substitutes
  • Worsening kidney problems
    • History of kidney problems
  • Low blood pressure
    • Taking with alcohol
    • Taking other medicines that lower your blood pressure
See more detailed risks and warnings