Compare Propranolol vs. Lopressor

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Inderal
(Propranolol)

Lopressor
(Metoprolol Tartrate)

Lowers blood pressure and controls heart rate. Inderal (Propranolol) is good for treating many heart problems and other problems in the body, but it has more side effects than other beta blockers. You can't miss doses.Lowers blood pressure and controls heart rate. Lopressor (Metoprolol Tartrate) is good for controlling chest pain and treating heart failure and heart attack. You have to take it with food, and you can't miss doses.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.264150943396227Propranolol
Reviews for Inderal (Propranolol)
62%
of people say Inderal (Propranolol) is worth it
58%
say it works well
17%
say it's a big hassle
Reviews for Lopressor (Metoprolol Tartrate)
61%
1% vs. Inderal (Propranolol)
46%
12% vs. Inderal (Propranolol)
15%
+2% vs. Inderal (Propranolol)
Side effects
PropranololLopressor
  • Dizziness 5%
  • Fatigue 4%
More Propranolol side effects »
  • Abnormally slow heartbeat 9%
  • Low blood pressure 4%
  • First-degree heart block 3%
More Lopressor side effects »
How it works
PropranololLopressor
Inderal (Propranolol) is an alpha and beta blocker. It lowers blood pressure by slowing heart rate, relaxing blood vessels, and lowering the body's fight-or-flight response.Lopressor (Metoprolol Tartrate) is a beta blocker. It lowers blood pressure by slowing heart rate, relaxing blood vessels, and lowering the body's fight-or-flight response.
Type of medication
PropranololLopressor
Antihypertensive
Beta blocker
Prescription only
Antihypertensive
Beta blocker
Prescription only
Available as
PropranololLopressor
  • Pill
  • Extended release
  • Liquid
  • Pill
Used for (click to learn more)
PropranololLopressor
Risk factors for serious side effects
PropranololLopressor
  • Suddenly stopping Inderal (Propranolol)
    • Major surgery requiring anesthesia
    • Diabetes
      • Concurrent use of non-dihydropyridine calcium channel blockers, digoxin or clonidine
        Detailed Inderal (Propranolol) risks & warnings »
        • Diabetes
          • Coronary artery disease
          • Heart failure
          • Major surgery requiring anesthesia
          • History of asthma
          Detailed Lopressor (Metoprolol Tartrate) risks & warnings »
          Pregnancy category
          PropranololLopressor
          CFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          CFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          Alcohol
          No specific alcohol-related info.No specific alcohol-related info.
          Food
          No specific food-related info.
          • Metoprolol tartrate is the immediate release version of Toprol XL. You have to take Metoprolol tartrate with food for it to work best. (On the other hand, you can take Toprol XL any time.)
          • Take it with food.
          Kidneys and liver
          No specific kidneys and liver-related info.No specific kidneys and liver-related info.
          Sex
          No specific sex-related info.No specific sex-related info.
          Sleep
          No specific sleep-related info.No specific sleep-related info.
          Weight
          • Cases of heart failure due to taking Inderal (Propranolol) have been reported. Tell your doctor if you noticed increased swelling around your legs or ankles, sudden weight gain or sudden shortness of breath as these may be symptoms of heart failure.
          No specific weight-related info.
          Upsides and benefits
          PropranololLopressor
          • A first-choice treatment to prevent chest pain (angina).
          • A first-choice treatment for heart failure, heart attack, heart valve disorders, and abnormal heart rhythm.
          • Also treats and prevents many non-heart problems, such as tremors, anxiety, migraines, and liver disease symptoms.
          • A first-choice treatment to prevent chest pain (angina). Makes pain attacks less frequent and makes it easier to be active without having chest pain.
          • A first-choice treatment for heart failure. May prevent long-term heart damage.
          • A first-choice treatment for heart attack. Lowers the risk of death during and after a heart attack.
          Downsides and risks
          PropranololLopressor
          • Has more side effects than some beta blockers because it crosses into the brain and central nervous system.
          • You can't miss doses. Stopping Propranolol suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
          • Taking a beta blocker might make you feel more tired or out of breath during exercise or normal daily routines. This gets better for most people, but for some might not go away.
          • Not a first-choice treatment for high blood pressure according to the latest guidelines, except if you have heart failure or heart disease. As a second choice, your doctor might add it to medicines you're already taking if your blood pressure is still too high.
          • Can hide symptoms of low blood sugar if you're diabetic.
          • Metoprolol tartrate is the immediate release version of Toprol XL. You have to take Metoprolol tartrate with food for it to work best. (On the other hand, you can take Toprol XL any time.)
          • You can't miss doses. Stopping Metoprolol tartrate suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
          • Taking a beta blocker might make you feel more tired or out of breath during exercise or normal daily routines. This gets better for most people, but for some might not go away.
          • Not a first-choice treatment for high blood pressure according to the latest guidelines, except if you have heart failure or heart disease. As a second choice, your doctor might add it to medicines you're already taking if your blood pressure is still too high.
          • Can hide symptoms of low blood sugar if you're diabetic.
          Tips from our pharmacists for people taking the medication
          PropranololLopressor
          • Can cause insomnia and fatigue.
          • Can cause dizziness in the first few days.
          • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
          • Can hide symptoms of low blood sugar. Be careful if you're diabetic.
          • Don't stop taking this medicine suddenly.
          • Take it with food.
          • Can cause fatigue and headache.
          • This is the immediate release version. It also comes as an extended release form: Toprol XL (metoprolol succinate).
          • Can cause dizziness in the first few days.
          • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
          • Can hide symptoms of low blood sugar. Be careful if you're diabetic.
          • Don't stop taking this medicine suddenly.
          Learn more
          More about PropranololSide effectsReviews & ratingsAlternativesFDA package insert
          More about LopressorSide effectsReviews & ratingsAlternativesFDA package insert