Compare Propranolol vs. Toprol XL

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Inderal
(Propranolol)

Toprol Xl
(Metoprolol Succinate)

Lowers blood pressure and controls heart rate. Inderal (Propranolol) is good for treating many heart problems and other problems in the body, but it has more side effects than other beta blockers. You can't miss doses.Lowers blood pressure and controls heart rate. Toprol Xl (Metoprolol Succinate) is good for controlling chest pain and treating heart failure and heart attack. You can't miss doses.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.264150943396227Propranolol
Reviews for Inderal (Propranolol)
62%
of people say Inderal (Propranolol) is worth it
58%
say it works well
17%
say it's a big hassle
Reviews for Toprol Xl (Metoprolol Succinate)
60%
2% vs. Inderal (Propranolol)
55%
3% vs. Inderal (Propranolol)
13%
+4% vs. Inderal (Propranolol)
Side effects
PropranololToprol XL
  • Dizziness 5%
  • Fatigue 4%
More Propranolol side effects »
  • Abnormally slow heartbeat 9%
  • Low blood pressure 4%
  • Heart block 3%
More Toprol XL side effects »
How it works
PropranololToprol XL
Inderal (Propranolol) is an alpha and beta blocker. It lowers blood pressure by slowing heart rate, relaxing blood vessels, and lowering the body's fight-or-flight response.Toprol Xl (Metoprolol Succinate) is a beta blocker. It lowers blood pressure by slowing heart rate, relaxing blood vessels, and lowering the body's fight-or-flight response.
Type of medication
PropranololToprol XL
Antihypertensive
Beta blocker
Prescription only
Antihypertensive
Beta blocker
Prescription only
Available as
PropranololToprol XL
  • Pill
  • Extended release
  • Liquid
  • Pill
  • Extended release
Used for (click to learn more)
PropranololToprol XL
Risk factors for serious side effects
PropranololToprol XL
  • Suddenly stopping Inderal (Propranolol)
    • Major surgery requiring anesthesia
    • Diabetes
      • Concurrent use of non-dihydropyridine calcium channel blockers, digoxin or clonidine
        Detailed Inderal (Propranolol) risks & warnings »
        • Diabetes
          • Coronary artery disease
          • Heart failure
          • Major surgery requiring anesthesia
          • History of asthma
          Detailed Toprol Xl (Metoprolol Succinate) risks & warnings »
          Pregnancy category
          PropranololToprol XL
          CFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          CFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          Alcohol
          No specific alcohol-related info.No specific alcohol-related info.
          Food
          No specific food-related info.No specific food-related info.
          Kidneys and liver
          No specific kidneys and liver-related info.No specific kidneys and liver-related info.
          Sex
          No specific sex-related info.No specific sex-related info.
          Sleep
          No specific sleep-related info.No specific sleep-related info.
          Weight
          • Cases of heart failure due to taking Inderal (Propranolol) have been reported. Tell your doctor if you noticed increased swelling around your legs or ankles, sudden weight gain or sudden shortness of breath as these may be symptoms of heart failure.
          No specific weight-related info.
          Upsides and benefits
          PropranololToprol XL
          • A first-choice treatment to prevent chest pain (angina).
          • A first-choice treatment for heart failure, heart attack, heart valve disorders, and abnormal heart rhythm.
          • Also treats and prevents many non-heart problems, such as tremors, anxiety, migraines, and liver disease symptoms.
          • A first-choice treatment to prevent chest pain (angina). Makes pain attacks less frequent and makes it easier to be active without having chest pain.
          • A first-choice treatment for heart failure. May prevent long-term heart damage.
          • A first-choice treatment for heart attack. Lowers the risk of death during and after a heart attack.
          • Toprol XL is the extended release version of Lopressor.
          Downsides and risks
          PropranololToprol XL
          • Has more side effects than some beta blockers because it crosses into the brain and central nervous system.
          • Not a first-choice treatment for high blood pressure according to the latest guidelines, except if you have heart failure or heart disease. As a second choice, your doctor might add it to medicines you're already taking if your blood pressure is still too high.
          • You can't miss doses. Stopping Propranolol suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
          • Taking a beta blocker might make you feel more tired or out of breath during exercise or normal daily routines. This gets better for most people, but for some might not go away.
          • Can hide symptoms of low blood sugar if you're diabetic.
          • Not a first-choice treatment for high blood pressure according to the latest guidelines, except if you have heart failure or heart disease.
          • You can't miss doses. Stopping Toprol XL suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
          • Taking a beta blocker might make you feel more tired or out of breath during exercise or normal daily routines. This gets better for most people, but for some might not go away.
          • Can hide symptoms of low blood sugar if you're diabetic.
          Tips from our pharmacists for people taking the medication
          PropranololToprol XL
          • Can cause insomnia and fatigue.
          • Can cause dizziness in the first few days.
          • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
          • Can hide symptoms of low blood sugar. Be careful if you're diabetic.
          • Don't stop taking this medicine suddenly.
          • Can cause fatigue and headache.
          • Extended release version. Also comes in immediate release called Lopressor (metoprolol tartrate).
          • Can cause dizziness in the first few days.
          • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
          • Can hide symptoms of low blood sugar. Be careful if you're diabetic.
          • Don't stop taking this medicine suddenly.
          Learn more
          More about PropranololSide effectsReviews & ratingsAlternativesFDA package insert
          More about Toprol XLSide effectsReviews & ratingsAlternativesFDA package insert