Compare Propranolol vs. Toprol XL

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Inderal
(Propranolol)

Toprol Xl
(Metoprolol Succinate)

Lowers blood pressure and controls heart rate. Inderal (Propranolol) is good for treating many heart problems and other problems in the body, but it has more side effects than other beta blockers. You can't miss doses.Lowers blood pressure and controls heart rate. Toprol Xl (Metoprolol Succinate) is good for controlling chest pain and treating heart failure and heart attack. You can't miss doses.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.39Propranolol
Reviews for Inderal (Propranolol)
66%
of people (All ages) say Inderal (Propranolol) is worth it
62%
say it works well
15%
say it's a big hassle
Have you used Inderal (Propranolol)?
Worth itNot sureNot worth it
Reviews for Toprol Xl (Metoprolol Succinate)
60%
-6% worse vs. Inderal (Propranolol)
54%
-8% worse vs. Inderal (Propranolol)
13%
+2% better vs. Inderal (Propranolol)
164 reviews
Have you used Toprol Xl (Metoprolol Succinate)?
Worth itNot sureNot worth it
Side effects
PropranololToprol XL
  • Dizziness 5%
  • Fatigue 2%
  • Constipation 3%
More Propranolol side effects »
  • Tiredness 10%
  • Dizziness 10%
  • Low mood disorder 5%
  • Diarrhea 5%
  • Rash or pruritus 5%
  • Shortness of breath 3%
  • Abnormally slow heartbeat 3%
  • Low blood pressure 4%
  • Heart block 3%
More Toprol XL side effects »
How it works
PropranololToprol XL
Inderal (Propranolol) is an alpha and beta blocker. It lowers blood pressure by slowing heart rate, relaxing blood vessels, and lowering the body's fight-or-flight response.Toprol Xl (Metoprolol Succinate) is a beta blocker. It lowers blood pressure by slowing heart rate, relaxing blood vessels, and lowering the body's fight-or-flight response.
Type of medication
PropranololToprol XL
Prescription only
Prescription only
Available as
PropranololToprol XL
  • Pill
  • Extended release
  • Liquid
  • Pill
  • Extended release
Used for
PropranololToprol XL
Risk factors for serious side effects
PropranololToprol XL
  • Suddenly stopping Inderal (Propranolol)
    • Major surgery requiring anesthesia
    • Diabetes
      • Concurrent use of non-dihydropyridine calcium channel blockers, digoxin or clonidine
        Detailed Inderal (Propranolol) risks & warnings »
        • Diabetes
          • Coronary artery disease
          • Heart failure
          • Major surgery requiring anesthesia
          • History of asthma
          Detailed Toprol Xl (Metoprolol Succinate) risks & warnings »
          Pregnancy

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          Upsides and benefits
          PropranololToprol XL
          • A first-choice treatment to prevent chest pain (angina).
          • A first-choice treatment for heart failure, heart attack, heart valve disorders, and abnormal heart rhythm.
          • Also treats and prevents many non-heart problems, such as tremors, anxiety, migraines, and liver disease symptoms.
          • A first-choice treatment to prevent chest pain (angina). Makes pain attacks less frequent and makes it easier to be active without having chest pain.
          • A first-choice treatment for heart failure. May prevent long-term heart damage.
          • A first-choice treatment for heart attack. Lowers the risk of death during and after a heart attack.
          • Toprol XL is the extended release version of Lopressor.
          Downsides and risks
          PropranololToprol XL
          • Taking a beta blocker might make you feel more tired or out of breath during exercise or normal daily routines. This gets better for most people, but for some might not go away.
          • Has more side effects than some beta blockers because it crosses into the brain and central nervous system.
          • Not a first-choice treatment for high blood pressure according to the latest guidelines, except if you have heart failure or heart disease. As a second choice, your doctor might add it to medicines you're already taking if your blood pressure is still too high.
          • Can hide symptoms of low blood sugar if you're diabetic.
          • You can't miss doses. Stopping Propranolol suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
          • Taking a beta blocker might make you feel more tired or out of breath during exercise or normal daily routines. This gets better for most people, but for some might not go away.
          • Not a first-choice treatment for high blood pressure according to the latest guidelines, except if you have heart failure or heart disease.
          • Can hide symptoms of low blood sugar if you're diabetic.
          • You can't miss doses. Stopping Toprol XL suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
          Tips from our pharmacists for people taking the medication
          PropranololToprol XL
          • Can cause dizziness in the first few days.
          • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
          • Can cause insomnia and fatigue.
          • Can hide symptoms of low blood sugar. Be careful if you're diabetic.
          • Don't stop taking this medicine suddenly.
          • Can cause dizziness in the first few days.
          • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
          • Can cause fatigue and headache.
          • Can hide symptoms of low blood sugar. Be careful if you're diabetic.
          • Don't stop taking this medicine suddenly.
          • Extended release version. Also comes in immediate release called Lopressor (metoprolol tartrate).
          Learn more
          More about PropranololSide effectsReviews & ratingsAlternativesFDA package insert
          Have you used Inderal (Propranolol)?
          Worth itNot sureNot worth it
          More about Toprol XLSide effectsReviews & ratingsAlternativesFDA package insert
          Have you used Toprol Xl (Metoprolol Succinate)?
          Worth itNot sureNot worth it