Compare Estazolam vs. chlordiazepoxide / amitriptyline

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Prosom
(estazolam)

Limbitrol
(chlordiazepoxide / amitriptyline)

Helps you stay asleep longer. Prosom (estazolam) can help you sleep, but you might feel hungover the next day.Treats anxiety and depression. While Limbitrol (chlordiazepoxide / amitriptyline) as a combination can be used to treat both anxiety and depression, other medicines are considered first choice because chlordiazepoxide can be potentially addicting.
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Prices and coupon for 30 (2mg) tablets of estazolam
Coupons for
Prices and coupon for 60 (5mg/12.5mg) tablets of chlordiazepoxide / amitriptyline
Reviews & ratings
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Have you used Prosom (estazolam)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Limbitrol (chlordiazepoxide / amitriptyline)?
Worth itNot sureNot worth it
Side effects
Estazolamchlordiazepoxide / amitriptyline
  • Sleepiness 15%
  • Weakness 3%
  • Difficulty controlling muscles 4%
  • Dizziness 4%
  • Abnormal coordination 3%
  • Leg and foot pain 1%
More Estazolam side effects »

The chlordiazepoxide / amitriptyline FDA package insert doesn’t have numbers about how common side effects are.

More about chlordiazepoxide / amitriptyline side effects »
How it works
Estazolamchlordiazepoxide / amitriptyline
Prosom (estazolam) is a benzodiazepine. It helps you stay asleep by improving the quality of your sleep so you don't wake up as much at night.Limbitrol (chlordiazepoxide / amitriptyline) is a combination of 2 medicines. Chlordiazepoxide is a benzodiazepine, and it calms activity in a part of the brain responsible for emotional responses. Amitriptyline is a tricyclic antidepressant, and it raises the amount of norepinephrine and serotonin in the brain, which can improve mood.
Type of medication
Estazolamchlordiazepoxide / amitriptyline
Prescription only
Prescription only
Available as
Estazolamchlordiazepoxide / amitriptyline
  • Pill
  • Pill
Used for
Estazolamchlordiazepoxide / amitriptyline
  • Anxiety And Depression
Risk factors for serious side effects
Estazolamchlordiazepoxide / amitriptyline
  • Using Prosom (estazolam) for more than 10 days
  • Drinking alcohol
  • Taking sedative medicines
  • People age 65 or older
    Detailed Prosom (estazolam) risks & warnings »
    • People under age 24
        • Glaucoma
        • Heart disease
        • Drinking alcohol or taking narcotics
        Detailed Limbitrol (chlordiazepoxide / amitriptyline) risks & warnings »
        Pregnancy

        Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Alcohol
        Estazolamchlordiazepoxide / amitriptyline
        • Don't drink alcohol or take other narcotics with Prosom (estazolam) because it can slow your breathing.
        • Don't drink alcohol or take any narcotics while taking Limbitrol (chlordiazepoxide / amitriptyline) since it can slow your breathing.
        • Don't drink alcohol or take narcotics, tranquilizers, or antihistamines if you're taking Limbitrol (chlordiazepoxide / amitriptyline). This can slow down your breathing. Talk to your doctor if this is a problem.
        Sleep
        Estazolamchlordiazepoxide / amitriptyline
        No sleep related info.
        • Limbitrol (chlordiazepoxide / amitriptyline) can make you sleepy and unable to focus, so don't drive or do anything requiring concentration for a few hours after taking it until you know how it affects you. This can be worse if you drink alcohol or take narcotics.
        Upsides and benefits
        Estazolamchlordiazepoxide / amitriptyline
        • Prosom (estazolam) is available in generic.
        • Limbitrol (chlordiazepoxide / amitriptyline) is available as a generic.
        • Limbitrol (chlordiazepoxide / amitriptyline) works faster than amitriptyline alone.
        Downsides and risks
        Estazolamchlordiazepoxide / amitriptyline
        • Prosom (estazolam) isn't recommended if you're age 65 or older because the side effects can be more intense.
        • You can become dependent on Prosom (estazolam) if you take it for more than a few weeks.
        • If you stop Prosom (estazolam) suddenly after taking it for a while, your insomnia might come back even worse than when you started.
        • Limbitrol (chlordiazepoxide / amitriptyline) is only available in certain strengths, so it can be difficult to customize a dose that treats both anxiety and depression.
        • Limbitrol (chlordiazepoxide / amitriptyline) contains chlordiazepoxide, which can be potentially addicting.
        • You might not notice any changes in your mood until you've been taking Limbitrol (chlordiazepoxide / amitriptyline) for several weeks.
        • Amitriptyline alone is considered a better treatment for anxiety and depression than Limbitrol (chlordiazepoxide / amitriptyline).
        • Other medicines are considered first choice for treating anxiety and depression over Limbitrol (chlordiazepoxide / amitriptyline).
        Tips from our pharmacists for people taking the medication
        Estazolamchlordiazepoxide / amitriptyline
        • Don't take Prosom (estazolam) unless you know you'll be going to sleep right away.
        • Make sure you can sleep for at least 8 hours before you take it.
        • Prosom (estazolam) works best if you develop good sleeping habits.
        • Take Prosom (estazolam) for the shortest amount of time needed to treat your insomnia since it can be addicting.
        • Don't drink alcohol or take other narcotics with Prosom (estazolam) because it can slow your breathing.
        • Don't drink alcohol or take any narcotics while taking Limbitrol (chlordiazepoxide / amitriptyline) since it can slow your breathing.
        • If you've taken Limbitrol (chlordiazepoxide / amitriptyline) for an extended amount of time, don't stop taking it suddenly without talking to your doctor first. It can be very dangerous.
        • Don't drive or do anything requiring concentration while taking Limbitrol (chlordiazepoxide / amitriptyline) since it can make you sleepy. This can be worse if you drink alcohol or take narcotics.
        • You might not notice changes in your mood until you've taken Limbitrol (chlordiazepoxide / amitriptyline) for at least a few weeks.
        • If you're being switched to Limbitrol (chlordiazepoxide / amitriptyline) from a group of medicines called monoamine oxidase inhibitors (MAOI), you should wait at least 14 days before you start.
        Learn more
        More about EstazolamSide effectsAlternativesFDA package insert
        Have you used Prosom (estazolam)?
        Worth itNot sureNot worth it
        More about chlordiazepoxide / amitriptylineSide effectsAlternativesFDA package insert
        Have you used Limbitrol (chlordiazepoxide / amitriptyline)?
        Worth itNot sureNot worth it