Compare Estazolam vs. desipramine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Prosom (estazolam)

Prescription only

Norpramin (desipramine)

Prescription only
Helps you stay asleep longer.

Prosom (estazolam) can help you sleep, but you might feel hungover the next day.

Stabilizes your mood.

Norpramin (desipramine) is not a first choice for treating depression because of its effects on the heart, but it can be good if other medicines haven't worked.

Upsides
  • Prosom (estazolam) is available in generic.
  • Norpramin (desipramine) is available in generic and in many different strengths, so the dose can be more customized.
  • Norpramin (desipramine) has fewer side effects than similar tricyclic antidepressants.
Downsides
  • Prosom (estazolam) isn't recommended if you're age 65 or older because the side effects can be more intense.
  • You can become dependent on Prosom (estazolam) if you take it for more than a few weeks.
  • If you stop Prosom (estazolam) suddenly after taking it for a while, your insomnia might come back even worse than when you started.
  • Norpramin (desipramine) isn't recommended if you or your family has heart disease, seizures, or glaucoma.
  • Norpramin (desipramine) isn't a first choice for depression because it has more side effects than other antidepressants.
  • In some people, Norpramin (desipramine) can make you sleepy. In other people, Norpramin (desipramine) can keep you awake.
  • If you have diabetes, Norpramin (desipramine) can make your blood sugar go up.
  • Not recommended in children under 12 years of age.
Used for
Dosage forms
  • Pill
  • Pill
Price
No pricing information available
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Reviews
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Side effects
19possible side effects
  • Sleepiness
    42%
  • Headache
    16%
  • Weakness
    11%
  • Difficulty controlling muscles
    8%
  • Nervousness
    8%
  • Dizziness
    7%
  • Uneasiness
    5%
  • Nausea
    4%
  • Abnormal coordination
    4%
  • Leg and foot pain
    3%
  • Hangover
    3%
  • Common cold symptoms
    3%
  • Back pain
    2%
  • Body pain
    2%
  • Indigestion
    2%
  • Confusion
    2%
  • Depression
    2%
  • Abnormal dreams
    2%
  • Abnormal thoughts
    2%
See more detailed side effects
The Norpramin (desipramine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Tolerance and addiction
    • Using Prosom (estazolam) for more than 10 days
  • Behavior changes
    • Drinking alcohol
    • Taking sedative medicines
  • Hangover effect
    • People age 65 or older
  • Allergic reactions
See more detailed risks and warnings
  • Higher risk of suicide
    • People under age 24
  • Possible bipolar disorder
  • Serotonin syndrome
    • Tricyclic antidepressants
    • Fentanyl
    • Tramadol
    • Buspirone
    • ADHD medicines
    • Triptans
  • Changes to the heartbeat
    • History of heart disease
  • Higher risk for seizures
    • History of seizures
    • History of brain damage or alcohol withdrawal
See more detailed risks and warnings