Compare Estazolam vs. desipramine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Prosom
(estazolam)

Norpramin
(desipramine)

Helps you stay asleep longer. Prosom (estazolam) can help you sleep, but you might feel hungover the next day.Stabilizes your mood. Norpramin (desipramine) is not a first choice for treating depression because of its effects on the heart, but it can be good if other medicines haven't worked.
Reviews & ratings
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Have you used Prosom (estazolam)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Norpramin (desipramine)?
Worth itNot sureNot worth it
Side effects
Estazolamdesipramine
  • Sleepiness 15%
  • Weakness 3%
  • Difficulty controlling muscles 4%
  • Dizziness 4%
  • Abnormal coordination 3%
  • Leg and foot pain 1%
More Estazolam side effects »

The desipramine FDA package insert doesn’t have numbers about how common side effects are.

More about desipramine side effects »
How it works
Estazolamdesipramine
Prosom (estazolam) is a benzodiazepine. It helps you stay asleep by improving the quality of your sleep so you don't wake up as much at night.Norpramin (desipramine) is a tricyclic antidepressant. It increases the amount of norepinephrine and serotonin in the brain, two chemicals that regulate mood.
Type of medication
Estazolamdesipramine
Prescription onlyPrescription only
Available as
Estazolamdesipramine
  • Pill
  • Pill
Used for
Estazolamdesipramine
Risk factors for serious side effects
Estazolamdesipramine
  • Using Prosom (estazolam) for more than 10 days
  • Drinking alcohol
  • Taking sedative medicines
  • People age 65 or older
Detailed Prosom (estazolam) risks & warnings »
  • People under age 24
  • Tricyclic antidepressants
  • Fentanyl
  • Tramadol
  • Buspirone
Detailed Norpramin (desipramine) risks & warnings »
Pregnancy

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Alcohol
Estazolamdesipramine
  • Don't drink alcohol or take other narcotics with Prosom (estazolam) because it can slow your breathing.
No alcohol related info.
Upsides and benefits
Estazolamdesipramine
  • Prosom (estazolam) is available in generic.
  • Norpramin (desipramine) is available in generic and in many different strengths, so the dose can be more customized.
  • Norpramin (desipramine) has fewer side effects than similar tricyclic antidepressants.
Downsides and risks
Estazolamdesipramine
  • Prosom (estazolam) isn't recommended if you're age 65 or older because the side effects can be more intense.
  • You can become dependent on Prosom (estazolam) if you take it for more than a few weeks.
  • If you stop Prosom (estazolam) suddenly after taking it for a while, your insomnia might come back even worse than when you started.
  • Norpramin (desipramine) isn't recommended if you or your family has heart disease, seizures, or glaucoma.
  • Norpramin (desipramine) isn't a first choice for depression because it has more side effects than other antidepressants.
  • In some people, Norpramin (desipramine) can make you sleepy. In other people, Norpramin (desipramine) can keep you awake.
  • If you have diabetes, Norpramin (desipramine) can make your blood sugar go up.
  • Not recommended in children under 12 years of age.
Tips from our pharmacists for people taking the medication
Estazolamdesipramine
  • Don't take Prosom (estazolam) unless you know you'll be going to sleep right away.
  • Make sure you can sleep for at least 8 hours before you take it.
  • Prosom (estazolam) works best if you develop good sleeping habits.
  • Take Prosom (estazolam) for the shortest amount of time needed to treat your insomnia since it can be addicting.
  • Don't drink alcohol or take other narcotics with Prosom (estazolam) because it can slow your breathing.
  • Don't drive or do anything requiring concentration until you know how Norpramin (desipramine) affects you since it can make you feel sleepy.
  • Talk to your doctor right away if your mood suddenly darkens and you want to hurt yourself while taking Norpramin (desipramine).
  • If you're being switched to Norpramin (desipramine) from monoamine oxidase inhibitors, you'll need to wait 2 weeks before you can start it.
  • Don't stop taking Norpramin (desipramine) suddenly without talking to your doctor first.
Learn more
More about EstazolamSide effectsAlternativesFDA package insert
Have you used Prosom (estazolam)?
Worth itNot sureNot worth it
More about desipramineSide effectsAlternativesFDA package insert
Have you used Norpramin (desipramine)?
Worth itNot sureNot worth it