Compare Provera vs. Alora

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Regulates your menstrual cycle and supplements estrogen treatments for menopause.

Provera (Medroxyprogesterone) works well to regulate your menstrual cycle and stop irregular bleeding. It also protects the uterus from estrogen's harmful effects.

Relieves hot flashes and vaginal dryness due to menopause and strengthens your bones.

Alora (estradiol patch) treats symptoms from low estrogen, and it may have fewer side effects than oral estrogen pills.

Upsides
  • Provera (Medroxyprogesterone) can be used to treat multiple hormone problems in women.
  • After menopause, taking estrogen raises your risk of uterine cancer. However, taking progesterone, like in Provera (Medroxyprogesterone), along with estrogen gives you the positive effects of estrogen, but also prevents it from damaging your uterus.
  • Women taking an estrogen/progestin combination medications have a lower risk of uterine cancer.
  • Alora (estradiol patch) replaces estrogen to your whole body and relieves many symptoms due to low estrogen, like hot flashes and vaginal dryness.
  • The patch is good for people who don't want to or can't take daily pills.
  • Can be worn while swimming, bathing, and showering.
  • By using a patch instead of a pill, there's a lower risk of side effects such as blood clots and stroke since lower amounts of estrogen are used in patches.
  • Lowers your risk of fractures by keeping your bones healthy.
Downsides
  • You can't take Provera (Medroxyprogesterone) if you've had a hysterectomy (your uterus removed). You also can't take it if you're pregnant or breastfeeding, have unusual vaginal bleeding, or have a history of blood clots, certain kinds of cancer, stroke, heart attack, liver problems, or bleeding problems.
  • You need to replace Alora (estradiol patch) twice a week, compared to other patches that are once a week.
  • Patches can fall off.
  • Increases your risk of uterine and breast cancer.
  • Increases your risk of developing blood clots and stroke.
  • Can worsen other health conditions, like high cholesterol, asthma, diabetes, fluid retention, and migraines.
  • Can't be used in people with liver problems.
Used for
  • Amenorrhea
  • Abnormal uterine bleeding
  • Prevention of uterine cancer in women taking estrogen
  • Endometriosis
  • Treats hot flashes, night sweats and flushing in women in menopause
  • Treats vaginal changes in women in menopause
  • Treats low estrogen in women
  • Prevents bone thinning in women in menopause
Dosage forms
  • Pill
  • Patch
Price
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Reviews
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Side effects
The Provera (Medroxyprogesterone) FDA package insert doesn’t have numbers about how common side effects are.
31possible side effects
  • Vaginal bleeding
    33%
  • Headache
    21%
  • Lung infection
    16%
  • Pain
    9%
  • Sinus infection
    8%
  • Vaginal inflammation
    8%
  • Breast pain
    7%
  • Back pain
    6%
  • Skin irritation
    6%
  • Accidental injury
    5%
  • Gas
    5%
  • Trouble sleeping
    5%
  • Itchiness
    5%
  • Nausea
    4%
  • Flu like symptoms
    3%
  • Stomach pain
    3%
  • Diarrhea
    3%
  • Depression
    3%
  • Airway inflammation
    3%
  • Cough
    3%
  • Rash
    3%
  • Weakness
    2%
  • Constipation
    2%
  • Swelling of arms and legs
    2%
  • Muscle aches
    2%
  • Anxiety
    2%
  • Sore throat
    2%
  • Breast growth
    2%
  • Bladder infection
    2%
  • White or yellow vaginal discharge
    2%
  • Breast tumor
    2%
See more detailed side effects
Risks and risk factors
  • Breast cancer
    • Personal or family history of breast cancer
  • Ovarian cancer
    • Family history of ovarian cancer
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Smoking
    • Obesity
    • Hypertension
    • Diabetes
    • High cholesterol
    • Systemic lupus erythematosus (SLE)
  • Depression
    • History of depression
  • Liver problems
    • History of liver problems
  • Harm to fetus
    • Women of childbearing age
See more detailed risks and warnings
  • Endometrial cancer
    • Using estrogen for more than one year
  • Breast cancer
    • Personal or family history of breast cancer
    • Using estrogen for more than one year
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Smoking
    • Obesity
    • Systemic lupus erythematosus (SLE)
  • Increased risk of heart disease
    • Smoking
    • Obesity
    • High blood pressure
    • High blood sugar
    • High cholesterol
    • Age 50 or older
  • Dementia
    • Age 65 or older
  • Pancreas swelling (pancreatitis)
    • High levels of triglycerides
See more detailed risks and warnings