Compare Provera vs. Climara

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Provera
(Medroxyprogesterone)

Climara
(Estradiol Patch)

Regulates your menstrual cycle and supplements estrogen treatments for menopause. Provera (Medroxyprogesterone) works well to regulate your menstrual cycle and stop irregular bleeding. It also protects the uterus from estrogen's harmful effects.Treats low estrogen, relieves menopause symptoms, and lowers your risk of osteoporosis. You only have to think about the Climara (Estradiol Patch) once a week, and it may have fewer side effects than oral estrogen pills.
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Reviews & ratings
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Have you used Provera (Medroxyprogesterone)?
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Have you used Climara (Estradiol Patch)?
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Side effects
ProveraClimara

We haven’t found good data for Provera side effects.

FDA side effect reports for Provera »
  • Breast pain 1%
  • Sinus inflammation 1%
  • Inflammation inside the nose 1%
  • Swelling due to excess fluid 7%
  • Abdominal pain 3%
  • Pain 1%
More Climara side effects »
How it works
ProveraClimara
Provera (Medroxyprogesterone) contains medroxyprogesterone, a progesterone hormone that works to balance hormone changes in the body. In premenopausal women, it prevents thickening of the uterus lining and regulates your menstrual cycle. It's also added to hormone therapy to protect the uterus from the harmful effects of estrogen.The Climara (Estradiol Patch) replaces an estrogen hormone, estradiol, that your body loses during and after menopause. Higher levels of estradiol relieve symptoms of low estrogen and menopause and prevent bone loss.
Type of medication
ProveraClimara
Prescription only
Prescription only
Available as
ProveraClimara
  • Pill
  • Patch
Used for
ProveraClimara
  • Amenorrhea
  • Hot Flashes And Night Sweats
Risk factors for serious side effects
ProveraClimara
  • Personal or family history of breast cancer
  • Family history of ovarian cancer
  • Personal or family history of blood clots
  • Smoking
  • Obesity
  • Hypertension
  • Diabetes
  • High cholesterol
  • Systemic lupus erythematosus (SLE)
  • History of depression
  • History of liver problems
  • Women of childbearing age
Detailed Provera (Medroxyprogesterone) risks & warnings »
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
  • Systemic lupus erythematosus (SLE)
  • Smoking
  • Obesity
  • High blood pressure
  • High blood sugar
  • High cholesterol
  • Age 50 or older
  • Women of childbearing age
  • High levels of triglycerides
Detailed Climara (Estradiol Patch) risks & warnings »
Pregnancy

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Weight
ProveraClimara
  • Can cause headache, weight gain, breast tenderness, or changes in mood.
  • Provera (Medroxyprogesterone) contains progestin. It could cause a higher risk of ovarian cancer, especially if you have a family history of it. Your doctor can help you weigh the risks versus the benefits of this medication.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
Upsides and benefits
ProveraClimara
  • Provera (Medroxyprogesterone) can be used to treat multiple hormone problems in women.
  • After menopause, taking estrogen raises your risk of uterine cancer. However, taking progesterone, like in Provera (Medroxyprogesterone), along with estrogen gives you the positive effects of estrogen, but also prevents it from damaging your uterus.
  • Women taking an estrogen/progestin combination medications have a lower risk of uterine cancer.
  • The Climara (Estradiol Patch) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen, like hot flashes and vaginal dryness.
  • The patch is good for people who don't want to take daily pills.
  • Can be worn while swimming, bathing, and showering.
  • By using a patch instead of a pill, there's a lower risk of side effects such as blood clots and stroke since lower amounts of estrogen are used in patches.
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
  • Improves mood, energy, and mental alertness for some people.
Downsides and risks
ProveraClimara
  • You can't take Provera (Medroxyprogesterone) if you've had a hysterectomy (your uterus removed). You also can't take it if you're pregnant or breastfeeding, have unusual vaginal bleeding, or have a history of blood clots, certain kinds of cancer, stroke, heart attack, liver problems, or bleeding problems.
  • Patch can fall off.
  • Increases your risk of uterine and breast cancer.
  • If you have your uterus, you have to use the Climara (Estradiol Patch) with another hormone called progestin to lower your risk of uterine cancer.
  • Increases your risk of developing blood clots and stroke.
  • Can worsen other health conditions, like high cholesterol, asthma, diabetes, fluid retention, and migraines.
  • Can't be used in people with liver problems.
Tips from our pharmacists for people taking the medication
ProveraClimara
  • The dose of Provera (Medroxyprogesterone) will be different depending on what you’re using it for, so take it exactly the way your doctor tells you.
  • Talk to your doctor every few months about using the lowest possible dose of Provera (Medroxyprogesterone). Since there can be a lot of long-term side effects, take it only as long as you need it.
  • Can cause headache, weight gain, breast tenderness, or changes in mood.
  • If you're taking Provera (Medroxyprogesterone) to regulate your period, you'll get withdrawal bleeding 3 to 7 days after stopping Provera (Medroxyprogesterone).
  • Remove the patch by tearing the package by hand and not with scissors. Never cut the patch.
  • Apply the sticky side of the patch to clean, dry, hairless skin below your waistline on areas as instructed by the manufacturer (never on your breast).
  • Replace the patch every 7 days on a different area of your skin to lower your risk of skin irritation.
  • Fold together the sticky sides of used patches before throwing them away to avoid exposing others to the medicine. Don't flush them down the toilet.
  • Shouldn't be used forever. Talk to your doctor regularly to see if you still need treatment.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Tell your doctor about any unusual vaginal bleeding.
  • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
Learn more
More about ProveraSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Provera (Medroxyprogesterone)?
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More about ClimaraSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Climara (Estradiol Patch)?
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