Compare Provera vs. Combipatch

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Provera
(medroxyprogesterone)

Combipatch
(estradiol / norethindrone patch)

Regulates your menstrual cycle and supplements estrogen treatments for menopause. Provera (Medroxyprogesterone) works well to regulate your menstrual cycle and stop irregular bleeding. It also protects the uterus from estrogen's harmful effects.Treats low estrogen and relieves menopause symptoms. Combipatch (estradiol / norethindrone patch) is a twice weekly patch that effectively treats menopause and causes less blood clots or stroke than combination pills.
Reviews & ratings
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Have you used Provera (medroxyprogesterone)?
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Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Combipatch (estradiol / norethindrone patch)?
Worth itNot sureNot worth it
Side effects
ProveraCombipatch

We haven’t found good data for Provera side effects.

FDA side effect reports for Provera »
  • Breast pain 18%
  • Menstrual cramps 15%
  • Back pain 6%
  • Nausea 4%
  • Flu like symptoms 2%
  • Abnormal pap smear 3%
  • Weakness 4%
  • Stomach pain 3%
More Combipatch side effects »
How it works
ProveraCombipatch
Provera (Medroxyprogesterone) contains medroxyprogesterone, a progesterone hormone that works to balance hormone changes in the body. In premenopausal women, it prevents thickening of the uterus lining and regulates your menstrual cycle. It's also added to hormone therapy to protect the uterus from the harmful effects of estrogen.Combipatch (estradiol / norethindrone patch) is a combination patch that works to balance hormone changes in your body during and after menopause. Estradiol (an estrogen) reduces hot flashes and night sweats. Norethindrone (a progestin) protects the uterus from damage.
Type of medication
ProveraCombipatch
Prescription onlyPrescription only
Available as
ProveraCombipatch
  • Pill
  • Patch
Used for
ProveraCombipatch
  • Amenorrhea
Risk factors for serious side effects
ProveraCombipatch
  • Personal or family history of breast cancer
  • Family history of ovarian cancer
  • Personal or family history of blood clots
  • Smoking
  • Obesity
Detailed Provera (medroxyprogesterone) risks & warnings »
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Personal or family history of blood clots
  • Smoking
Detailed Combipatch (estradiol / norethindrone patch) risks & warnings »
Pregnancy

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Weight
ProveraCombipatch
  • Provera (Medroxyprogesterone) contains progestin. It could cause a higher risk of ovarian cancer, especially if you have a family history of it. Your doctor can help you weigh the risks versus the benefits of this medication.
  • Can cause headache, weight gain, breast tenderness, or changes in mood.
No weight related info.
Upsides and benefits
ProveraCombipatch
  • Provera (Medroxyprogesterone) can be used to treat multiple hormone problems in women.
  • After menopause, taking estrogen raises your risk of uterine cancer. However, taking progesterone, like in Provera (Medroxyprogesterone), along with estrogen gives you the positive effects of estrogen, but also prevents it from damaging your uterus.
  • Women taking an estrogen/progestin combination medications have a lower risk of uterine cancer.
  • Twice weekly patch. Good for people who don't want to take daily pills.
  • Replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, vaginal dryness).
  • Less likely to cause blood clots or stroke than pills since patches contain a lower amount of hormones.
  • Good for women with an intact uterus.
  • You can bathe, shower, and swim while wearing the patch, as long as you don't rub the patch.
Downsides and risks
ProveraCombipatch
  • You can't take Provera (Medroxyprogesterone) if you've had a hysterectomy (your uterus removed). You also can't take it if you're pregnant or breastfeeding, have unusual vaginal bleeding, or have a history of blood clots, certain kinds of cancer, stroke, heart attack, liver problems, or bleeding problems.
  • More potential side effects than single ingredient medications since it exposes your whole body to two hormones.
  • You may get irregular bleeding and spotting that can last a few months to a year.
  • The patch can't be exposed to direct sunlight for long periods of time.
  • Can be expensive since it's only available as a brand name product.
Tips from our pharmacists for people taking the medication
ProveraCombipatch
  • The dose of Provera (Medroxyprogesterone) will be different depending on what you’re using it for, so take it exactly the way your doctor tells you.
  • Talk to your doctor every few months about using the lowest possible dose of Provera (Medroxyprogesterone). Since there can be a lot of long-term side effects, take it only as long as you need it.
  • Can cause headache, weight gain, breast tenderness, or changes in mood.
  • If you're taking Provera (Medroxyprogesterone) to regulate your period, you'll get withdrawal bleeding 3 to 7 days after stopping Provera (Medroxyprogesterone).
  • Remove the patch by tearing the package by hand and not with scissors. Never cut the patch.
  • Apply the sticky side of the patch to clean, dry, hairless skin on your lower belly as directed by the manufacturer. Press the patch firmly in place for 10 seconds, especially around the edges. Don't place it at your waistline or on your breasts.
  • Replace the patch twice a week (every 3-4 days) on a different area of your skin to help prevent skin irritation.
  • Fold together the sticky sides of used patches before throwing them away to avoid exposing others to the medicine. Don't flush them down the toilet.
  • Combipatch (estradiol / norethindrone patch) is not intended to be used forever. Talk to your doctor regularly to see if you still need treatment.
Learn more
More about ProveraSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Provera (medroxyprogesterone)?
Worth itNot sureNot worth it
More about CombipatchSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Combipatch (estradiol / norethindrone patch)?
Worth itNot sureNot worth it