Compare Provera vs. Elestrin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Regulates your menstrual cycle and supplements estrogen treatments for menopause.

Provera (Medroxyprogesterone) works well to regulate your menstrual cycle and stop irregular bleeding. It also protects the uterus from estrogen's harmful effects.

Relieves hot flashes due to menopause.

Elestrin (Estradiol gel) is a good, easy-to-use option if you don’t want to use pills or patches with estrogen hormones.

Upsides
  • Provera (Medroxyprogesterone) can be used to treat multiple hormone problems in women.
  • After menopause, taking estrogen raises your risk of uterine cancer. However, taking progesterone, like in Provera (Medroxyprogesterone), along with estrogen gives you the positive effects of estrogen, but also prevents it from damaging your uterus.
  • Women taking an estrogen/progestin combination medications have a lower risk of uterine cancer.
  • Elestrin (Estradiol gel) replaces estrogen to your whole body and relieves multiple symptoms due to low estrogen, like hot flashes and vaginal dryness.
  • Elestrin (Estradiol gel) is good for people who don't want to or can't take daily pills.
  • Elestrin (Estradiol gel) has fewer side effects than birht control pills since there are lower amounts of estrogen.
  • Most people start to feel better within 3-4 weeks of starting Elestrin (Estradiol gel).
Downsides
  • You can't take Provera (Medroxyprogesterone) if you've had a hysterectomy (your uterus removed). You also can't take it if you're pregnant or breastfeeding, have unusual vaginal bleeding, or have a history of blood clots, certain kinds of cancer, stroke, heart attack, liver problems, or bleeding problems.
  • Taking Elestrin (Estradiol gel) increases your risk for many conditions, like endometrial or breast cancer, dementia, heart disease, and blood clots.
  • You have to use Elestrin (Estradiol gel) with another hormone called progestin to lower your risk of uterine cancer.
  • Not a good option for people with liver problems.
  • It's possible to expose other people to the estrogen before it's absorbed by your skin.
  • Can be expensive since it's only available as a brand name product.
Used for
  • Amenorrhea
  • Abnormal uterine bleeding
  • Prevention of uterine cancer in women taking estrogen
  • Endometriosis
Dosage forms
  • Pill
  • Gel
Price
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Reviews
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Side effects
The Provera (Medroxyprogesterone) FDA package insert doesn’t have numbers about how common side effects are.
4possible side effects
  • Unusual vaginal bleeding
    9%
  • Common cold
    9%
  • Breast pain
    8%
  • Lung infection
    4%
See more detailed side effects
Risks and risk factors
  • Breast cancer
    • Personal or family history of breast cancer
  • Ovarian cancer
    • Family history of ovarian cancer
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Smoking
    • Obesity
    • Hypertension
    • Diabetes
    • High cholesterol
    • Systemic lupus erythematosus (SLE)
  • Depression
    • History of depression
  • Liver problems
    • History of liver problems
  • Harm to fetus
    • Women of childbearing age
See more detailed risks and warnings
  • Endometrial cancer
    • Using estrogen for more than one year
  • Breast cancer
    • Personal or family history of breast cancer
    • Using estrogen for more than one year
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Smoking
    • Obesity
    • Systemic lupus erythematosus (SLE)
  • Increased risk of heart disease
    • Smoking
    • Obesity
    • High blood pressure
    • High blood sugar
    • High cholesterol
    • Age 50 or older
  • Dementia
    • Age 65 or older
  • Pancreas swelling (pancreatitis)
    • High levels of triglycerides
See more detailed risks and warnings