Compare Provera vs. Minivelle

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Provera (Medroxyprogesterone)

Prescription only
Regulates your menstrual cycle and supplements estrogen treatments for menopause.

Provera (Medroxyprogesterone) works well to regulate your menstrual cycle and stop irregular bleeding. It also protects the uterus from estrogen's harmful effects.

Relieves menopause symptoms.

The Minivelle (estradiol patch) is the mini-me of estrogen patches. It's used twice a week, available in five strengths, and has the least amount of skin irritation.

5.8/ 7 average rating with 17 reviewsforMinivelle
Upsides
  • Provera (Medroxyprogesterone) can be used to treat multiple hormone problems in women.
  • After menopause, taking estrogen raises your risk of uterine cancer. However, taking progesterone, like in Provera (Medroxyprogesterone), along with estrogen gives you the positive effects of estrogen, but also prevents it from damaging your uterus.
  • Women taking an estrogen/progestin combination medications have a lower risk of uterine cancer.
  • Minivelle (estradiol patch) is the smallest estrogen patch available. It's the size a dime and comes in 5 different strengths.
  • Causes little or no skin irritation and doesn't leave much adhesive on your skin.
  • Minivelle (estradiol patch) replaces estrogen to your whole body and relieves many symptoms due to low estrogen, like hot flashes and vaginal dryness.
  • By using a patch instead of a pill, there's a lower risk of side effects such as blood clots and stroke since lower amounts of estrogen are used in patches.
  • Lowers your risk of fractures by keeping your bones healthy.
Downsides
  • You can't take Provera (Medroxyprogesterone) if you've had a hysterectomy (your uterus removed). You also can't take it if you're pregnant or breastfeeding, have unusual vaginal bleeding, or have a history of blood clots, certain kinds of cancer, stroke, heart attack, liver problems, or bleeding problems.
  • You need to replace Minivelle (estradiol patch) twice a week, compared to other patches that are once a week.
  • Patches can fall off.
  • Increases your risk of uterine and breast cancer.
  • Increases your risk of developing blood clots and stroke.
  • Can worsen other health conditions, like high cholesterol, asthma, diabetes, fluid retention, and migraines.
  • Can't be used in people with liver problems.
Used for
  • Amenorrhea
  • Abnormal uterine bleeding
  • Prevention of uterine cancer in women taking estrogen
  • Endometriosis
  • Hot flashes
  • Prevention of bone thinning in postmenopausal women
Dosage forms
  • Pill
  • Patch
Price
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$45.86
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$159.68
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Reviews
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17 
82%
think this treatment is worth it
76%
think this treatment works well
18%
think this treatment is a hassle

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Side effects
The Provera (Medroxyprogesterone) FDA package insert doesn’t have numbers about how common side effects are.
10possible side effects
  • Headache
    26%
  • Breast pain
    13%
  • Back pain
    11%
  • Menstrual bleeding
    11%
  • Influenza
    8%
  • Common cold
    8%
  • Nausea
    5%
  • Pain
    5%
  • Sinus infection
    5%
  • Lung infection
    5%
See more detailed side effects
Risks and warnings
  • Breast cancer

    Personal or family history of breast cancer

  • Ovarian cancer

    Family history of ovarian cancer

  • Increased risk of blood clots and stroke

    Personal or family history of blood clots

    ...and 6 more risk factors

  • Depression

    History of depression

  • Liver problems

    History of liver problems

  • Harm to fetus

    Women of childbearing age

See more detailed risks and warnings
  • Endometrial cancer

    Using estrogen for more than one year

  • Breast cancer

    Personal or family history of breast cancer

    ...and 1 more risk factors

  • Increased risk of blood clots and stroke

    Personal or family history of blood clots

    ...and 3 more risk factors

  • Increased risk of heart disease

    Smoking

    ...and 5 more risk factors

  • Dementia

    Age 65 or older

  • Pancreas swelling (pancreatitis)

    High levels of triglycerides

See more detailed risks and warnings