Compare Provera vs. Prometrium

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Regulates your menstrual cycle and supplements estrogen treatments for menopause.

Provera (Medroxyprogesterone) works well to regulate your menstrual cycle and stop irregular bleeding. It also protects the uterus from estrogen's harmful effects.

Taken for irregular bleeding or paired with estrogen replacements for menopause.

Prometrium (Progesterone) regulates menstrual cycles, treats heavy bleeding, and prevents thickening of the uterus.

3.4/ 5 average rating with 64 reviewsforPrometrium
Upsides
  • Provera (Medroxyprogesterone) can be used to treat multiple hormone problems in women.
  • After menopause, taking estrogen raises your risk of uterine cancer. However, taking progesterone, like in Provera (Medroxyprogesterone), along with estrogen gives you the positive effects of estrogen, but also prevents it from damaging your uterus.
  • Women taking an estrogen/progestin combination medications have a lower risk of uterine cancer.
  • Helps to regulate your menstrual cycle.
  • Relives pain from endometriosis.
  • Lowers the risk of uterine cancer when used with estrogen in women with an intact uterus.
  • Available as a capsule or an injection, so you can choose what works best for you.
Downsides
  • You can't take Provera (Medroxyprogesterone) if you've had a hysterectomy (your uterus removed). You also can't take it if you're pregnant or breastfeeding, have unusual vaginal bleeding, or have a history of blood clots, certain kinds of cancer, stroke, heart attack, liver problems, or bleeding problems.
  • Prometrium (Progesterone) capsules contain peanut oil, so you can't take it if you're allergic to peanuts.
  • Prometrium (Progesterone) can cause serious birth defects in babies, so you can't take Prometrium (Progesterone) if you’re pregnant or breast-feeding.
  • Increases your risk of blood clots.
Used for
  • Amenorrhea
  • Abnormal uterine bleeding
  • Prevention of uterine cancer in women taking estrogen
  • Endometriosis
  • Amenorrhea
  • Prevention of uterine cancer in women taking estrogen
  • Abnormal uterine bleeding
Dosage forms
  • Pill
  • Pill
  • Injection
Price
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Reviews
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64 reviews so far
61%
saidit'sworth it
41%
saiditworked well
17%
saidit'sa big hassle

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Side effects
The Provera (Medroxyprogesterone) FDA package insert doesn’t have numbers about how common side effects are.
The Prometrium (Progesterone) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Breast cancer
    • Personal or family history of breast cancer
  • Ovarian cancer
    • Family history of ovarian cancer
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Smoking
    • Obesity
    • Hypertension
    • Diabetes
    • High cholesterol
    • Systemic lupus erythematosus (SLE)
  • Depression
    • History of depression
  • Liver problems
    • History of liver problems
  • Harm to fetus
    • Women of childbearing age
See more detailed risks and warnings
  • Breast cancer
    • Personal or family history of breast cancer
  • Ovarian cancer
    • Family history of ovarian cancer
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Smoking
    • Obesity
    • Hypertension
    • Diabetes
    • High cholesterol
    • Systemic lupus erythematosus (SLE)
  • Severe allergic reactions
    • Allergy to peanuts
  • Fluid retention (Foot and leg swelling)
    • Heart failure
    • Kidney problems
    • Obesity
  • Depression
    • History of depression
See more detailed risks and warnings