Compare Provera vs. Prometrium

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Provera
(medroxyprogesterone)

Prometrium
(progesterone)

Regulates your menstrual cycle and supplements estrogen treatments for menopause. Provera (Medroxyprogesterone) works well to regulate your menstrual cycle and stop irregular bleeding. It also protects the uterus from estrogen's harmful effects.Taken for irregular bleeding or paired with estrogen replacements for menopause. Prometrium (Progesterone) regulates menstrual cycles, treats heavy bleeding, and prevents thickening of the uterus.
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Coupons for Provera
Best available price for 10 (10mg) tablets of provera
Coupons for Prometrium
Best available price for 30 (100mg) capsules of prometrium
Reviews & ratings
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Have you used Provera (medroxyprogesterone)?
Worth itNot sureNot worth it
Reviews for Prometrium
61%
-1% worse vs. Provera
41%
-1% worse vs. Provera
17%
-23% worse vs. Provera
Have you used Prometrium (progesterone)?
Worth itNot sureNot worth it
Side effects
ProveraPrometrium

We haven’t found good data for Provera side effects.

FDA side effect reports for Provera »
  • Headache 4%
  • Breast tenderness 21%
  • Low mood disorder 7%
  • Dizziness 6%
  • Abdominal bloating 7%
  • Urinary problems 2%
  • Vaginal discharge 7%
More Prometrium side effects »
How it works
ProveraPrometrium
Provera (Medroxyprogesterone) contains medroxyprogesterone, a progesterone hormone that works to balance hormone changes in the body. In premenopausal women, it prevents thickening of the uterus lining and regulates your menstrual cycle. It's also added to hormone therapy to protect the uterus from the harmful effects of estrogen.Prometrium (Progesterone) contains progesterone, a hormone that regulates the menstrual cycle and protects the uterus from the negative effects of estrogen when used for postmenopausal treatment.
Type of medication
ProveraPrometrium
Prescription onlyPrescription only
Available as
ProveraPrometrium
  • Pill
  • Pill
  • Injection
Used for
ProveraPrometrium
  • Amenorrhea
  • Amenorrhea
Risk factors for serious side effects
ProveraPrometrium
  • Personal or family history of breast cancer
  • Family history of ovarian cancer
  • Personal or family history of blood clots
  • Smoking
  • Obesity
Detailed Provera (medroxyprogesterone) risks & warnings »
  • Personal or family history of breast cancer
  • Family history of ovarian cancer
  • Personal or family history of blood clots
  • Smoking
  • Obesity
Detailed Prometrium (progesterone) risks & warnings »
Pregnancy

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Pain
ProveraPrometrium
No pain related info.
  • Relives pain from endometriosis.
  • Tell your doctor about any severe stomach pain or yellowing of your eyes or skin.
Weight
ProveraPrometrium
  • Can cause headache, weight gain, breast tenderness, or changes in mood.
  • Provera (Medroxyprogesterone) contains progestin. It could cause a higher risk of ovarian cancer, especially if you have a family history of it. Your doctor can help you weigh the risks versus the benefits of this medication.
  • Can cause cramps, bloating, trouble sleeping, acne, weight gain, facial skin discoloration, or irregular periods.
  • Prometrium (Progesterone) contains progestin. It could cause a higher risk of ovarian cancer, especially if you have a family history of it. Your doctor can help you weigh the risks versus the benefits of this medication.
Upsides and benefits
ProveraPrometrium
  • Provera (Medroxyprogesterone) can be used to treat multiple hormone problems in women.
  • After menopause, taking estrogen raises your risk of uterine cancer. However, taking progesterone, like in Provera (Medroxyprogesterone), along with estrogen gives you the positive effects of estrogen, but also prevents it from damaging your uterus.
  • Women taking an estrogen/progestin combination medications have a lower risk of uterine cancer.
  • Helps to regulate your menstrual cycle.
  • Relives pain from endometriosis.
  • Lowers the risk of uterine cancer when used with estrogen in women with an intact uterus.
  • Available as a capsule or an injection, so you can choose what works best for you.
Downsides and risks
ProveraPrometrium
  • You can't take Provera (Medroxyprogesterone) if you've had a hysterectomy (your uterus removed). You also can't take it if you're pregnant or breastfeeding, have unusual vaginal bleeding, or have a history of blood clots, certain kinds of cancer, stroke, heart attack, liver problems, or bleeding problems.
  • Prometrium (Progesterone) capsules contain peanut oil, so you can't take it if you're allergic to peanuts.
  • Prometrium (Progesterone) can cause serious birth defects in babies, so you can't take Prometrium (Progesterone) if you’re pregnant or breast-feeding.
  • Increases your risk of blood clots.
Tips from our pharmacists for people taking the medication
ProveraPrometrium
  • The dose of Provera (Medroxyprogesterone) will be different depending on what you’re using it for, so take it exactly the way your doctor tells you.
  • Talk to your doctor every few months about using the lowest possible dose of Provera (Medroxyprogesterone). Since there can be a lot of long-term side effects, take it only as long as you need it.
  • Can cause headache, weight gain, breast tenderness, or changes in mood.
  • If you're taking Provera (Medroxyprogesterone) to regulate your period, you'll get withdrawal bleeding 3 to 7 days after stopping Provera (Medroxyprogesterone).
  • The dose of Prometrium (Progesterone) will be different depending on what you’re using it for, so take it exactly the way your doctor tells you.
  • It's important to take it the same time every day.
  • Prometrium (Progesterone) capsules can make you feel tired or dizzy, so take it just before you go to sleep every night.
  • If you have trouble swallowing the capsule, take it with a full glass of water while standing up.
  • Can cause cramps, bloating, trouble sleeping, acne, weight gain, facial skin discoloration, or irregular periods.
  • Tell your doctor about any severe stomach pain or yellowing of your eyes or skin.
  • Get immediate medical help if you have sudden vision changes or one-sided weakness (signs of stroke) or chest pain and trouble breathing (signs of a pulmonary embolism).
Learn more
More about ProveraSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Provera (medroxyprogesterone)?
Worth itNot sureNot worth it
More about PrometriumSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Prometrium (progesterone)?
Worth itNot sureNot worth it