Compare Provigil vs. Desoxyn

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Provigil
(Modafinil)

Desoxyn
(Methamphetamine)

Improves alertness. Provigil (Modafinil) is effective in improving alertness, but it can interact with other medicines and shouldn't be used long-term.Helps you focus and lose weight. Desoxyn (Methamphetamine) is an effective and cheap medication used to treat ADHD, but it can be habit-forming and is not used for long-term treatment.
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Reviews & ratings
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Have you used Provigil (Modafinil)?
Worth itNot sureNot worth it

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Have you used Desoxyn (Methamphetamine)?
Worth itNot sureNot worth it
Side effects
ProvigilDesoxyn
  • Headache 11%
  • Nausea 8%
  • Any side effect 5%
  • Nervousness 4%
  • Sleep difficulty 4%
  • Anxiety 4%
  • Loss of appetite 3%
  • Dry mouth 2%
  • Sore throat 2%
  • Chest pain 2%
More Provigil side effects »

We haven’t found good data for Desoxyn side effects.

FDA side effect reports for Desoxyn »
How it works
ProvigilDesoxyn
Provigil (Modafinil) is a stimulant that helps you feel awake. Researchers don't know exactly how Provigil (Modafinil) works, but it probably affects chemicals (neurotransmitters) in the brain.Desoxyn (Methamphetamine) is a stimulant. It treats attention-deficit/hyperactivity disorder (ADHD) and weight loss by increasing norepinephrine and dopamine activity in the brain.
Type of medication
ProvigilDesoxyn
StimulantPrescription only
StimulantPrescription only
Available as
ProvigilDesoxyn
  • Pill
  • Pill
Used for (click to learn more)
ProvigilDesoxyn
Risk factors for serious side effects
ProvigilDesoxyn
  • Taking with alcohol
  • Taking other medicines that make you less alert
      • Current kidney problems
      • Current liver problems
      • History of heart problems
      • History of psychiatric disorder
      • History of bipolar disorder
      Detailed Provigil (Modafinil) risks & warnings »
      • History of heart problems
      • History of drug abuse
      • History of psychotic episodes
      • History of Bipolar Disorder
      • Children
      • History of seizures
      • Women of childbearing age
      • Breast-feeding
      • Taking MAO inhibitors, insulin and other high blood pressure medicine
      Detailed Desoxyn (Methamphetamine) risks & warnings »
      Pregnancy

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Interactions
      ProvigilDesoxyn
      • Interacts with many other medications.
      No interactions related info.
      Alcohol
      ProvigilDesoxyn
      • Don't drink alcohol with Provigil (Modafinil).
      No alcohol related info.
      Kidneys and liver
      ProvigilDesoxyn
      • Not a good choice if you have liver or kidney problems.
      • Provigil (Modafinil) is broken down by the kidney and liver. If you have kidney or liver problems, you may need to use a lower dose to prevent more side effects.
      No kidneys and liver related info.
      Weight
      ProvigilDesoxyn
      No weight related info.
      • Only recommended for weight loss if other medications and plans haven't worked.
      • If you're taking Desoxyn (Methamphetamine) for weight loss, take it 30 minutes before a meal. Desoxyn (Methamphetamine) can affect your concentration, so don't drive or do anything that requires concentration until you know how your body reacts to it.
      Upsides and benefits
      ProvigilDesoxyn
      • It's a non-amphetamine medicine that helps improve alertness.
      • Available in a generic version.
      • Effective in reducing excessive sleepiness in Shift-work Sleep Disorder.
      • Doesn't negatively affect daytime sleep.
      • Recommended as a first-choice medication to treat ADHD in both adults and children.
      • Available as a generic, so it is cheaper than other medications to treat ADHD.
      Downsides and risks
      ProvigilDesoxyn
      • Provigil (Modafinil) can be habit-forming, so it's typically not used for long-term treatment.
      • Interacts with many other medications.
      • Taking Provigil (Modafinil) will make hormonal birth control less effective. You should definitely use additional forms of non-hormonal contraception.
      • Not a good choice if you have liver or kidney problems.
      • Only recommended for weight loss if other medications and plans haven't worked.
      • Only used for short-term treatment because it is habit-forming.
      • If you want to stop taking Desoxyn (Methamphetamine), talk to your doctor since stopping can cause withdrawal symptoms.
      • Not safe for use in children younger than 12 years.
      Tips from our pharmacists for people taking the medication
      ProvigilDesoxyn
      • Take Provigil (Modafinil) about an hour before you need to be fully alert.
      • Taking caffeine with Provigil (Modafinil) can cause you to feel nervous, shaky, and have a faster heartbeat. Try limiting your caffeine intake.
      • Until you know how Provigil (Modafinil) makes you feel, don't drive or perform any tasks that need you to be alert.
      • You can experience withdrawal symptoms if you suddenly stop taking Provigil (Modafinil). Talk to your doctor before making any changes.
      • Tell your doctor right away if you break out in a rash.
      • Don't drink alcohol with Provigil (Modafinil).
      • Don't take Desoxyn (Methamphetamine) in the evening or you won't be able to sleep.
      • If you're taking Desoxyn (Methamphetamine) for weight loss, take it 30 minutes before a meal. Desoxyn (Methamphetamine) can affect your concentration, so don't drive or do anything that requires concentration until you know how your body reacts to it.
      • Desoxyn (Methamphetamine) is only meant to be used for a few weeks since it can be habit-forming and lose its effectiveness.
      • Can cause reduced appetite, insomnia, and restlessness.
      Learn more
      More about ProvigilSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Provigil (Modafinil)?
      Worth itNot sureNot worth it
      More about DesoxynSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Desoxyn (Methamphetamine)?
      Worth itNot sureNot worth it