Compare Provigil vs. Desoxyn

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Provigil
(Modafinil)

Desoxyn
(Methamphetamine)

Improves alertness. Provigil (Modafinil) is effective in improving alertness, but it can interact with other medicines and shouldn't be used long-term.Helps you focus and lose weight. Desoxyn (Methamphetamine) is an effective and cheap medication used to treat ADHD, but it can be habit-forming and is not used for long-term treatment.
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Reviews & ratings
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5.565217391304348Provigil
Reviews for Provigil (Modafinil)
78%
of people say Provigil (Modafinil) is worth it
70%
say it works well
4%
say it's a big hassle

Not enough reviews for this drug. Help someone out, leave a review!

Side effects
ProvigilDesoxyn
  • Headache 11%
  • Nausea 8%
  • Any side effect 5%
  • Nervousness 4%
  • Sleep difficulty 4%
  • Anxiety 4%
  • Loss of appetite 3%
  • Dry mouth 2%
  • Sore throat 2%
  • Chest pain 2%
More Provigil side effects »

We haven’t found good data for Desoxyn side effects.

FDA side effect reports for Desoxyn »
How it works
ProvigilDesoxyn
Provigil (Modafinil) is a stimulant that helps you feel awake. Researchers don't know exactly how Provigil (Modafinil) works, but it probably affects chemicals (neurotransmitters) in the brain.Desoxyn (Methamphetamine) is a stimulant. It treats attention-deficit/hyperactivity disorder (ADHD) and weight loss by increasing norepinephrine and dopamine activity in the brain.
Type of medication
ProvigilDesoxyn
StimulantPrescription only
StimulantPrescription only
Available as
ProvigilDesoxyn
  • Pill
  • Pill
Used for (click to learn more)
ProvigilDesoxyn
Risk factors for serious side effects
ProvigilDesoxyn
  • Taking with alcohol
  • Taking other medicines that make you less alert
      • Current kidney problems
      • Current liver problems
      • History of heart problems
      • History of psychiatric disorder
      • History of bipolar disorder
      Detailed Provigil (Modafinil) risks & warnings »
      • History of heart problems
      • History of drug abuse
      • History of psychotic episodes
      • History of Bipolar Disorder
      • Children
      • History of seizures
      • Women of childbearing age
      • Breast-feeding
      • Taking MAO inhibitors, insulin and other high blood pressure medicine
      Detailed Desoxyn (Methamphetamine) risks & warnings »
      Pregnancy category
      ProvigilDesoxyn
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      Alcohol
      • Don't drink alcohol with Provigil (Modafinil).
      No specific alcohol-related info.
      Food
      No specific food-related info.
      • If you're taking Desoxyn (Methamphetamine) for weight loss, take it 30 minutes before a meal. Desoxyn (Methamphetamine) can affect your concentration, so don't drive or do anything that requires concentration until you know how your body reacts to it.
      Kidneys and liver
      • Not a good choice if you have liver or kidney problems.
      • Provigil (Modafinil) is broken down by the kidney and liver. If you have kidney or liver problems, you may need to use a lower dose to prevent more side effects.
      No specific kidneys and liver-related info.
      Sex
      No specific sex-related info.No specific sex-related info.
      Sleep
      • Effective in reducing excessive sleepiness in Shift-work Sleep Disorder.
      • Doesn't negatively affect daytime sleep.
      • Don't take Desoxyn (Methamphetamine) in the evening or you won't be able to sleep.
      Weight
      No specific weight-related info.
      • Only recommended for weight loss if other medications and plans haven't worked.
      • If you're taking Desoxyn (Methamphetamine) for weight loss, take it 30 minutes before a meal. Desoxyn (Methamphetamine) can affect your concentration, so don't drive or do anything that requires concentration until you know how your body reacts to it.
      • Appetite suppression can occur. In clinical studies, long-term treatment with stimulants similar to Desoxyn (Methamphetamine) caused a temporary slowing of growth rate (both height and weight) in children who started the medication before they started puberty. Doctors should monitor children's growth during treatment.
      Upsides and benefits
      ProvigilDesoxyn
      • It's a non-amphetamine medicine that helps improve alertness.
      • Available in a generic version.
      • Effective in reducing excessive sleepiness in Shift-work Sleep Disorder.
      • Doesn't negatively affect daytime sleep.
      • Recommended as a first-choice medication to treat ADHD in both adults and children.
      • Available as a generic, so it is cheaper than other medications to treat ADHD.
      Downsides and risks
      ProvigilDesoxyn
      • Provigil (Modafinil) can be habit-forming, so it's typically not used for long-term treatment.
      • Interacts with many other medications.
      • Taking Provigil (Modafinil) will make hormonal birth control less effective. You should definitely use additional forms of non-hormonal contraception.
      • Not a good choice if you have liver or kidney problems.
      • Only recommended for weight loss if other medications and plans haven't worked.
      • Only used for short-term treatment because it is habit-forming.
      • If you want to stop taking Desoxyn (Methamphetamine), talk to your doctor since stopping can cause withdrawal symptoms.
      • Not safe for use in children younger than 12 years.
      Tips from our pharmacists for people taking the medication
      ProvigilDesoxyn
      • Take Provigil (Modafinil) about an hour before you need to be fully alert.
      • Taking caffeine with Provigil (Modafinil) can cause you to feel nervous, shaky, and have a faster heartbeat. Try limiting your caffeine intake.
      • Until you know how Provigil (Modafinil) makes you feel, don't drive or perform any tasks that need you to be alert.
      • You can experience withdrawal symptoms if you suddenly stop taking Provigil (Modafinil). Talk to your doctor before making any changes.
      • Tell your doctor right away if you break out in a rash.
      • Don't drink alcohol with Provigil (Modafinil).
      • Don't take Desoxyn (Methamphetamine) in the evening or you won't be able to sleep.
      • If you're taking Desoxyn (Methamphetamine) for weight loss, take it 30 minutes before a meal. Desoxyn (Methamphetamine) can affect your concentration, so don't drive or do anything that requires concentration until you know how your body reacts to it.
      • Desoxyn (Methamphetamine) is only meant to be used for a few weeks since it can be habit-forming and lose its effectiveness.
      • Can cause reduced appetite, insomnia, and restlessness.
      Learn more
      More about ProvigilSide effectsReviews & ratingsAlternativesFDA package insert
      More about DesoxynSide effectsReviews & ratingsAlternativesFDA package insert