Compare Provigil vs. Desoxyn

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Provigil
(modafinil)

Desoxyn
(methamphetamine)

Improves alertness. Provigil (Modafinil) is effective in improving alertness, but it can interact with other medicines and shouldn't be used long-term.Helps you focus and lose weight. Desoxyn (Methamphetamine) is an effective and cheap medication used to treat ADHD, but it can be habit-forming and is not used for long-term treatment.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.75Provigil
Reviews for Provigil
82%
of people (All ages) say Provigil is worth it
71%
say it works well
4%
say it's a big hassle
Have you used Provigil (modafinil)?
Worth itNot sureNot worth it
Reviews for Desoxyn
84%
-2% worse vs. Provigil
79%
-8% worse vs. Provigil
11%
+7% better vs. Provigil
Have you used Desoxyn (methamphetamine)?
Worth itNot sureNot worth it
Side effects
ProvigilDesoxyn
  • Headache 11%
  • Nausea 8%
  • Any side effect 5%
  • Inflammation inside the nose 1%
  • Nervousness 4%
  • Back pain 1%
  • Diarrhea 1%
  • Dizziness 1%
  • Sleep difficulty 4%
  • Indigestion 1%
More Provigil side effects »

We haven’t found good data for Desoxyn side effects.

FDA side effect reports for Desoxyn »
How it works
ProvigilDesoxyn
Provigil (Modafinil) is a stimulant that helps you feel awake. Researchers don't know exactly how Provigil (Modafinil) works, but it probably affects chemicals (neurotransmitters) in the brain.Desoxyn (Methamphetamine) is a stimulant. It treats attention-deficit/hyperactivity disorder (ADHD) and weight loss by increasing norepinephrine and dopamine activity in the brain.
Type of medication
ProvigilDesoxyn
Prescription onlyPrescription only
Available as
ProvigilDesoxyn
  • Pill
  • Pill
Used for
ProvigilDesoxyn
Risk factors for serious side effects
ProvigilDesoxyn
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Current kidney problems
  • Current liver problems
  • History of heart problems
Detailed Provigil (modafinil) risks & warnings »
  • History of heart problems
  • History of drug abuse
  • History of psychotic episodes
  • History of Bipolar Disorder
  • Children
Detailed Desoxyn (methamphetamine) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
ProvigilDesoxyn
  • Interacts with many other medications.
No interactions related info.
Alcohol
ProvigilDesoxyn
  • Don't drink alcohol with Provigil (Modafinil).
No alcohol related info.
Kidneys and liver
ProvigilDesoxyn
  • Provigil (Modafinil) is broken down by the kidney and liver. If you have kidney or liver problems, you may need to use a lower dose to prevent more side effects.
  • Not a good choice if you have liver or kidney problems.
No kidneys and liver related info.
Weight
ProvigilDesoxyn
No weight related info.
  • If you're taking Desoxyn (Methamphetamine) for weight loss, take it 30 minutes before a meal. Desoxyn (Methamphetamine) can affect your concentration, so don't drive or do anything that requires concentration until you know how your body reacts to it.
  • Only recommended for weight loss if other medications and plans haven't worked.
Upsides and benefits
ProvigilDesoxyn
  • It's a non-amphetamine medicine that helps improve alertness.
  • Available in a generic version.
  • Effective in reducing excessive sleepiness in Shift-work Sleep Disorder.
  • Doesn't negatively affect daytime sleep.
  • Recommended as a first-choice medication to treat ADHD in both adults and children.
  • Available as a generic, so it is cheaper than other medications to treat ADHD.
Downsides and risks
ProvigilDesoxyn
  • Provigil (Modafinil) can be habit-forming, so it's typically not used for long-term treatment.
  • Interacts with many other medications.
  • Taking Provigil (Modafinil) will make hormonal birth control less effective. You should definitely use additional forms of non-hormonal contraception.
  • Not a good choice if you have liver or kidney problems.
  • Only recommended for weight loss if other medications and plans haven't worked.
  • Only used for short-term treatment because it is habit-forming.
  • If you want to stop taking Desoxyn (Methamphetamine), talk to your doctor since stopping can cause withdrawal symptoms.
  • Not safe for use in children younger than 12 years.
Tips from our pharmacists for people taking the medication
ProvigilDesoxyn
  • Take Provigil (Modafinil) about an hour before you need to be fully alert.
  • Taking caffeine with Provigil (Modafinil) can cause you to feel nervous, shaky, and have a faster heartbeat. Try limiting your caffeine intake.
  • Until you know how Provigil (Modafinil) makes you feel, don't drive or perform any tasks that need you to be alert.
  • You can experience withdrawal symptoms if you suddenly stop taking Provigil (Modafinil). Talk to your doctor before making any changes.
  • Tell your doctor right away if you break out in a rash.
  • Don't drink alcohol with Provigil (Modafinil).
  • Don't take Desoxyn (Methamphetamine) in the evening or you won't be able to sleep.
  • If you're taking Desoxyn (Methamphetamine) for weight loss, take it 30 minutes before a meal. Desoxyn (Methamphetamine) can affect your concentration, so don't drive or do anything that requires concentration until you know how your body reacts to it.
  • Desoxyn (Methamphetamine) is only meant to be used for a few weeks since it can be habit-forming and lose its effectiveness.
  • Can cause reduced appetite, insomnia, and restlessness.
Learn more
More about ProvigilSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Provigil (modafinil)?
Worth itNot sureNot worth it
More about DesoxynSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Desoxyn (methamphetamine)?
Worth itNot sureNot worth it