Compare Provigil vs. Dexedrine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Provigil (Modafinil)

Prescription only
Improves alertness.

Provigil (Modafinil) is effective in improving alertness, but it can interact with other medicines and shouldn't be used long-term.

5.8/ 7 average rating with 28 reviewsforProvigil
Treats attention deficit disorder.

Dexedrine (dextroamphetamine) is an effective medicine for treatment of ADHD, but often abused for recreational purposes.

5.9/ 7 average rating with 28 reviewsforDexedrine
Upsides
  • It's a non-amphetamine medicine that helps improve alertness.
  • Available in a generic version.
  • Effective in reducing excessive sleepiness in Shift-work Sleep Disorder.
  • Doesn't negatively affect daytime sleep.
  • Recommended as a first-choice treatment of ADHD.
  • Available as generic version.
  • For more flexible dosing schedule, Dexedrine (dextroamphetamine) is available in short and long formulations.
  • If you have difficulty swallowing pills, Dexedrine (dextroamphetamine) is available as a liquid.
Downsides
  • Provigil (Modafinil) can be habit-forming, so it's typically not used for long-term treatment.
  • Interacts with many other medications.
  • Taking Provigil (Modafinil) will make hormonal birth control less effective. You should definitely use additional forms of non-hormonal contraception.
  • Not a good choice if you have liver or kidney problems.
  • Taking Dexedrine (dextroamphetamine) can decrease your appetite.
  • If taken late in the day, Dexedrine (dextroamphetamine) can cause insomnia.
  • People who take high doses of Dexedrine (dextroamphetamine) are more likely to have anxiety, restlessness, or irritability.
  • Requires a new prescription from your doctor every month.
  • Not a good option if you have a history of seizures.
  • Can be habit-forming so make sure you use it only as prescribed.
Used for
Dosage forms
  • Pill
  • Pill
  • Extended release
  • Liquid
Price
Lowest price near you
$35
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$54.11
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Reviews
28 
82%
think this treatment is worth it
71%
think this treatment works well
4%
think this treatment is a hassle

Have you used Provigil (Modafinil)?

Leave a review
28 
89%
think this treatment is worth it
79%
think this treatment works well
21%
think this treatment is a hassle

Have you used Dexedrine (dextroamphetamine)?

Leave a review
Side effects
10possible side effects
  • Headache
    34%
  • Nausea
    11%
  • Any side effect
    8%
  • Nervousness
    7%
  • Rhinitis
    7%
  • Back Pain
    6%
  • Diarrhea
    6%
  • Dyspepsia
    5%
  • Insomnia
    5%
  • Anxiety
    5%
See more detailed side effects
The Dexedrine (dextroamphetamine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Driving impairment

    Taking with alcohol

    ...and 1 more risk factors

  • Increased side effects

    Current kidney problems

    ...and 1 more risk factors

  • Heart problems

    History of heart problems

  • Suicidal thoughts or behavior | Mania

    History of psychiatric disorder

    ...and 1 more risk factors

See more detailed risks and warnings
  • Abuse and dependence

    History of drug abuse

  • Serious or life-threatening heart problems

    History of heart problems

  • Aggressive behavior and psychosis

    History of psychotic episodes

    ...and 1 more risk factors

  • Long-term growth suppression

    Children

  • Seizures

    History of seizures

  • Serotonin Syndrome (rare, life-threatening)

    Using other medicines that increase serotonin levels in the brain

See more detailed risks and warnings