Compare Provigil vs. Dexedrine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Provigil
(Modafinil)

Dexedrine
(Dextroamphetamine)

Improves alertness. Provigil (Modafinil) is effective in improving alertness, but it can interact with other medicines and shouldn't be used long-term.Helps you stay awake and focus. Dexedrine (Dextroamphetamine) is an effective and cheap medication used to treat ADHD, but it can be habit-forming and is not used for long-term treatment.
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Reviews & ratings
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Have you used Provigil (Modafinil)?
Worth itNot sureNot worth it

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Have you used Dexedrine (Dextroamphetamine)?
Worth itNot sureNot worth it
Side effects
ProvigilDexedrine
  • Headache 11%
  • Nausea 8%
  • Any side effect 5%
  • Nervousness 4%
  • Sleep difficulty 4%
  • Anxiety 4%
  • Loss of appetite 3%
  • Dry mouth 2%
  • Sore throat 2%
  • Chest pain 2%
More Provigil side effects »

We haven’t found good data for Dexedrine side effects.

FDA side effect reports for Dexedrine »
How it works
ProvigilDexedrine
Provigil (Modafinil) is a stimulant that helps you feel awake. Researchers don't know exactly how Provigil (Modafinil) works, but it probably affects chemicals (neurotransmitters) in the brain.Dexedrine (Dextroamphetamine) is a stimulant. It treats narcolepsy and attention-deficit/hyperactivity disorder (ADHD) by increasing norepinephrine and dopamine activity in the brain.
Type of medication
ProvigilDexedrine
StimulantPrescription only
StimulantPrescription only
Available as
ProvigilDexedrine
  • Pill
  • Pill
  • Extended release
  • Liquid
Used for (click to learn more)
ProvigilDexedrine
Risk factors for serious side effects
ProvigilDexedrine
  • Taking with alcohol
  • Taking other medicines that make you less alert
      • Current kidney problems
      • Current liver problems
      • History of heart problems
      • History of psychiatric disorder
      • History of bipolar disorder
      Detailed Provigil (Modafinil) risks & warnings »
      • History of heart problems
      • History of drug abuse
      • History of psychotic episodes
      • History of bipolar disorder
      • Children
      • History of seizures
      • Women of childbearing age
      • Breastfeeding
      • Use of MAO inhibitors
      Detailed Dexedrine (Dextroamphetamine) risks & warnings »
      Pregnancy

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Interactions
      ProvigilDexedrine
      • Interacts with many other medications.
      No interactions related info.
      Alcohol
      ProvigilDexedrine
      • Don't drink alcohol with Provigil (Modafinil).
      No alcohol related info.
      Kidneys and liver
      ProvigilDexedrine
      • Not a good choice if you have liver or kidney problems.
      • Provigil (Modafinil) is broken down by the kidney and liver. If you have kidney or liver problems, you may need to use a lower dose to prevent more side effects.
      No kidneys and liver related info.
      Upsides and benefits
      ProvigilDexedrine
      • It's a non-amphetamine medicine that helps improve alertness.
      • Available in a generic version.
      • Effective in reducing excessive sleepiness in Shift-work Sleep Disorder.
      • Doesn't negatively affect daytime sleep.
      • Recommended as a first-choice medication to treat ADHD in both adults and children.
      • Available as a generic, so it is cheaper than other medications used to treat ADHD.
      • Available in an immediate release and extended release form, which allows for once or twice a day dosing.
      Downsides and risks
      ProvigilDexedrine
      • Provigil (Modafinil) can be habit-forming, so it's typically not used for long-term treatment.
      • Interacts with many other medications.
      • Taking Provigil (Modafinil) will make hormonal birth control less effective. You should definitely use additional forms of non-hormonal contraception.
      • Not a good choice if you have liver or kidney problems.
      • Fruit juice lowers the amount of Dexedrine (Dextroamphetamine) that gets into your body.
      • If you want to stop taking Dexedrine (Dextroamphetamine), you have to talk to your doctor since stopping cold turkey can cause withdrawal symptoms.
      • Dexedrine (Dextroamphetamine) is usually not used long-term since it can be habit-forming.
      Tips from our pharmacists for people taking the medication
      ProvigilDexedrine
      • Take Provigil (Modafinil) about an hour before you need to be fully alert.
      • Taking caffeine with Provigil (Modafinil) can cause you to feel nervous, shaky, and have a faster heartbeat. Try limiting your caffeine intake.
      • Until you know how Provigil (Modafinil) makes you feel, don't drive or perform any tasks that need you to be alert.
      • You can experience withdrawal symptoms if you suddenly stop taking Provigil (Modafinil). Talk to your doctor before making any changes.
      • Tell your doctor right away if you break out in a rash.
      • Don't drink alcohol with Provigil (Modafinil).
      • Take your last dose before early afternoon, otherwise you won't be able to sleep.
      • Don't take with fruit juice or vitamin C, because they'll lower the amount of Dexedrine (Dextroamphetamine) that gets into your body.
      • Can affect your concentration, so don't drive or do anything that requires concentration until you know how your body reacts to it.
      • If you've been taking Dexedrine (Dextroamphetamine) for a while and decide to stop it, you'll experience withdrawal symptoms if you stop it too fast.
      • Can cause reduced appetite, insomnia, and restlessness.
      Learn more
      More about ProvigilSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Provigil (Modafinil)?
      Worth itNot sureNot worth it
      More about DexedrineSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Dexedrine (Dextroamphetamine)?
      Worth itNot sureNot worth it