Compare Provigil vs. Kapvay

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Provigil
(Modafinil)

Kapvay
(Clonidine)

Improves alertness. Provigil (Modafinil) is effective in improving alertness, but it can interact with other medicines and shouldn't be used long-term.Treats ADHD and lowers blood pressure. Clonidine is a non-stimulant option to manage ADHD symptoms and behaviors, but it can lower your blood pressure.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.565217391304348Provigil
Reviews for Provigil (Modafinil)
78%
of people say Provigil (Modafinil) is worth it
70%
say it works well
4%
say it's a big hassle

Not enough reviews for this drug. Help someone out, leave a review!

Side effects
ProvigilKapvay
  • Headache 11%
  • Nausea 8%
  • Any side effect 5%
  • Nervousness 4%
  • Sleep difficulty 4%
  • Anxiety 4%
  • Loss of appetite 3%
  • Dry mouth 2%
  • Sore throat 2%
  • Chest pain 2%
More Provigil side effects »
  • Drowsiness 34%
  • Any side effect 19%
  • Fatigue 15%
  • Irritability 5%
  • Sleep difficulty 5%
  • Headache 4%
  • Dry mouth 4%
  • Upper abdominal pain 3%
  • Emotional disorder 3%
  • Dizziness 2%
More Kapvay side effects »
How it works
ProvigilKapvay
Provigil (Modafinil) is a stimulant that helps you feel awake. Researchers don't know exactly how Provigil (Modafinil) works, but it probably affects chemicals (neurotransmitters) in the brain.Clonidine is an alpha-2 agonist. Researchers don't know exactly how it works for ADHD. It works in the brain and lowers the activity of certain stress hormones, but it's not a stimulant like many ADHD medicines.
Type of medication
ProvigilKapvay
StimulantPrescription only
Antihypertensive
Alpha agonist
Prescription only
Available as
ProvigilKapvay
  • Pill
  • Extended release
Used for (click to learn more)
ProvigilKapvay
Risk factors for serious side effects
ProvigilKapvay
  • Taking with alcohol
  • Taking other medicines that make you less alert
      • Current kidney problems
      • Current liver problems
      • History of heart problems
      • History of psychiatric disorder
      • History of bipolar disorder
      Detailed Provigil (Modafinil) risks & warnings »
      • Sudden discontinuation of medicine
      • Taking with alcohol
      • Taking other medicines that make you less alert
      • Age 65 years or older
      • Using other medicine(s) that slows the heart
        Detailed Kapvay (Clonidine) risks & warnings »
        Pregnancy category
        ProvigilKapvay
        CFDA pregnancy category (Weigh risks vs. benefits)

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        See the FDA package insert
        CFDA pregnancy category (Weigh risks vs. benefits)

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        See the FDA package insert
        Alcohol
        • Don't drink alcohol with Provigil (Modafinil).
        No specific alcohol-related info.
        Food
        No specific food-related info.No specific food-related info.
        Kidneys and liver
        • Not a good choice if you have liver or kidney problems.
        • Provigil (Modafinil) is broken down by the kidney and liver. If you have kidney or liver problems, you may need to use a lower dose to prevent more side effects.
        No specific kidneys and liver-related info.
        Sex
        No specific sex-related info.No specific sex-related info.
        Sleep
        • Effective in reducing excessive sleepiness in Shift-work Sleep Disorder.
        • Doesn't negatively affect daytime sleep.
        • Can cause drowsiness, headache, dizziness, and dry mouth.
        Weight
        No specific weight-related info.No specific weight-related info.
        Upsides and benefits
        ProvigilKapvay
        • It's a non-amphetamine medicine that helps improve alertness.
        • Available in a generic version.
        • Effective in reducing excessive sleepiness in Shift-work Sleep Disorder.
        • Doesn't negatively affect daytime sleep.
        • Can be used alone or together with a stimulant-type medicine to treat ADHD.
        • In studies, it improved attention span and lowered hyperactivity and impulsivity in children and adolescents ages 6 to 17.
        • Also treats blood pressure and some nervous system and psychiatric conditions.
        Downsides and risks
        ProvigilKapvay
        • Provigil (Modafinil) can be habit-forming, so it's typically not used for long-term treatment.
        • Interacts with many other medications.
        • Taking Provigil (Modafinil) will make hormonal birth control less effective. You should definitely use additional forms of non-hormonal contraception.
        • Not a good choice if you have liver or kidney problems.
        • Can lower blood pressure.
        • The pill form can make some people sleepy, dizzy, and have dry mouth.
        • You can't miss doses. Stopping Clonidine suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
        Tips from our pharmacists for people taking the medication
        ProvigilKapvay
        • Take Provigil (Modafinil) about an hour before you need to be fully alert.
        • Taking caffeine with Provigil (Modafinil) can cause you to feel nervous, shaky, and have a faster heartbeat. Try limiting your caffeine intake.
        • Until you know how Provigil (Modafinil) makes you feel, don't drive or perform any tasks that need you to be alert.
        • You can experience withdrawal symptoms if you suddenly stop taking Provigil (Modafinil). Talk to your doctor before making any changes.
        • Tell your doctor right away if you break out in a rash.
        • Don't drink alcohol with Provigil (Modafinil).
        • Can cause drowsiness, headache, dizziness, and dry mouth.
        • For ADHD: Might take up to 2 weeks to see effects.
        • For high blood pressure: Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
        • If side effects don't go away, talk to your doctor about alternatives.
        • Don't stop taking this medicine suddenly.
        Learn more
        More about ProvigilSide effectsReviews & ratingsAlternativesFDA package insert
        More about KapvaySide effectsReviews & ratingsAlternativesFDA package insert