Compare Provigil vs. Kapvay

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Provigil
(modafinil)

Kapvay
(clonidine)

Improves alertness. Provigil (Modafinil) is effective in improving alertness, but it can interact with other medicines and shouldn't be used long-term.Treats attention deficit hyperactivity disorder. Kapvay (clonidine) is one of the few medicines for ADHD that isn't a stimulant and not addictive, but it can lower your blood pressure.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.75Provigil
Reviews for Provigil
82%
of people (All ages) say Provigil is worth it
71%
say it works well
4%
say it's a big hassle
Have you used Provigil (modafinil)?
Worth itNot sureNot worth it

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Have you used Kapvay (clonidine)?
Worth itNot sureNot worth it
Side effects
ProvigilKapvay
  • Headache 11%
  • Nausea 8%
  • Any side effect 5%
  • Inflammation inside the nose 1%
  • Nervousness 4%
  • Back pain 1%
  • Diarrhea 1%
  • Dizziness 1%
  • Sleep difficulty 4%
  • Indigestion 1%
More Provigil side effects »
  • Sleepiness 34%
  • Headache 4%
  • Fatigue 15%
  • Upper abdominal pain 3%
  • Irritability 5%
  • Dizziness 2%
  • Sleep difficulty 4%
  • Emotional disorder 3%
  • Nightmare 4%
  • Nausea 1%
More Kapvay side effects »
How it works
ProvigilKapvay
Provigil (Modafinil) is a stimulant that helps you feel awake. Researchers don't know exactly how Provigil (Modafinil) works, but it probably affects chemicals (neurotransmitters) in the brain.Kapvay (clonidine) is an alpha-2 agonist. It's not entirely clear how it works for ADHD, but it lowers the activity of certain stress hormones in the brain.
Type of medication
ProvigilKapvay
Prescription onlyPrescription only
Available as
ProvigilKapvay
  • Pill
  • Extended release
Used for
ProvigilKapvay
Risk factors for serious side effects
ProvigilKapvay
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Current kidney problems
  • Current liver problems
  • History of heart problems
Detailed Provigil (modafinil) risks & warnings »
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Stopping Kapvay (clonidine) suddenly
Detailed Kapvay (clonidine) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
ProvigilKapvay
  • Interacts with many other medications.
No interactions related info.
Alcohol
ProvigilKapvay
  • Don't drink alcohol with Provigil (Modafinil).
No alcohol related info.
Kidneys and liver
ProvigilKapvay
  • Provigil (Modafinil) is broken down by the kidney and liver. If you have kidney or liver problems, you may need to use a lower dose to prevent more side effects.
  • Not a good choice if you have liver or kidney problems.
No kidneys and liver related info.
Sleep
ProvigilKapvay
No sleep related info.
  • People who take Kapvay (clonidine) can feel very sleepy during the day. It can be worse if you're taking other medicines that also make you sleepy, like pain medicines, or medicines for anxiety. Be very careful driving or doing anything that requires your full concentration until you know how your body reacts to it.
  • Can cause drowsiness, headache, dizziness, and dry mouth.
Upsides and benefits
ProvigilKapvay
  • It's a non-amphetamine medicine that helps improve alertness.
  • Available in a generic version.
  • Effective in reducing excessive sleepiness in Shift-work Sleep Disorder.
  • Doesn't negatively affect daytime sleep.
  • Can be used alone or together with a stimulant-type medicine to treat ADHD.
  • Also treats blood pressure and some nervous system and psychiatric conditions.
  • Kapvay (clonidine) is available in generic.
Downsides and risks
ProvigilKapvay
  • Provigil (Modafinil) can be habit-forming, so it's typically not used for long-term treatment.
  • Interacts with many other medications.
  • Taking Provigil (Modafinil) will make hormonal birth control less effective. You should definitely use additional forms of non-hormonal contraception.
  • Not a good choice if you have liver or kidney problems.
  • Kapvay (clonidine) is not a first choice medicine to treat ADHD.
  • Kapvay (clonidine) can make you feel very dizzy or cause low blood pressure.
  • Stopping Kapvay (clonidine) suddenly can cause your blood pressure to jump and your heart to beat very fast.
  • It can take up to two weeks of taking Kapvay (clonidine) to notice any changes in behavior.
  • Kapvay (clonidine) has to be swallowed whole, which can be hard for some children to do.
Tips from our pharmacists for people taking the medication
ProvigilKapvay
  • Take Provigil (Modafinil) about an hour before you need to be fully alert.
  • Taking caffeine with Provigil (Modafinil) can cause you to feel nervous, shaky, and have a faster heartbeat. Try limiting your caffeine intake.
  • Until you know how Provigil (Modafinil) makes you feel, don't drive or perform any tasks that need you to be alert.
  • You can experience withdrawal symptoms if you suddenly stop taking Provigil (Modafinil). Talk to your doctor before making any changes.
  • Tell your doctor right away if you break out in a rash.
  • Don't drink alcohol with Provigil (Modafinil).
  • Can cause drowsiness, headache, dizziness, and dry mouth.
  • You might have to take Kapvay (clonidine) for at least two weeks before you notice any changes.
  • Don't stop taking this medicine suddenly without talking to your doctor.
  • Swallow Kapvay (clonidine) whole. Don't chew, cut or crush the pill.
  • If you forget your daily dose of Kapvay (clonidine), skip it for that day. Don't double up the next day.
Learn more
More about ProvigilSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Provigil (modafinil)?
Worth itNot sureNot worth it
More about KapvaySide effectsReviews & ratingsAlternativesFDA package insert
Have you used Kapvay (clonidine)?
Worth itNot sureNot worth it