Compare Provigil vs. Strattera

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Provigil (modafinil)

Prescription only

Strattera (Atomoxetine)

Prescription only
Improves alertness.

Provigil (modafinil) is effective in improving alertness, but it interacts with some medicines and shouldn't be used long-term.

4.2/ 5 average rating with 28 reviewsforProvigil
Helps you focus and stay alert.

Strattera (Atomoxetine) isn't considered a first-line medication for ADHD, but since it isn't a stimulant, it's still highly recommended.

3.2/ 5 average rating with 94 reviewsforStrattera
Upsides
  • Provigil (modafinil) is a nonstimulant medication that improves alertness.
  • Provigil (modafinil) is available in a cheaper, generic version.
  • Provigil (modafinil) is good at decreasing excessive sleepiness in shift work sleep disorder.
  • If you need to sleep in the daytime, this medication won't effect you.
  • One of the few medications used to treat ADHD that's not a stimulant.
  • It isn't a controlled substance.
  • Strattera (Atomoxetine) is used in combination with counseling or other non-drug therapies to treat ADHD.
  • You usually only need to take it once a day.
Downsides
  • Provigil (modafinil) can be habit forming, so it shouldn't be used for long-term treatment.
  • Provigil (modafinil) is not a good choice if you have liver problems.
  • May not be a good option if you are taking hormonal contraception like birth control pills.
  • It's a second-line medication used to treat ADHD. Other medications are usually tried first.
  • It's only available as a brand name medication, so it can be expensive.
Used for
Dosage forms
  • Pill
  • Pill
Price
Want to save even more money?
Sign up now for a 30-day trial and save up to 95% at CVS, Kroger, Albertsons, and other pharmacies.
Reviews
28 reviews so far
82%
saidit'sworth it
71%
saiditworked well
4%
saidit'sa big hassle

Have you used Provigil (modafinil)?

Leave a review
94 reviews so far
46%
saidit'sworth it
32%
saiditworked well
24%
saidit'sa big hassle

Have you used Strattera (Atomoxetine)?

Leave a review
Side effects
25possible side effects
  • Headache
    34%
  • Nausea
    11%
  • Nervousness
    7%
  • Stuffy nose
    7%
  • Back pain
    6%
  • Diarrhea
    6%
  • Indigestion
    5%
  • Difficulty sleeping
    5%
  • Anxiety
    5%
  • Dizziness
    5%
  • Flu symptoms
    4%
  • Dry mouth
    4%
  • Loss of appetite
    4%
  • Throat inflammation
    4%
  • Chest pain
    3%
  • High blood pressure
    3%
  • Fast heart beat
    2%
  • Palpitation
    2%
  • Dilation of blood vessels
    2%
  • Constipation
    2%
  • Abnormal liver function
    2%
  • Depression
    2%
  • Burning/tingling sensation
    2%
  • Drowsiness
    2%
  • Lung disorder
    2%
See more detailed side effects
30possible side effects
  • Nausea
    26%
  • Dry mouth
    20%
  • Decreased appetite
    16%
  • Insomnia
    15%
  • Changes in heart rate or blood pressure
    10%
  • Fatigue
    10%
  • Constipation
    8%
  • Dizziness
    8%
  • Somnolence
    8%
  • Erectile dysfunction
    8%
  • Abdominal pain
    7%
  • Urinary hesitation
    6%
  • Irritability
    5%
  • Dyspepsia
    4%
  • Vomiting
    4%
  • Abnormal dreams
    4%
  • Ejaculation delayed and/or ejaculation disorder
    4%
  • Hyperhidrosis
    4%
  • Palpitations
    3%
  • Chills
    3%
  • Paraesthesia
    3%
  • Libido decreased
    3%
  • Sleep disorder
    3%
  • Dysmenhorrhea
    3%
  • Hot flush
    3%
  • Feeling jittery
    2%
  • Thirst
    2%
  • Weight loss
    2%
  • Dysuria
    2%
  • Any sexual side effect
    2%
See more detailed side effects
Risks and risk factors
  • Serious allergic reactions
    • Allergy to Provigil (modafinil)
  • Heart problems
    • History of heart problems
  • Increased side effects
    • Current kidney problems
    • Current liver problems
  • Driving impairment
    • Taking with alcohol or drugs
See more detailed risks and warnings
  • Suicidal thinking
    • Age below 18
  • Liver disease
  • Serious or life-threatening cardiovascular events
    • History of heart problems
  • Aggressive behavior and psychosis
    • History of psychotic episodes
    • History of Bipolar Disorder
  • Prolonged erection
  • Problems with urination
  • Long-term growth suppression
    • Starting Strattera (Atomoxetine) before puberty
See more detailed risks and warnings