Compare Provigil vs. Strattera

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Provigil
(Modafinil)

Strattera
(Atomoxetine)

Improves alertness. Provigil (Modafinil) is effective in improving alertness, but it can interact with other medicines and shouldn't be used long-term.Helps you focus and stay alert. Strattera (Atomoxetine) isn't considered a first-line medication for ADHD, but since it isn't a stimulant, it's still highly recommended.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.75Provigil
Reviews for Provigil
82%
of people (All ages) say Provigil is worth it
71%
say it works well
4%
say it's a big hassle
Have you used Provigil (Modafinil)?
Worth itNot sureNot worth it
Reviews for Strattera
46%
+36% better vs. Provigil
32%
+39% better vs. Provigil
24%
+20% better vs. Provigil
Have you used Strattera (Atomoxetine)?
Worth itNot sureNot worth it
Side effects
ProvigilStrattera
  • Headache 2%
  • Tachycardia 1%
  • Palpitation 1%
  • Vasodilation 2%
  • Constipation 1%
  • Abnormal Liver Function 1%
  • Depression 1%
  • Paresthesia 2%
  • Somnolence 1%
  • Lung Disorder 1%
More Provigil side effects »
  • Therapeutic response unexpected 1%
  • Rash 1%
  • Any side effect 2%
  • Weight loss 3%
  • Anorexia 2%
  • Dizziness 3%
  • Irritability 3%
  • Fatigue 5%
  • Changes in heart rate or blood pressure 10%
  • Nausea 5%
More Strattera side effects »
How it works
ProvigilStrattera
Provigil (Modafinil) is a stimulant that helps you feel awake. Researchers don't know exactly how Provigil (Modafinil) works, but it probably affects chemicals (neurotransmitters) in the brain.Strattera (Atomoxetine) is a norepinephrine reuptake inhibitor (non-stimulant). Researchers don't know exactly how it works for ADHD, but it increases norepinephrine activity in the brain, which affects attention and behavior.
Type of medication
ProvigilStrattera
Prescription onlyLower-cost generic availablePrescription onlyLower-cost generic available
Available as
ProvigilStrattera
  • Pill
  • Pill
Used for
ProvigilStrattera
Risk factors for serious side effects
ProvigilStrattera
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Current kidney problems
  • Current liver problems
  • History of heart problems
Detailed Provigil (Modafinil) risks & warnings »
  • Age below 18
  • History of heart problems
  • History of psychotic episodes
  • History of Bipolar Disorder
  • Starting Strattera (Atomoxetine) before puberty
Detailed Strattera (Atomoxetine) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
ProvigilStrattera
  • Interacts with many other medications.
No interactions related info.
Alcohol
ProvigilStrattera
  • Don't drink alcohol with Provigil (Modafinil).
No alcohol related info.
Kidneys and liver
ProvigilStrattera
  • Provigil (Modafinil) is broken down by the kidney and liver. If you have kidney or liver problems, you may need to use a lower dose to prevent more side effects.
  • Not a good choice if you have liver or kidney problems.
No kidneys and liver related info.
Upsides and benefits
ProvigilStrattera
  • It's a non-amphetamine medicine that helps improve alertness.
  • Available in a generic version.
  • Effective in reducing excessive sleepiness in Shift-work Sleep Disorder.
  • Doesn't negatively affect daytime sleep.
  • One of the few medications used to treat ADHD that's not a stimulant.
  • It isn't a controlled substance.
  • Strattera (Atomoxetine) is used in combination with counseling or other non-drug therapies to treat ADHD.
  • You usually only need to take it once a day.
Downsides and risks
ProvigilStrattera
  • Provigil (Modafinil) can be habit-forming, so it's typically not used for long-term treatment.
  • Interacts with many other medications.
  • Taking Provigil (Modafinil) will make hormonal birth control less effective. You should definitely use additional forms of non-hormonal contraception.
  • Not a good choice if you have liver or kidney problems.
  • It's a second-line medication used to treat ADHD. Other medications are usually tried first.
  • It's only available as a brand name medication, so it can be expensive.
Tips from our pharmacists for people taking the medication
ProvigilStrattera
  • Take Provigil (Modafinil) about an hour before you need to be fully alert.
  • Taking caffeine with Provigil (Modafinil) can cause you to feel nervous, shaky, and have a faster heartbeat. Try limiting your caffeine intake.
  • Until you know how Provigil (Modafinil) makes you feel, don't drive or perform any tasks that need you to be alert.
  • You can experience withdrawal symptoms if you suddenly stop taking Provigil (Modafinil). Talk to your doctor before making any changes.
  • Tell your doctor right away if you break out in a rash.
  • Don't drink alcohol with Provigil (Modafinil).
  • It can cause changes in sex drive.
  • Can raise your blood pressure and pulse, so it's not safe for people with heart problems.
  • It can also cause changes in your mood.
  • Take it at the same time every day.
  • Common side effects include decreased appetite, nausea, and constipation.
  • The capsules can't be opened and need to be swallowed whole.
Learn more
More about ProvigilSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Provigil (Modafinil)?
Worth itNot sureNot worth it
More about StratteraSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Strattera (Atomoxetine)?
Worth itNot sureNot worth it