Compare Prozac vs. Celexa

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Prozac
(fluoxetine)

Celexa
(citalopram)

Improves mood and helps you relax. Prozac (Fluoxetine) is good for treating depression and anxiety. It's more energizing than other antidepressants, but may not be the best choice for people who have trouble sleeping.Improves mood and helps you relax. Celexa (Citalopram) is good for treating depression and anxiety. Might be less likely to cause side effects than some antidepressants, but not the best choice for people with heart or liver problems.
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Prices and coupon for 30 (20mg) capsules of fluoxetine
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Prices and coupon for 30 (20mg) tablets of citalopram
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.74Prozac
Reviews for Prozac (fluoxetine)
62%
of people (All ages) say Prozac (fluoxetine) is worth it
40%
say it works well
16%
say it's a big hassle
1319 reviews
Have you used Prozac (fluoxetine)?
Worth itNot sureNot worth it
Reviews for Celexa (citalopram)
61%
-1% worse vs. Prozac (fluoxetine)
51%
+11% better vs. Prozac (fluoxetine)
16%
Same vs. Prozac (fluoxetine)
520 reviews
Have you used Celexa (citalopram)?
Worth itNot sureNot worth it
Side effects
ProzacCelexa
  • Nausea 13%
  • Headache 2%
  • Sleep difficulty 18%
  • Nervousness 5%
  • Drowsiness 7%
  • Anxiety 6%
  • Diarrhea 4%
  • Muscle weakness 5%
  • Loss of appetite 7%
  • Dizziness 3%
More Prozac side effects »
  • Nausea 7%
  • Dry mouth 6%
  • Drowsiness 8%
  • Sleep difficulty 1%
  • Sweating increased 2%
  • Diarrhea 3%
  • Tremor 2%
  • Ejaculation disorder 5%
  • Inflammation inside the nose 1%
  • Indigestion 1%
More Celexa side effects »
How it works
ProzacCelexa
Prozac (Fluoxetine) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.Celexa (Citalopram) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.
Type of medication
ProzacCelexa
Prescription only
Prescription only
Available as
ProzacCelexa
  • Pill
  • Delayed release capsule
  • Liquid
  • Pill
  • Oral solution
Used for
ProzacCelexa
Risk factors for serious side effects
ProzacCelexa
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • Stopping Prozac (Fluoxetine) suddenly
  • History of heart problems
  • History of liver problems
  • Drug interactions
  • Taking other blood-thinning drugs
    • History of bipolar disorder
    • At risk for bipolar disorder
    Detailed Prozac (fluoxetine) risks & warnings »
    • Age 24 years or younger
    • Using other medications that affect serotonin
    • History of bipolar disorder
    • At risk for bipolar disorder
    • Stopping Celexa (Citalopram) suddenly
    • Higher dose
    • History of heart problems
    • History of liver problems
    • Older age
    • Taking other blood-thinning drugs
      Detailed Celexa (citalopram) risks & warnings »
      Pregnancy

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Food
      ProzacCelexa
      • Take in the morning with food to avoid side effects.
      • Take with food to avoid upset stomach.
      Kidneys and liver
      ProzacCelexa
      No kidneys and liver related info.
      • Not a good option for you if you have heart or liver problems.
      Sex
      ProzacCelexa
      • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
      • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
      Weight
      ProzacCelexa
      No weight related info.
      • Can cause minor weight gain (1 to 5 pounds).
      Upsides and benefits
      ProzacCelexa
      • Effective at relieving depression and anxiety symptoms.
      • Lowers relapse rates of depression and bulimia nervosa.
      • Causes less sleepiness than other antidepressants.
      • It's more energizing than other antidepressants, so it's good for people who have low energy.
      • It has been used to treat depression for a long time, so there's a lot of information available about how it works and how safe it is.
      • Six out of ten people who use an antidepressant for the first time find that it works for them.
      • Effective at relieving depression and anxiety symptoms.
      • Causes less sleepiness compared to other antidepressants.
      • Six out of ten people who use an antidepressant for the first time find that it works for them.
      Downsides and risks
      ProzacCelexa
      • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
      • Can increase feelings of anxiety or cause headaches during the first few weeks of taking it. These effects should go away over time.
      • More likely than other antidepressants to interact with other medications you're taking.
      • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
      • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
      • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
      • Can cause minor weight gain (1 to 5 pounds).
      • Celexa (Citalopram) can cause an irregular heartbeat if you take a high dose (40 mg a day, or more).
      • Not a good option for you if you have heart or liver problems.
      • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24 years.
      • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
      Tips from our pharmacists for people taking the medication
      ProzacCelexa
      • Take in the morning with food to avoid side effects.
      • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
      • Stop taking it slowly to avoid getting withdrawal symptoms.
      • Tell your doctor if you notice sudden mood changes or unusual thoughts.
      • Take with food to avoid upset stomach.
      • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
      • Stop taking it slowly to avoid getting withdrawal symptoms.
      • Tell your doctor if you notice sudden mood changes or unusual thoughts.
      Learn more
      More about ProzacSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Prozac (fluoxetine)?
      Worth itNot sureNot worth it
      More about CelexaSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Celexa (citalopram)?
      Worth itNot sureNot worth it