Compare Prozac vs. Klonopin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Prozac
(fluoxetine)

Klonopin
(clonazepam)

Improves mood and helps you relax. Prozac (Fluoxetine) is good for treating depression and anxiety. It's more energizing than other antidepressants, but may not be the best choice for people who have trouble sleeping.Controls seizures and helps you relax. Klonopin (Clonazepam) is okay for occasional or short-term use (up to 4 weeks) for anxiety, and to treat seizures. Less severe withdrawal symptoms compared to similar drugs.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.74Prozac
Reviews for Prozac
62%
of people (All ages) say Prozac is worth it
40%
say it works well
16%
say it's a big hassle
1319 reviews
Have you used Prozac (fluoxetine)?
Worth itNot sureNot worth it
Reviews for Klonopin
70%
-8% worse vs. Prozac
52%
-12% worse vs. Prozac
14%
-2% worse vs. Prozac
767 reviews
Have you used Klonopin (clonazepam)?
Worth itNot sureNot worth it
Side effects
ProzacKlonopin
  • Nausea 13%
  • Headache 2%
  • Sleep difficulty 18%
  • Nervousness 5%
  • Drowsiness 7%
  • Anxiety 6%
  • Diarrhea 4%
  • Muscle weakness 5%
  • Loss of appetite 7%
  • Dizziness 3%
More Prozac side effects »
  • Drowsiness 50%
  • Lack of muscle coordination 30%
  • Behavior problems 25%
  • Ear, nose, or throat infection 6%
  • Fatigue 5%
  • Low mood disorder 6%
  • Dizziness 1%
  • Vaginal inflammation 3%
  • Sinus inflammation 1%
  • Inflammation inside the nose 2%
More Klonopin side effects »
How it works
ProzacKlonopin
Prozac (Fluoxetine) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.Klonopin (Clonazepam) is a fast-acting benzodiazepine. It affects neurotransmitters in the brain and calms the nervous system. This reduces anxiety and muscle spasms, and causes sleepiness.
Type of medication
ProzacKlonopin
Prescription onlyPrescription only
Available as
ProzacKlonopin
  • Pill
  • Delayed release capsule
  • Liquid
  • Pill
  • Dissolving tablet
Used for
ProzacKlonopin
Risk factors for serious side effects
ProzacKlonopin
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • Stopping Prozac (Fluoxetine) suddenly
  • History of heart problems
  • History of liver problems
Detailed Prozac (fluoxetine) risks & warnings »
  • Taking more than the prescribed dose
  • Taking longer than 4 weeks
  • History of drug abuse
  • Long-term use
  • Alcohol
Detailed Klonopin (clonazepam) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
ProzacKlonopin
No alcohol related info.
  • Not safe to use with alcohol.
  • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
Food
ProzacKlonopin
  • Take in the morning with food to avoid side effects.
No food related info.
Sex
ProzacKlonopin
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
No sex related info.
Sleep
ProzacKlonopin
No sleep related info.
  • Can cause dizziness, drowsiness, and salivation.
  • Can cause memory problems, drowsiness, dizziness, and confusion.
Upsides and benefits
ProzacKlonopin
  • Effective at relieving depression and anxiety symptoms.
  • Lowers relapse rates of depression and bulimia nervosa.
  • Causes less sleepiness than other antidepressants.
  • It's more energizing than other antidepressants, so it's good for people who have low energy.
  • It has been used to treat depression for a long time, so there's a lot of information available about how it works and how safe it is.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
  • Effective at relieving short-term anxiety and sleeplessness.
  • Can be used together with antidepressants to manage anxiety disorders. Especially helpful for anxiety symptoms while you wait for an antidepressant to kick in (it can take several weeks).
  • Can be used alone or with other medicines to treat seizures.
  • Less severe withdrawal symptoms compared to other benzodiazepines.
Downsides and risks
ProzacKlonopin
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
  • Can increase feelings of anxiety or cause headaches during the first few weeks of taking it. These effects should go away over time.
  • More likely than other antidepressants to interact with other medications you're taking.
  • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
  • Can cause memory problems, drowsiness, dizziness, and confusion.
  • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
  • Most people find that it gets less effective over time.
Tips from our pharmacists for people taking the medication
ProzacKlonopin
  • Take in the morning with food to avoid side effects.
  • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
  • Stop taking it slowly to avoid getting withdrawal symptoms.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
  • For the first week, avoid activities that require you to be alert.
  • Can cause dizziness, drowsiness, and salivation.
  • Report any confusion or inability to control muscle movements to your doctor.
  • Not safe to use with alcohol.
Learn more
More about ProzacSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Prozac (fluoxetine)?
Worth itNot sureNot worth it
More about KlonopinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Klonopin (clonazepam)?
Worth itNot sureNot worth it