Compare Prozac vs. Pristiq

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Prozac (fluoxetine)

Prescription only

Pristiq (Desvenlafaxine)

Prescription only
Improves mood and helps you relax.

Prozac (fluoxetine) is good for treating depression and anxiety. It's more energizing than other antidepressants, so it may not be the best choice for people who have trouble sleeping.

3.5/ 5 average rating with 1319 reviewsforProzac
Improves mood.

Pristiq (Desvenlafaxine) is basically the same medication as Effexor, which is cheaper because it's available as a generic.

3.5/ 5 average rating with 196 reviewsforPristiq
Upsides
  • Effectively treats a variety of mental health conditions such as depression, OCD, and panic disorder.
  • It's more energizing than other antidepressants, so it's good for people who have low energy.
  • Might be a good option for treating children with depression and/or OCD.
  • Doesn't have effects on the heart unlike other antidepressants so it may be a better treatment choice for older people.
  • Can cause a significant amount of weight loss which is an added benefit for those who are overweight or obese.
  • Effective at relieving symptoms and lowering relapse rates for depression.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
Downsides
  • Takes at least 1 to 2 weeks to kick in and can take up to 12 weeks for maximum effect. Prozac (fluoxetine) tends to take more time to start working compared to similar alternatives.
  • Can lower your sex drive.
  • Can increase the risk of suicidal thoughts and/or behavior in those age 24 or younger.
  • You may need to try out several different antidepressants before you find the one that works for you.
  • Similar to Effexor, without any extra benefits in clinical studies.
  • Can cause sexual side effects (usually low libido or the inability to have an orgasm or ejaculate).
  • Not available in generic form, so it's more expensive.
  • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
Used for
Dosage forms
  • Pill
  • Delayed-release pill
  • Liquid
  • Extended release
Price
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Reviews
1319 reviews so far
62%
saidit'sworth it
40%
saiditworked well
16%
saidit'sa big hassle

Have you used Prozac (fluoxetine)?

Leave a review
196 reviews so far
53%
saidit'sworth it
49%
saiditworked well
23%
saidit'sa big hassle

Have you used Pristiq (Desvenlafaxine)?

Leave a review
Side effects
22possible side effects
  • Inability to sleep
    33%
  • Nausea
    28%
  • Lack of energy
    21%
  • Anxiety
    15%
  • Sleepiness
    13%
  • Tremor
    13%
  • Nervousness
    11%
  • Yawn
    11%
  • Indigestion
    10%
  • Sore throat
    10%
  • Dry mouth
    9%
  • Flu syndrome
    8%
  • Diarrhea
    8%
  • Loss of appetite
    8%
  • Sweating
    8%
  • Impotence
    7%
  • Abnormal ejaculation
    7%
  • Sinus infection
    6%
  • Lower sex drive
    5%
  • Abnormal dreams
    5%
  • Rash
    4%
  • Widening of blood vessels
    2%
See more detailed side effects
17possible side effects
  • Nausea
    22%
  • Dizziness
    13%
  • Dry mouth
    11%
  • Hyperhidrosis
    10%
  • Constipation
    9%
  • Insomnia
    9%
  • Fatigue
    7%
  • Decreased appetite
    5%
  • Somnolence
    4%
  • Vomiting
    3%
  • Anxiety
    3%
  • Vision blurred
    3%
  • Tremor
    2%
  • Abnormal dreams
    2%
  • Mydriasis
    2%
  • Vertigo
    2%
  • Tinnitus
    2%
See more detailed side effects
Risks and risk factors
  • Suicidal thoughts or behavior
    • Age 24 or younger
  • Serotonin syndrome
    • Antidepressants
    • Lithium
    • Ultram
    • Imitrex
    • Remeron
    • Lexapro
    • Dilaudid
    • St. John's Wort
  • Skin rash
  • Weight loss
    • People with an eating disorder
  • Increased bleeding risk
    • Taking NSAIDS or blood-thinning drugs
  • Abnormal heart rhythm
    • People with heart rhythm problems or a family history of them
    • Low potassium level
    • Low magnesium level
    • Recent heart attack
    • Using other drugs that affect heart rhythm
    • Overdose
    • People with liver problems
See more detailed risks and warnings
  • Suicidal thoughts or behavior
    • Age 24 years or younger
  • Serotonin syndrome
    • Using other medications that affect serotonin
  • Withdrawal
    • Stopping Pristiq (Desvenlafaxine) suddenly
  • High blood pressure
    • History of high blood pressure
  • Increased bleeding
    • Taking other blood-thinning drugs
  • Sexual dysfunction
  • Mania
    • History of bipolar disorder
    • At risk for bipolar disorder
See more detailed risks and warnings