Compare Prozac vs. Remeron

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Prozac
(Fluoxetine)

Remeron
(Mirtazapine)

Improves mood and helps you relax. Prozac (Fluoxetine) is good for treating depression and anxiety. It's more energizing than other antidepressants, but may not be the best choice for people who have trouble sleeping.Improves mood. Remeron (Mirtazapine) is okay for treating depression and good for sleep. More likely to cause weight gain than any other antidepressant.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.7375Prozac
Reviews for Prozac (Fluoxetine)
61%
of people (All ages) say Prozac (Fluoxetine) is worth it
40%
say it works well
16%
say it's a big hassle
1200 reviews
Have you used Prozac (Fluoxetine)?
Worth itNot sureNot worth it
Reviews for Remeron (Mirtazapine)
47%
14% vs. Prozac (Fluoxetine)
42%
+2% vs. Prozac (Fluoxetine)
26%
10% vs. Prozac (Fluoxetine)
127 reviews
Have you used Remeron (Mirtazapine)?
Worth itNot sureNot worth it
Side effects
ProzacRemeron
  • Rash 57%
  • Sleep difficulty 20%
  • Nausea 18%
  • Muscle weakness 12%
  • Drowsiness 10%
  • Tremor 9%
  • Dry mouth 9%
  • Lower sex drive 9%
  • Loss of appetite 7%
  • Anxiety 7%
More Prozac side effects »
  • Drowsiness 36%
  • Increased appetite 15%
  • Dry mouth 10%
  • Weight gain 10%
  • Constipation 6%
  • Dizziness 4%
  • Muscle weakness 3%
  • Abnormal dreams 3%
  • Flu syndrome 2%
  • Thinking abnormal 2%
More Remeron side effects »
How it works
ProzacRemeron
Prozac (Fluoxetine) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.Remeron (Mirtazapine) is an atypical antidepressant. It stimulates your body to make certain chemicals in the brain, such as serotonin and norepinephrine, which regulate mood.
Type of medication
ProzacRemeron
Antidepressant
Selective serotonin reuptake inhibitor (SSRI)
Prescription only
Antidepressant
Noradrenergic and specific serotonergic antidepressant
Prescription only
Available as
ProzacRemeron
  • Pill
  • Delayed release capsule
  • Liquid
  • Pill
  • Dissolving tablet
Used for (click to learn more)
ProzacRemeron
Risk factors for serious side effects
ProzacRemeron
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • Stopping Prozac (Fluoxetine) suddenly
  • History of heart problems
  • History of liver problems
  • Drug interactions
  • Taking other blood-thinning drugs
    • History of bipolar disorder
    • At risk for bipolar disorder
    Detailed Prozac (Fluoxetine) risks & warnings »
    • Age 24 years or younger
    • Using other medications that affect serotonin
    • History of heart problems
    • History of liver problems
    • Higher dose
    • Alcohol
    • Taking other medicines that make you less alert
        Detailed Remeron (Mirtazapine) risks & warnings »
        Pregnancy

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Food
        ProzacRemeron
        • Take in the morning with food to avoid side effects.
        No food related info.
        Sex
        ProzacRemeron
        • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
        No sex related info.
        Weight
        ProzacRemeron
        No weight related info.
        • More likely to cause minor weight gain (1 to 5 pounds) and raise cholesterol than any other antidepressant.
        • Can increase appetite and weight.
        • Remeron (Mirtazapine) can increase appetite and cause you to gain weight.
        Upsides and benefits
        ProzacRemeron
        • Effective at relieving depression and anxiety symptoms.
        • Lowers relapse rates of depression and bulimia nervosa.
        • Causes less sleepiness than other antidepressants.
        • It's more energizing than other antidepressants, so it's good for people who have low energy.
        • It has been used to treat depression for a long time, so there's a lot of information available about how it works and how safe it is.
        • Six out of ten people who use an antidepressant for the first time find that it works for them.
        • Effective at relieving some depression symptoms.
        • Starts to work more quickly than most antidepressants.
        • Might be a good option for people who have insomnia with their depression, because it can make you very sleepy.
        • Good option for people who are underweight or frail, because it can help you gain weight.
        • Six out of ten people who use an antidepressant for the first time find that it works for them.
        Downsides and risks
        ProzacRemeron
        • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
        • Can increase feelings of anxiety or cause headaches during the first few weeks of taking it. These effects should go away over time.
        • More likely than other antidepressants to interact with other medications you're taking.
        • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
        • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
        • Not as effective as other medications for depression.
        • More sedating than other antidepressants.
        • More likely to cause minor weight gain (1 to 5 pounds) and raise cholesterol than any other antidepressant.
        • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
        • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
        Tips from our pharmacists for people taking the medication
        ProzacRemeron
        • Take in the morning with food to avoid side effects.
        • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
        • Stop taking it slowly to avoid getting withdrawal symptoms.
        • Tell your doctor if you notice sudden mood changes or unusual thoughts.
        • Makes you sleepy. Take at bedtime.
        • Can increase appetite and weight.
        • Takes 8 to 12 weeks to see full effects on mood.
        • Stop taking slowly to avoid withdrawal symptoms.
        • Tell your doctor if you notice sudden mood changes or unusual thoughts.
        Learn more
        More about ProzacSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Prozac (Fluoxetine)?
        Worth itNot sureNot worth it
        More about RemeronSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Remeron (Mirtazapine)?
        Worth itNot sureNot worth it