Compare Prozac vs. Valium

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Prozac
(fluoxetine)

Valium
(diazepam)

Improves mood and helps you relax. Prozac (Fluoxetine) is good for treating depression and anxiety. It's more energizing than other antidepressants, but may not be the best choice for people who have trouble sleeping.Helps you relax. Valium (Diazepam) is okay for occasional or short-term use (up to 4 weeks) for anxiety and for pain and sleeplessness from muscle spasm. Less severe withdrawal symptoms compared to similar drugs.
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Reviews & ratings
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4.74Prozac
Reviews for Prozac (fluoxetine)
62%
of people (All ages) say Prozac (fluoxetine) is worth it
40%
say it works well
16%
say it's a big hassle
1319 reviews
Have you used Prozac (fluoxetine)?
Worth itNot sureNot worth it
Reviews for Valium (diazepam)
70%
+8% better vs. Prozac (fluoxetine)
53%
+13% better vs. Prozac (fluoxetine)
15%
+1% better vs. Prozac (fluoxetine)
976 reviews
Have you used Valium (diazepam)?
Worth itNot sureNot worth it
Side effects
ProzacValium
  • Nausea 13%
  • Headache 2%
  • Sleep difficulty 18%
  • Nervousness 5%
  • Drowsiness 7%
  • Anxiety 6%
  • Diarrhea 4%
  • Muscle weakness 5%
  • Loss of appetite 7%
  • Dizziness 3%
More Prozac side effects »

The Valium FDA package insert doesn’t have numbers about how common side effects are.

More about Valium side effects »
How it works
ProzacValium
Prozac (Fluoxetine) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.Valium (Diazepam) is a fast-acting benzodiazepine. It affects neurotransmitters in the brain and calms the nervous system. This reduces anxiety and muscle spasms, and causes sleepiness.
Type of medication
ProzacValium
Prescription only
Prescription only
Available as
ProzacValium
  • Pill
  • Delayed release capsule
  • Liquid
  • Pill
  • Liquid
  • Rectal gel
Used for
ProzacValium
Risk factors for serious side effects
ProzacValium
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • Stopping Prozac (Fluoxetine) suddenly
  • History of heart problems
  • History of liver problems
  • Drug interactions
  • Taking other blood-thinning drugs
    • History of bipolar disorder
    • At risk for bipolar disorder
    Detailed Prozac (fluoxetine) risks & warnings »
    • Taking more than the prescribed dose
    • Taking longer than 4 weeks
    • History of drug abuse
    • Long-term use
      • Alcohol
      • Taking other medicines that make you less alert
        • Current liver problems
        Detailed Valium (diazepam) risks & warnings »
        Pregnancy

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Alcohol
        ProzacValium
        No alcohol related info.
        • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
        • Not safe to use with alcohol.
        Food
        ProzacValium
        • Take in the morning with food to avoid side effects.
        No food related info.
        Kidneys and liver
        ProzacValium
        No kidneys and liver related info.
        • Processed by the liver, so might not be the best choice if you have liver problems.
        Sex
        ProzacValium
        • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
        No sex related info.
        Sleep
        ProzacValium
        No sleep related info.
        • Can cause memory problems, drowsiness, dizziness, and confusion.
        • Can cause temporary dizziness and drowsiness.
        Upsides and benefits
        ProzacValium
        • Effective at relieving depression and anxiety symptoms.
        • Lowers relapse rates of depression and bulimia nervosa.
        • Causes less sleepiness than other antidepressants.
        • It's more energizing than other antidepressants, so it's good for people who have low energy.
        • It has been used to treat depression for a long time, so there's a lot of information available about how it works and how safe it is.
        • Six out of ten people who use an antidepressant for the first time find that it works for them.
        • Effective at relieving short-term anxiety and sleeplessness.
        • Can be used together with antidepressants to manage anxiety disorders. Especially helpful for anxiety symptoms while you wait for an antidepressant to kick in (it can take several weeks).
        • Effective at relieving muscle spasms caused by a variety of conditions.
        • Less severe withdrawal symptoms compared to other benzodiazepines.
        Downsides and risks
        ProzacValium
        • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
        • Can increase feelings of anxiety or cause headaches during the first few weeks of taking it. These effects should go away over time.
        • More likely than other antidepressants to interact with other medications you're taking.
        • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
        • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
        • Processed by the liver, so might not be the best choice if you have liver problems.
        • Can cause memory problems, drowsiness, dizziness, and confusion.
        • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
        • Most people find that it gets less effective over time.
        Tips from our pharmacists for people taking the medication
        ProzacValium
        • Take in the morning with food to avoid side effects.
        • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
        • Stop taking it slowly to avoid getting withdrawal symptoms.
        • Tell your doctor if you notice sudden mood changes or unusual thoughts.
        • Good for short-term relief of anxiety symptoms.
        • Starts working in 30 minutes when swallowed.
        • Helpful with muscle spasms.
        • Can cause temporary dizziness and drowsiness.
        • Addictive. Long-term use can cause dependence or abuse.
        • Not safe to use with alcohol.
        Learn more
        More about ProzacSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Prozac (fluoxetine)?
        Worth itNot sureNot worth it
        More about ValiumSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Valium (diazepam)?
        Worth itNot sureNot worth it