Compare Prozac vs. Valium

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Prozac (Fluoxetine)

Prescription only

Valium (diazepam)

Prescription only
Improves mood and helps you relax.

Prozac (Fluoxetine) is good for treating depression and anxiety. It's more energizing than other antidepressants, but may not be the best choice for people who have trouble sleeping.

4.7/ 7 average rating with 1319 reviewsforProzac
Helps you relax.

Valium (diazepam) is effective for occasional or short-term use for anxiety and muscle spasm. Compared to similar drugs, Valium (diazepam) acts very quickly but can have interactions with other medicines.

5.2/ 7 average rating with 976 reviewsforValium
Upsides
  • Effective at relieving depression and anxiety symptoms.
  • Lowers relapse rates of depression and bulimia nervosa.
  • Causes less sleepiness than other antidepressants.
  • It's more energizing than other antidepressants, so it's good for people who have low energy.
  • It has been used to treat depression for a long time, so there's a lot of information available about how it works and how safe it is.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
  • Valium (diazepam) effectively relieves anxiety and muscle spasms.
  • Valium (diazepam) has less severe withdrawal symptoms compared to other similar drugs.
  • Works very quickly.
  • Available in generic.
Downsides
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
  • Can increase feelings of anxiety or cause headaches during the first few weeks of taking it. These effects should go away over time.
  • More likely than other antidepressants to interact with other medications you're taking.
  • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
  • Use of Valium (diazepam) can cause memory problems, drowsiness, dizziness, and confusion.
  • Valium (diazepam) can be habit-forming, so it's not typically used for long-term treatment.
  • Most people find that their body will get used to Valium (diazepam) levels and they may need higher doses over time to achieve the same effect.
  • People with severe liver problems should not take Valium (diazepam). Several drugs can also interfere with how Valium (diazepam) works.
Used for
Dosage forms
  • Pill
  • Delayed release capsule
  • Liquid
  • Pill
  • Liquid
Price
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$4
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$6.58
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Reviews
1319 
62%
think this treatment is worth it
40%
think this treatment works well
16%
think this treatment is a hassle

Have you used Prozac (Fluoxetine)?

Leave a review
976 
70%
think this treatment is worth it
53%
think this treatment works well
15%
think this treatment is a hassle

Have you used Valium (diazepam)?

Leave a review
Side effects
1possible side effects
  • Decreased libido
    4%
See more detailed side effects
The Valium (diazepam) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Suicidal thoughts or behavior

    Age 24 years or younger

  • Serotonin syndrome

    Using other medications that affect serotonin

  • Withdrawal

    Stopping Prozac (Fluoxetine) suddenly

  • Heart problems

    History of heart problems

    ...and 2 more risk factors

  • Increased bleeding

    Taking other blood-thinning drugs

  • Mania

    History of bipolar disorder

    ...and 1 more risk factors

See more detailed risks and warnings
  • Decreased breathing from use with opioids

    Taking Valium (diazepam) with opioids, drugs or alcohol

    ...and 1 more risk factors

  • Dependence and withdrawal

    History of substance abuse

    ...and 4 more risk factors

  • Driving impairment

    Alcohol use with Valium (diazepam)

    ...and 1 more risk factors

  • Drug interactions

    Current liver problems

    ...and 1 more risk factors

See more detailed risks and warnings