Compare Prozac vs. Viibryd

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Prozac
(Fluoxetine)

Viibryd
(Vilazodone)

Improves mood and helps you relax. Prozac (Fluoxetine) is good for treating depression and anxiety. It's more energizing than other antidepressants, but may not be the best choice for people who have trouble sleeping.Treats depression. Viibryd (Vilazodone) is a good option to treat depression, but it often causes stomach and intestinal problems, including diarrhea.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.7375Prozac
Reviews for Prozac (Fluoxetine)
61%
of people say Prozac (Fluoxetine) is worth it
40%
say it works well
16%
say it's a big hassle
Reviews for Viibryd (Vilazodone)
67%
+6% vs. Prozac (Fluoxetine)
59%
+19% vs. Prozac (Fluoxetine)
13%
+3% vs. Prozac (Fluoxetine)
Side effects
ProzacViibryd
  • Rash 57%
  • Sleep difficulty 20%
  • Nausea 18%
  • Muscle weakness 12%
  • Drowsiness 10%
  • Tremor 9%
  • Dry mouth 9%
  • Lower sex drive 9%
  • Loss of appetite 7%
  • Anxiety 7%
More Prozac side effects »
  • Diarrhea 19%
  • Nausea 18%
  • Vomiting 4%
  • Dizziness 4%
  • Sleep difficulty 4%
  • Dry mouth 3%
  • Abnormal dreams 3%
  • Tingling sensation 2%
  • Fatigue 1%
  • Impotence 1%
More Viibryd side effects »
How it works
ProzacViibryd
Prozac (Fluoxetine) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.Viibryd (Vilazodone) is an antidepressant that is both a selective serotonin reuptake inhibitor (SSRI) and a serotonin receptor agonist. It treats depression by adjusting the levels of serotonin in your brain.
Type of medication
ProzacViibryd
Antidepressant
Selective serotonin reuptake inhibitor (SSRI)
Prescription only
Antidepressant
Partial serotonin receptor agonist
Prescription only
Available as
ProzacViibryd
  • Pill
  • Delayed release capsule
  • Liquid
  • Pill
Used for (click to learn more)
ProzacViibryd
How well it works for depression
The free Iodine Start program helps people track how well they are improving, and find the right antidepressant faster.

After 4 weeks using Start and Prozac (Fluoxetine), here’s how much better people feel.

The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Viibryd (Vilazodone)
Risk factors for serious side effects
ProzacViibryd
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • Stopping Prozac (Fluoxetine) suddenly
  • History of heart problems
  • History of liver problems
  • Drug interactions
  • Taking other blood-thinning drugs
    • History of bipolar disorder
    • At risk for bipolar disorder
    Detailed Prozac (Fluoxetine) risks & warnings »
    • Age 18 years or younger
    • Taking Viibryd (Vilazodone) with MAOIs
    • Taking Viibryd (Vilazodone) with Zyvox or methylene blue
    • Taking Viibryd (Vilazodone) with other drugs that increase serotonin
    • Taking Viibryd (Vilazodone) with NSAIDs, warfarin, aspirin, or other drugs that affect clotting
    • Women of childbearing age
    • History of glaucoma
    • History of bipolar disorder (mixed/mania)
    Detailed Viibryd (Vilazodone) risks & warnings »
    Pregnancy category
    ProzacViibryd
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    Alcohol
    No specific alcohol-related info.
    • Need to avoid drinking alcohol while taking Viibryd (Vilazodone).
    Food
    • Take in the morning with food to avoid side effects.
    • Take Viibryd (Vilazodone) with food at the same time every day.
    Kidneys and liver
    No specific kidneys and liver-related info.
    • The dose of Viibryd (Vilazodone) doesn’t need to be changed if you have severe kidney disease.
    Sex
    • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
    • Prozac (Fluoxetine) can cause lower sex drive or difficulty having an orgasm. If the problem persists after the first 2 to 3 months, you can talk to your doctor about alternative antidepressants or performance-enhancing medications.
    • Compared to other antidepressants, it has a lower risk of weight gain and causing problems with sexual function.
    Sleep
    • Stopping Prozac (Fluoxetine) suddenly may cause withdrawal symptoms such as nausea, anxiety, agitation, flu-like symptoms, trouble sleeping, and dizziness. Withdrawal symptoms usually occur within 3 days of stopping the medication, and go away within 1 to 2 weeks. Work with your doctor to gradually reduce your dose.
    • In some people, antidepressants like Viibryd (Vilazodone) can trigger a manic episode (increased energy, severe trouble sleeping, racing thoughts, reckless behavior, unusually grand ideas, excessive happiness/ irritability, talking faster or louder than usual). Let your doctor know if you've had any manic episodes in the past or were treated for bipolar disorder before taking Viibryd (Vilazodone).
    Weight
    No specific weight-related info.
    • Compared to other antidepressants, it has a lower risk of weight gain and causing problems with sexual function.
    Upsides and benefits
    ProzacViibryd
    • Effective at relieving depression and anxiety symptoms.
    • Lowers relapse rates of depression and bulimia nervosa.
    • Causes less sleepiness than other antidepressants.
    • It's more energizing than other antidepressants, so it's good for people who have low energy.
    • It has been used to treat depression for a long time, so there's a lot of information available about how it works and how safe it is.
    • Six out of ten people who use an antidepressant for the first time find that it works for them.
    • Viibryd (Vilazodone) improves depressive symptoms in people with major depressive disorder.
    • The dose of Viibryd (Vilazodone) doesn’t need to be changed if you have severe kidney disease.
    • Compared to other antidepressants, it has a lower risk of weight gain and causing problems with sexual function.
    Downsides and risks
    ProzacViibryd
    • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
    • Can increase feelings of anxiety or cause headaches during the first few weeks of taking it. These effects should go away over time.
    • More likely than other antidepressants to interact with other medications you're taking.
    • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
    • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
    • You shouldn’t take Viibryd (Vilazodone) if you have severe liver problems.
    • Can’t take Viibryd (Vilazodone) with drugs called monoamine oxidase inhibitors (MAOIs).
    • Need to avoid drinking alcohol while taking Viibryd (Vilazodone).
    Tips from our pharmacists for people taking the medication
    ProzacViibryd
    • Take in the morning with food to avoid side effects.
    • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
    • Stop taking it slowly to avoid getting withdrawal symptoms.
    • Tell your doctor if you notice sudden mood changes or unusual thoughts.
    • Take Viibryd (Vilazodone) with food at the same time every day.
    • Your dose will need to be increased slowly over the first 3 weeks to reduce feelings of upset stomach.
    • It can take 4 to 6 weeks to see the full effects, so continue taking it even if you start to feel better.
    • Stopping Viibryd (Vilazodone) suddenly can cause withdrawal symptoms, including anxiety, irritability, headache, and dizziness. Gradually lower your dose over a 1 to 2 week period before stopping it completely.
    • Call your doctor right away if you notice new or worsening symptoms of aggressive or violent behavior, panic attacks, or other unusual changes in behavior or mood.
    Learn more
    More about ProzacSide effectsReviews & ratingsAlternativesFDA package insert
    More about ViibrydSide effectsReviews & ratingsAlternativesFDA package insert