Compare Prozac vs. Viibryd

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Prozac (Fluoxetine)

Prescription only

Viibryd (Vilazodone)

Prescription only
Improves mood and helps you relax.

Prozac (Fluoxetine) is good for treating depression and anxiety. It's more energizing than other antidepressants, but may not be the best choice for people who have trouble sleeping.

4.7/ 7 average rating with 1319 reviewsforProzac
Treats depression.

Viibryd (Vilazodone) is a good option to treat depression, but it often causes stomach and intestinal problems, including diarrhea.

5.4/ 7 average rating with 95 reviewsforViibryd
Upsides
  • Effective at relieving depression and anxiety symptoms.
  • Lowers relapse rates of depression and bulimia nervosa.
  • Causes less sleepiness than other antidepressants.
  • It's more energizing than other antidepressants, so it's good for people who have low energy.
  • It has been used to treat depression for a long time, so there's a lot of information available about how it works and how safe it is.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
  • Viibryd (Vilazodone) improves depressive symptoms in people with major depressive disorder.
  • The dose of Viibryd (Vilazodone) doesn’t need to be changed if you have severe kidney disease.
  • Compared to other antidepressants, it has a lower risk of weight gain and causing problems with sexual function.
Downsides
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
  • Can increase feelings of anxiety or cause headaches during the first few weeks of taking it. These effects should go away over time.
  • More likely than other antidepressants to interact with other medications you're taking.
  • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
  • You shouldn’t take Viibryd (Vilazodone) if you have severe liver problems.
  • Can’t take Viibryd (Vilazodone) with drugs called monoamine oxidase inhibitors (MAOIs).
  • Need to avoid drinking alcohol while taking Viibryd (Vilazodone).
Used for
Dosage forms
  • Pill
  • Delayed release capsule
  • Liquid
  • Pill
Price
Lowest price near you
$4
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Lowest price near you
$240.4
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Reviews
1319 
62%
think this treatment is worth it
40%
think this treatment works well
16%
think this treatment is a hassle

Have you used Prozac (Fluoxetine)?

Leave a review
95 
67%
think this treatment is worth it
63%
think this treatment works well
13%
think this treatment is a hassle

Have you used Viibryd (Vilazodone)?

Leave a review
Side effects
1possible side effects
  • Decreased libido
    4%
See more detailed side effects
10possible side effects
  • Diarrhea
    28%
  • Nausea
    23%
  • Dizziness
    9%
  • Dry mouth
    8%
  • Insomnia
    6%
  • Vomiting
    5%
  • Decreased libido
    5%
  • Abnormal dreams
    4%
  • Libido decreased
    4%
  • Fatigue
    4%
See more detailed side effects
Risks and warnings
  • Suicidal thoughts or behavior

    Age 24 years or younger

  • Serotonin syndrome

    Using other medications that affect serotonin

  • Withdrawal

    Stopping Prozac (Fluoxetine) suddenly

  • Heart problems

    History of heart problems

    ...and 2 more risk factors

  • Increased bleeding

    Taking other blood-thinning drugs

  • Mania

    History of bipolar disorder

    ...and 1 more risk factors

See more detailed risks and warnings
  • Suicidal thoughts or behavior

    Age 18 years or younger

  • Monoamine oxidase inhibitor (MAOI) interaction

    Taking Viibryd (Vilazodone) with MAOIs

    ...and 1 more risk factors

  • Serotonin syndrome

    Taking Viibryd (Vilazodone) with other drugs that increase serotonin

  • Abnormal bleeding

    Taking Viibryd (Vilazodone) with NSAIDs, warfarin, aspirin, or other drugs that affect clotting

  • Risk to fetus

    Women of childbearing age

  • Eye problems

    History of glaucoma

  • Activation of mania/hypomania

    History of bipolar disorder (mixed/mania)

See more detailed risks and warnings