Compare Prozac vs. Wellbutrin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Prozac (fluoxetine)

Prescription only

Wellbutrin (Bupropion)

Prescription only
Improves mood and helps you relax.

Prozac (fluoxetine) is good for treating depression and anxiety. It's more energizing than other antidepressants, so it may not be the best choice for people who have trouble sleeping.

3.5/ 5 average rating with 1319 reviewsforProzac
Improves mood.

Wellbutrin (Bupropion) is good for treating depression and has fewer sexual side effects than other antidepressants, but you need to be okay with avoiding alcohol.

3.4/ 5 average rating with 1164 reviewsforWellbutrin
Upsides
  • Effectively treats a variety of mental health conditions such as depression, OCD, and panic disorder.
  • It's more energizing than other antidepressants, so it's good for people who have low energy.
  • Might be a good option for treating children with depression and/or OCD.
  • Doesn't have effects on the heart unlike other antidepressants so it may be a better treatment choice for older people.
  • Can cause a significant amount of weight loss which is an added benefit for those who are overweight or obese.
  • Effective at relieving depression symptoms.
  • Causes fewer sexual side effects than other antidepressants. Can actually boost sex drive for some people.
  • Can be taken with other antidepressants to counteract their sexual side effects.
  • Has some stimulant effects, so it can be energizing.
  • Can help with ADHD symptoms.
  • Also used to suppress appetite and help you quit smoking.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
Downsides
  • Takes at least 1 to 2 weeks to kick in and can take up to 12 weeks for maximum effect. Prozac (fluoxetine) tends to take more time to start working compared to similar alternatives.
  • Can lower your sex drive.
  • Can increase the risk of suicidal thoughts and/or behavior in those age 24 or younger.
  • You may need to try out several different antidepressants before you find the one that works for you.
  • Wellbutrin (Bupropion) can be stimulating, so it can cause anxiety or insomnia the first few days you're taking it.
  • Generally not as good as other antidepressants for people who have anxiety.
  • It's less likely to cause weight gain than other antidepressants.
  • Has a higher risk of causing seizures, especially if you have a seizure disorder, eating disorder, or if you drink alcohol. So, it's not a good medication if you drink a lot.
  • It contains the same ingredient as a medication that helps you to stop smoking, (Zyban), so these two meds can't be used together.
  • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
Used for
Dosage forms
  • Pill
  • Delayed-release pill
  • Liquid
  • Pill
  • Extended release
Price
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Reviews
1319 reviews so far
62%
saidit'sworth it
40%
saiditworked well
16%
saidit'sa big hassle

Have you used Prozac (fluoxetine)?

Leave a review
1164 reviews so far
60%
saidit'sworth it
40%
saiditworked well
13%
saidit'sa big hassle

Have you used Wellbutrin (Bupropion)?

Leave a review
Side effects
22possible side effects
  • Inability to sleep
    33%
  • Nausea
    28%
  • Lack of energy
    21%
  • Anxiety
    15%
  • Sleepiness
    13%
  • Tremor
    13%
  • Nervousness
    11%
  • Yawn
    11%
  • Indigestion
    10%
  • Sore throat
    10%
  • Dry mouth
    9%
  • Flu syndrome
    8%
  • Diarrhea
    8%
  • Loss of appetite
    8%
  • Sweating
    8%
  • Impotence
    7%
  • Abnormal ejaculation
    7%
  • Sinus infection
    6%
  • Lower sex drive
    5%
  • Abnormal dreams
    5%
  • Rash
    4%
  • Widening of blood vessels
    2%
See more detailed side effects
29possible side effects
  • Agitation
    32%
  • Dry mouth
    28%
  • Constipation
    26%
  • Headache/migraine
    26%
  • Nausea/vomiting
    23%
  • Dizziness
    22%
  • Excessive sweating
    22%
  • Tremor
    21%
  • Sleepiness
    20%
  • Insomnia
    19%
  • Blurred vision
    15%
  • Tachycardia
    11%
  • Confusion
    8%
  • Rash
    8%
  • Hostility
    6%
  • Auditory disturbance
    5%
  • Menstrual complaints
    5%
  • Cardiac arrhythmias
    5%
  • Impaired sleep quality
    4%
  • Sensory disturbance
    4%
  • Appetite increase
    4%
  • Palpitations
    4%
  • Hypertension
    4%
  • Impotence
    3%
  • Anxiety
    3%
  • Decreased libido
    3%
  • Gustatory disturbance
    3%
  • Dyspepsia
    3%
  • Hypotension
    3%
See more detailed side effects
Risks and risk factors
  • Suicidal thoughts or behavior
    • Age 24 or younger
  • Serotonin syndrome
    • Antidepressants
    • Lithium
    • Ultram
    • Imitrex
    • Remeron
    • Lexapro
    • Dilaudid
    • St. John's Wort
  • Skin rash
  • Weight loss
    • People with an eating disorder
  • Increased bleeding risk
    • Taking NSAIDS or blood-thinning drugs
  • Abnormal heart rhythm
    • People with heart rhythm problems or a family history of them
    • Low potassium level
    • Low magnesium level
    • Recent heart attack
    • Using other drugs that affect heart rhythm
    • Overdose
    • People with liver problems
See more detailed risks and warnings
  • Suicidal thoughts or behavior
    • Age 24 years or younger
  • Psychiatric effects for smoking cessation
    • History of depression
    • History of bipolar disorder
    • At risk for bipolar disorder
    • Withdrawing from nicotine
  • Seizures
    • History of seizures
    • Alcoholism
    • Eating disorder
    • Higher dose
    • Drug interactions
  • Mania
    • History of bipolar disorder
    • At risk for bipolar disorder
  • Increased side effects
    • Current kidney problems
    • Current liver problems
  • Weight loss
See more detailed risks and warnings