Compare Prozac vs. Xanax

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Prozac
(fluoxetine)

Xanax
(alprazolam)

Improves mood and helps you relax. Prozac (Fluoxetine) is good for treating depression and anxiety. It's more energizing than other antidepressants, but may not be the best choice for people who have trouble sleeping.Helps you relax. Xanax (Alprazolam) is okay for occasional or short-term use (up to 4 weeks) for anxiety, and longer-term for panic attacks. More likely to cause withdrawal symptoms compared to similar drugs.
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Coupons for Prozac
Best available price for 30 (20mg) capsules of prozac
Coupons for Xanax
Best available price for 60 (0.5mg) tablets of xanax
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.74Prozac
Reviews for Prozac
62%
of people (All ages) say Prozac is worth it
40%
say it works well
16%
say it's a big hassle
1319 reviews
Have you used Prozac (fluoxetine)?
Worth itNot sureNot worth it
Reviews for Xanax
74%
-12% worse vs. Prozac
55%
-15% worse vs. Prozac
13%
-3% worse vs. Prozac
1287 reviews
Have you used Xanax (alprazolam)?
Worth itNot sureNot worth it
Side effects
ProzacXanax
  • Nausea 13%
  • Headache 2%
  • Sleep difficulty 18%
  • Nervousness 5%
  • Drowsiness 7%
  • Anxiety 6%
  • Diarrhea 4%
  • Muscle weakness 5%
  • Loss of appetite 7%
  • Dizziness 3%
More Prozac side effects »
  • Drowsiness 34%
  • Fatigue and tiredness 6%
  • Impaired coordination 23%
  • Irritability 3%
  • Memory impairment 11%
  • Increased appetite 10%
More Xanax side effects »
How it works
ProzacXanax
Prozac (Fluoxetine) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.Xanax (Alprazolam) is a fast-acting benzodiazepine. It affects neurotransmitters in the brain and calms the nervous system. This reduces anxiety and can cause sleepiness.
Type of medication
ProzacXanax
Prescription onlyPrescription only
Available as
ProzacXanax
  • Pill
  • Delayed release capsule
  • Liquid
  • Pill
  • Extended release
  • Dissolving tablet
  • Liquid
Used for
ProzacXanax
Risk factors for serious side effects
ProzacXanax
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • Stopping Prozac (Fluoxetine) suddenly
  • History of heart problems
  • History of liver problems
Detailed Prozac (fluoxetine) risks & warnings »
  • History of drug abuse
  • Taking with alcohol or drugs
  • Taking more than 4 mg/day or longer than 12 weeks
  • Stopping Xanax (Alprazolam) suddenly
  • Severely depressed
Detailed Xanax (alprazolam) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
ProzacXanax
No alcohol related info.
  • Not safe to use with alcohol.
  • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
Food
ProzacXanax
  • Take in the morning with food to avoid side effects.
No food related info.
Kidneys and liver
ProzacXanax
No kidneys and liver related info.
  • Processed by the liver, so might not be the best choice if you have liver problems.
Sex
ProzacXanax
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
No sex related info.
Sleep
ProzacXanax
No sleep related info.
  • Can cause temporary dizziness and drowsiness.
  • Can cause memory problems, drowsiness, dizziness, and confusion.
Upsides and benefits
ProzacXanax
  • Effective at relieving depression and anxiety symptoms.
  • Lowers relapse rates of depression and bulimia nervosa.
  • Causes less sleepiness than other antidepressants.
  • It's more energizing than other antidepressants, so it's good for people who have low energy.
  • It has been used to treat depression for a long time, so there's a lot of information available about how it works and how safe it is.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
  • Effective at relieving short-term anxiety.
  • Effective longer-term for panic attacks.
  • Can be used together with antidepressants to manage anxiety disorders. Especially helpful for anxiety symptoms while you wait for an antidepressant to kick in (it can take several weeks).
Downsides and risks
ProzacXanax
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
  • Can increase feelings of anxiety or cause headaches during the first few weeks of taking it. These effects should go away over time.
  • More likely than other antidepressants to interact with other medications you're taking.
  • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
  • Processed by the liver, so might not be the best choice if you have liver problems.
  • Can cause memory problems, drowsiness, dizziness, and confusion.
  • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
  • Compared to other benzodiazepines, more likely to cause withdrawal if you take it for a long time and then stop suddenly.
Tips from our pharmacists for people taking the medication
ProzacXanax
  • Take in the morning with food to avoid side effects.
  • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
  • Stop taking it slowly to avoid getting withdrawal symptoms.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
  • Good for short-term relief of anxiety symptoms.
  • Starts working in 45 minutes when swallowed.
  • Can cause temporary dizziness and drowsiness.
  • Addictive. Long-term use can cause dependence or abuse.
  • Not safe to use with alcohol.
Learn more
More about ProzacSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Prozac (fluoxetine)?
Worth itNot sureNot worth it
More about XanaxSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Xanax (alprazolam)?
Worth itNot sureNot worth it