Compare Prozac vs. Zoloft

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Prozac
(fluoxetine)

Zoloft
(sertraline)

Improves mood and helps you relax. Prozac (Fluoxetine) is good for treating depression and anxiety. It's more energizing than other antidepressants, but may not be the best choice for people who have trouble sleeping.Improves mood and helps you relax. Zoloft (Sertraline) is good for treating depression and anxiety. It's more likely to cause insomnia and diarrhea than other antidepressants.
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Coupons for Prozac
Best available price for 30 (20mg) capsules of fluoxetine
Coupons for Zoloft
Best available price for 30 (100mg) tablets of sertraline
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.74Prozac
Reviews for Prozac (fluoxetine)
62%
of people (All ages) say Prozac (fluoxetine) is worth it
40%
say it works well
16%
say it's a big hassle
1319 reviews
Have you used Prozac (fluoxetine)?
Worth itNot sureNot worth it
Reviews for Zoloft (sertraline)
59%
-3% worse vs. Prozac (fluoxetine)
41%
+1% better vs. Prozac (fluoxetine)
15%
+1% better vs. Prozac (fluoxetine)
1472 reviews
Have you used Zoloft (sertraline)?
Worth itNot sureNot worth it
Side effects
ProzacZoloft
  • Nausea 13%
  • Headache 2%
  • Sleep difficulty 18%
  • Nervousness 5%
  • Drowsiness 7%
  • Anxiety 6%
  • Diarrhea 4%
  • Muscle weakness 5%
  • Loss of appetite 7%
  • Dizziness 3%
More Prozac side effects »
  • Nausea 14%
  • Diarrhea/loose stools 9%
  • Sleep difficulty 7%
  • Mouth dry 7%
  • Drowsiness 7%
  • Dizziness 5%
  • Tremor 8%
  • Fatigue 3%
  • Sweating increased 5%
  • Constipation 2%
More Zoloft side effects »
How it works
ProzacZoloft
Prozac (Fluoxetine) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.Zoloft (Sertraline) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases the activity of serotonin in the brain, which regulates mood.
Type of medication
ProzacZoloft
Prescription only
Prescription only
Available as
ProzacZoloft
  • Pill
  • Delayed release capsule
  • Liquid
  • Pill
  • Liquid
Used for
ProzacZoloft
Risk factors for serious side effects
ProzacZoloft
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • Stopping Prozac (Fluoxetine) suddenly
  • History of heart problems
  • History of liver problems
Detailed Prozac (fluoxetine) risks & warnings »
  • Under 24 years old
  • Interactions with other medications
  • Stopping Zoloft (Sertraline) suddenly
  • Taking with blood-thinning drugs
  • Elderly
Detailed Zoloft (sertraline) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
ProzacZoloft
No interactions related info.
  • It interacts with St. John's Wort and Tryptophan.
Food
ProzacZoloft
  • Take in the morning with food to avoid side effects.
No food related info.
Sex
ProzacZoloft
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
Sleep
ProzacZoloft
No sleep related info.
  • Causes less drowsiness than other antidepressants.
  • Zoloft (Sertraline) may increase the risk of low sodium levels in the blood (hyponatremia). Watch out for symptoms including headache, difficulty concentrating, memory problems, confusion, weakness, and unsteadiness, which may lead to falls. Talk to a doctor right away before developing more serious symptoms, such as hallucination, fainting, coma, and death.
Upsides and benefits
ProzacZoloft
  • Effective at relieving depression and anxiety symptoms.
  • Lowers relapse rates of depression and bulimia nervosa.
  • Causes less sleepiness than other antidepressants.
  • It's more energizing than other antidepressants, so it's good for people who have low energy.
  • It has been used to treat depression for a long time, so there's a lot of information available about how it works and how safe it is.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
  • Effective at lowering symptoms and relapse rates of depression and anxiety disorders.
  • Causes less drowsiness than other antidepressants.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
Downsides and risks
ProzacZoloft
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
  • Can increase feelings of anxiety or cause headaches during the first few weeks of taking it. These effects should go away over time.
  • More likely than other antidepressants to interact with other medications you're taking.
  • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
  • More likely to cause diarrhea than other antidepressants.
  • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
Tips from our pharmacists for people taking the medication
ProzacZoloft
  • Take in the morning with food to avoid side effects.
  • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
  • Stop taking it slowly to avoid getting withdrawal symptoms.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
  • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
  • It interacts with St. John's Wort and Tryptophan.
  • Stop taking it slowly to avoid getting withdrawal symptoms.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
Learn more
More about ProzacSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Prozac (fluoxetine)?
Worth itNot sureNot worth it
More about ZoloftSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zoloft (sertraline)?
Worth itNot sureNot worth it