Compare Reclast vs. Actonel

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Reclast
(zoledronate)

Actonel
(risedronate)

Prevents bone loss. Reclast (Zoledronate) is a first-choice treatment for osteoporosis and is available as a generic, but you have to see a doctor to get each dose.Prevents bone loss. Actonel (risedronate) is a first-choice treatment for osteoporosis and is available as a generic, but taking it can be a hassle.
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Prices and coupon for 1 (1 tablet of 150mg) dose pack of risedronate
Reviews & ratings
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Filter group. All currently selected
4.08Reclast
Reviews for Reclast (zoledronate)
28%
of people (All ages) say Reclast (zoledronate) is worth it
28%
say it works well
36%
say it's a big hassle
Have you used Reclast (zoledronate)?
Worth itNot sureNot worth it
Reviews for Actonel (risedronate)
36%
+8% better vs. Reclast (zoledronate)
19%
-9% worse vs. Reclast (zoledronate)
25%
+11% better vs. Reclast (zoledronate)
Have you used Actonel (risedronate)?
Worth itNot sureNot worth it
Side effects
ReclastActonel
  • Joint pain 4%
  • Fever 13%
  • High blood pressure 1%
  • Headache 4%
  • Muscle pain 8%
  • Pain in extremity 1%
  • Influenza-like illness 6%
  • Nausea 4%
  • Pain 20%
  • Acute phase reaction 20%
More Reclast side effects »
  • Infection 1%
  • Back pain 2%
  • Joint pain 2%
  • Stomach pain 2%
  • Traumatic bone fracture 3%
  • High blood pressure 1%
More Actonel side effects »
How it works
ReclastActonel
Reclast (Zoledronate) is a bisphosphonate. It slows down osteoclasts, the cells that break down bone. This results in greater bone mass and lowers the possibility of fractures.Actonel (risedronate) is a bisphosphonate. It slows down osteoclasts, which are the cells that break down bone. This results in greater bone mass, and lowers the possibility of fractures.
Type of medication
ReclastActonel
Prescription only
Prescription only
Available as
ReclastActonel
  • Injection
  • Pill
Used for
ReclastActonel
Risk factors for serious side effects
ReclastActonel
    • Oral or dental surgery
    • Cancer
    • Poor oral hygiene
        Detailed Reclast (zoledronate) risks & warnings »
        • History of ulcers, or other stomach or esophageal problems
        • History of difficulty swallowing
        • Unable to sit upright or stand for 30 minutes after taking the medicine
          • Oral or dental surgery
          • Cancer
          • Poor oral hygiene
            • History of low calcium in the blood
            Detailed Actonel (risedronate) risks & warnings »
            Pregnancy

            Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

            Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

            Food
            ReclastActonel
            • People on Reclast (Zoledronate) have reported breakdown of the jaw bone. This is rare. This can happen if you have oral or dental surgery, or if you have poor oral hygiene. If you notice pain, swelling or an infection in your jaw, talk to your doctor right away. Also, tell your surgeon that you are taking Reclast (Zoledronate).
            • Although rare, breakdown of the jawbone has happened in people taking Actonel (risedronate). This is more likely to happen if you have oral or dental surgery, or if you have poor oral hygiene. If you notice pain or swelling in your jaw, talk to your doctor right away. Also, tell your surgeon that you are taking Actonel (risedronate) prior to any oral/dental procedures.
            Pain
            ReclastActonel
            No pain related info.
            • Talk to your doctor if you have pain with swallowing, pain in your chest or stomach, or new or worsening heartburn.
            Upsides and benefits
            ReclastActonel
            • Available in generic.
            • You only have to take this once a year.
            • Actonel (risedronate) is one of the first choice medicines to treat osteoporosis.
            • It is available in generic.
            • It is available in tablets that can be taken by mouth once or twice a month, once a week, or once a day.
            Downsides and risks
            ReclastActonel
            • You have to go to your doctor's office or an infusion center to get each dose by IV infusion.
            • You have to take Actonel (risedronate) first thing in the morning with a full glass of water.
            • You have to remain upright for at least 30 minutes after you take it, which can be a problem if you have trouble moving.
            Tips from our pharmacists for people taking the medication
            ReclastActonel
            • Given as an intravenous infusion.
            • Eat normally and drink at least two glasses of liquid before your infusion.
            • Talk to your doctor if you develop swelling, pain, or a sore in your jaw.
            • Call your doctor if you develop pain in your hips, thighs or legs.
            • You can take acetaminophen (Tylenol) to lower fever and chills from the infusion.
            • If you have to have dental or oral surgery, tell your surgeon that you're taking this medication.
            • Drink plenty of liquids while you're on this medication.
            • If you're taking the immediate release medicine, take it first thing when you wake up by swallowing the whole pill with a full glass of water.
            • Remain sitting or standing, and don't take any other medications, vitamins, or supplements for at least 30 minutes after you take Actonel (risedronate).
            • If you forget to take your dose, skip it and take it the following morning.
            • Keep taking your calcium and vitamin D.
            • Talk to your doctor if you have pain with swallowing, pain in your chest or stomach, or new or worsening heartburn.
            • If you develop pain in your jaw, hips, or thighs, call your doctor.
            Learn more
            More about ReclastSide effectsReviews & ratingsAlternativesFDA package insert
            Have you used Reclast (zoledronate)?
            Worth itNot sureNot worth it
            More about ActonelSide effectsReviews & ratingsAlternativesFDA package insert
            Have you used Actonel (risedronate)?
            Worth itNot sureNot worth it