Compare Reclast vs. Actonel

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Reclast
(zoledronate)

Actonel
(risedronate)

Prevents bone loss. Reclast (zoledronate) is a good choice for osteoporosis if you aren't able to take bisphosphonates by mouth. It is available as a generic, but you have to see a doctor to get each dose.Prevents bone loss. Actonel (risedronate) is a first-choice treatment for osteoporosis and is available as a generic, but taking it can be a hassle.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.08Reclast
Reviews for Reclast
28%
of people (All ages) say Reclast is worth it
28%
say it works well
36%
say it's a big hassle
Have you used Reclast (zoledronate)?
Worth itNot sureNot worth it
Reviews for Actonel
36%
-8% worse vs. Reclast
19%
+9% better vs. Reclast
25%
-11% worse vs. Reclast
Have you used Actonel (risedronate)?
Worth itNot sureNot worth it
Side effects
ReclastActonel
  • Joint pain 4%
  • Fever 13%
  • High blood pressure 1%
  • Muscle aches 8%
  • Headache 4%
  • Pain in arms or legs 1%
  • Nausea 4%
  • Influenza-like illness 6%
  • Pain 20%
More Reclast side effects »
  • Infection 1%
  • Back pain 2%
  • Joint pain 2%
  • Stomach pain 2%
  • Traumatic bone fracture 3%
  • High blood pressure 1%
More Actonel side effects »
How it works
ReclastActonel
Reclast (zoledronate) is a bisphosphonate. It slows down the cells that break down bone. This results in greater bone mass, and lowers the possibility of fractures.Actonel (risedronate) is a bisphosphonate. It slows down osteoclasts, which are the cells that break down bone. This results in greater bone mass, and lowers the possibility of fractures.
Type of medication
ReclastActonel
Prescription onlyPrescription only
Available as
ReclastActonel
  • Injection
  • Pill
Used for
ReclastActonel
Risk factors for serious side effects
ReclastActonel
  • Oral or dental surgery
  • Cancer
  • Poor oral hygiene
  • Low parathyroid hormone
  • History of thyroid surgery
Detailed Reclast (zoledronate) risks & warnings »
  • History of ulcers, or other stomach or esophageal problems
  • History of difficulty swallowing
  • Unable to sit upright or stand for 30 minutes after taking the medicine
  • Oral or dental surgery
  • Cancer
Detailed Actonel (risedronate) risks & warnings »
Pregnancy

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
ReclastActonel
  • People on Reclast (zoledronate) have had breakdown of the jawbone. However, it is rare. It is more likely to happen if you have oral or dental surgery, or if you have poor oral hygiene. If you notice pain or swelling in your jaw, talk to your doctor right away. Also, before any oral/dental procedure, tell your surgeon that you are taking Reclast (zoledronate).
  • Although rare, breakdown of the jawbone has happened in people taking Actonel (risedronate). This is more likely to happen if you have oral or dental surgery, or if you have poor oral hygiene. If you notice pain or swelling in your jaw, talk to your doctor right away. Also, tell your surgeon that you are taking Actonel (risedronate) prior to any oral/dental procedures.
Kidneys and liver
ReclastActonel
  • Reclast (zoledronate) can cause kidney injury, especially in people who already have problems with their kidneys. It is important that you get blood tests done before each dose to measure your kidney function. Reclast (zoledronate) shouldn’t be used in people who have very poor kidney function.
  • It can't be used if you have really poor kidney function.
No kidneys and liver related info.
Pain
ReclastActonel
  • Joint pain and muscle pain are common side effects after the infusion.
  • Talk to your doctor if you have pain with swallowing, pain in your chest or stomach, or new or worsening heartburn.
Upsides and benefits
ReclastActonel
  • Available in generic.
  • Depending on what you're using it for, you may only need to take it as a one-time dose, or every 1 to 2 years.
  • Actonel (risedronate) is one of the first choice medicines to treat osteoporosis.
  • It is available in generic.
  • It is available in tablets that can be taken by mouth once or twice a month, once a week, or once a day.
Downsides and risks
ReclastActonel
  • You have to go to your doctor's office or an infusion center to get each dose by IV infusion.
  • It can't be used if you have really poor kidney function.
  • Joint pain and muscle pain are common side effects after the infusion.
  • You have to take Actonel (risedronate) first thing in the morning with a full glass of water.
  • You have to remain upright for at least 30 minutes after you take it, which can be a problem if you have trouble moving.
Tips from our pharmacists for people taking the medication
ReclastActonel
  • Eat normally and drink at least 2 glasses of liquid before your infusion.
  • You can take acetaminophen (Tylenol) to lower fever and chills from the infusion.
  • Talk to your doctor if you develop swelling, pain, or soreness in your jaw.
  • Call your doctor if you develop pain in your hips, thighs, or legs.
  • If you have to have dental or oral surgery, tell your surgeon that you're taking this medication.
  • Drink plenty of liquids while you're on this medicine.
  • If you're taking the immediate release medicine, take it first thing when you wake up by swallowing the whole pill with a full glass of water.
  • Remain sitting or standing, and don't take any other medications, vitamins, or supplements for at least 30 minutes after you take Actonel (risedronate).
  • If you forget to take your dose, skip it and take it the following morning.
  • Keep taking your calcium and vitamin D.
  • Talk to your doctor if you have pain with swallowing, pain in your chest or stomach, or new or worsening heartburn.
  • If you develop pain in your jaw, hips, or thighs, call your doctor.
Learn more
More about ReclastSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Reclast (zoledronate)?
Worth itNot sureNot worth it
More about ActonelSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Actonel (risedronate)?
Worth itNot sureNot worth it