Compare Reclast vs. Actonel

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Reclast
(Zoledronate)

Actonel
(Risedronate)

Prevents bone loss. Reclast (Zoledronate) is a first-choice treatment for osteoporosis and is available as a generic, but you have to see a doctor to get each dose.Prevents bone loss. Actonel (Risedronate) is a first-choice treatment for osteoporosis and is available as a generic, but how you have to take it can be a hassle.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
3.9166666666666665Reclast
Reviews for Reclast (Zoledronate)
25%
of people say Reclast (Zoledronate) is worth it
25%
say it works well
36%
say it's a big hassle
Reviews for Actonel (Risedronate)
36%
+11% vs. Reclast (Zoledronate)
19%
6% vs. Reclast (Zoledronate)
25%
+11% vs. Reclast (Zoledronate)
Side effects
ReclastActonel
  • Pain 20%
  • Fever 17%
  • Rash 16%
  • Chills 15%
  • Muscle pain 13%
  • Pain in jaw 12%
  • Fatigue 12%
  • Nausea 10%
  • Headache 9%
  • Joint pain 8%
More Reclast side effects »

We haven’t found good data for Actonel side effects.

FDA side effect reports for Actonel »
How it works
ReclastActonel
Reclast (Zoledronate) is a bisphosphonate. It slows down osteoclasts, the cells that break down bone. This results in greater bone mass and lowers the possibility of fractures.Actonel (Risedronate) is a bisphosphonate. It slows down osteoclasts, the cells that break down bone. This results in greater bone mass and lowers the possibility of fractures.
Type of medication
ReclastActonel
BisphosphonatePrescription only
BisphosphonatePrescription only
Available as
ReclastActonel
  • Injection
  • Pill
  • Extended release
Used for (click to learn more)
ReclastActonel
Risk factors for serious side effects
ReclastActonel
    • Oral or dental surgery
    • Cancer
    • Poor oral hygiene
        Detailed Reclast (Zoledronate) risks & warnings »
            • Oral or dental surgery
            • Cancer
            • Poor oral hygiene
                Detailed Actonel (Risedronate) risks & warnings »
                Pregnancy category
                ReclastActonel
                DFDA pregnancy category (Weigh risks vs. benefits)

                Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                See the FDA package insert
                CFDA pregnancy category (Weigh risks vs. benefits)

                Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                See the FDA package insert
                Alcohol
                No specific alcohol-related info.No specific alcohol-related info.
                Food
                No specific food-related info.
                • If you're taking the extended release medication, take it after your first meal of the day with at least a half cup of water.
                Kidneys and liver
                No specific kidneys and liver-related info.No specific kidneys and liver-related info.
                Sex
                No specific sex-related info.No specific sex-related info.
                Sleep
                No specific sleep-related info.No specific sleep-related info.
                Weight
                No specific weight-related info.
                • Consider adding weight-bearing exercises as part of your exercise routine.
                Upsides and benefits
                ReclastActonel
                • You only have to take this once a year.
                • Available in generic.
                • Available in oral tablets that can be taken once or twice a month, once a week, or once a day.
                • Available in generic.
                Downsides and risks
                ReclastActonel
                • You have to go to your doctor's office or an infusion center to get each dose by IV infusion.
                • You have to take it first thing in the morning with a full glass of water.
                • You have to remain upright for at least 30 minutes after you take the medication, which can be a problem if you have mobility issues.
                Tips from our pharmacists for people taking the medication
                ReclastActonel
                • Given as an intravenous infusion.
                • Eat normally and drink at least two glasses of liquid before your infusion.
                • Talk to your doctor if you develop swelling, pain, or a sore in your jaw.
                • Call your doctor if you develop pain in your hips, thighs or legs.
                • You can take acetaminophen (Tylenol) to lower fever and chills from the infusion.
                • If you have to have dental or oral surgery, tell your surgeon that you're taking this medication.
                • Drink plenty of liquids while you're on this medication.
                • If you're taking the fast release medication, take it first thing when you wake up by swallowing the whole pill with a full glass of water.
                • Don't eat or drink anything for 30 minutes after you've taken the fast release medication.
                • If you're taking the extended release medication, take it after your first meal of the day with at least a half cup of water.
                • Stay sitting or standing and Don't take any other medications, vitamins or supplements for at least 30 minutes after you take the medication.
                • If you have pain with swallowing, around your chest or stomach, or new or worsening heartburn, talk to your doctor.
                • Call your doctor if you develop pain in your jaw, hips or thighs.
                • Keep taking your calcium and vitamin D.
                • If you forget to take your dose, skip it and take it the following morning.
                • Some of these medications are only taken once or twice a month, others are taken once a week and others once a day. Talk to your pharmacist if you're not sure.
                • Consider adding weight-bearing exercises as part of your exercise routine.
                Learn more
                More about ReclastSide effectsReviews & ratingsAlternativesFDA package insert
                More about ActonelSide effectsReviews & ratingsAlternativesFDA package insert