Compare Reclast vs. Evista

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Reclast
(zoledronate)

Evista
(raloxifene)

Prevents bone loss. Reclast (Zoledronate) is a first-choice treatment for osteoporosis and is available as a generic, but you have to see a doctor to get each dose.Prevents bone loss and lowers your risk of breast cancer. Evista (Raloxifene) is effective at reducing bone loss and lowering the risk of breast cancer in postmenopausal women, but does carry the risk of blood clots.
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Prices and coupon for 30 (60mg) tablets of raloxifene
Reviews & ratings
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4.08Reclast
Reviews for Reclast (zoledronate)
28%
of people (All ages) say Reclast (zoledronate) is worth it
28%
say it works well
36%
say it's a big hassle
Have you used Reclast (zoledronate)?
Worth itNot sureNot worth it

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Have you used Evista (raloxifene)?
Worth itNot sureNot worth it
Side effects
ReclastEvista
  • Joint pain 4%
  • Fever 13%
  • High blood pressure 1%
  • Headache 4%
  • Muscle pain 8%
  • Pain in extremity 1%
  • Influenza-like illness 6%
  • Nausea 4%
  • Pain 20%
  • Acute phase reaction 20%
More Reclast side effects »
  • Joint pain 2%
  • Flu syndrome 3%
  • Any side effect 2%
  • Hot flashes 4%
  • Bronchitis 1%
More Evista side effects »
How it works
ReclastEvista
Reclast (Zoledronate) is a bisphosphonate. It slows down osteoclasts, the cells that break down bone. This results in greater bone mass and lowers the possibility of fractures.Evista (Raloxifene) is a selective estrogen receptor modulator (SERM). It acts like estrogen to make your bones stronger and less likely to break, and also protects breast and uterus tissues from other estrogen effects.
Type of medication
ReclastEvista
Prescription only
Prescription only
Available as
ReclastEvista
  • Injection
  • Pill
Used for
ReclastEvista
Risk factors for serious side effects
ReclastEvista
    • Oral or dental surgery
    • Cancer
    • Poor oral hygiene
        Detailed Reclast (zoledronate) risks & warnings »
        • History of stroke
        • Heart and blood vessel problems
        • History of mini stroke (TIA)
        • Atrial fibrillation
        • Smoking
        • High blood pressure
          • History of high triglycerides
            Detailed Evista (raloxifene) risks & warnings »
            Pregnancy

            Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

            Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

            Alcohol
            ReclastEvista
            No alcohol related info.
            • Regular exercise, cutting back on smoking, and drinking less alcohol can also reduce your risk of bone loss.
            Food
            ReclastEvista
            • People on Reclast (Zoledronate) have reported breakdown of the jaw bone. This is rare. This can happen if you have oral or dental surgery, or if you have poor oral hygiene. If you notice pain, swelling or an infection in your jaw, talk to your doctor right away. Also, tell your surgeon that you are taking Reclast (Zoledronate).
            • Take 1 tablet daily with or without food about the same time each day. It’s important to read the information you get with your medicine about how to take Evista (Raloxifene).
            Kidneys and liver
            ReclastEvista
            No kidneys and liver related info.
            • Evista (Raloxifene) is processed by the kidney and liver. If you have kidney or liver problems, talk to your doctor because you may need a different dose.
            Upsides and benefits
            ReclastEvista
            • Available in generic.
            • You only have to take this once a year.
            • Evista (Raloxifene) doesn’t affect the breast or uterus the same way that estrogen does, so the risk of cancer is much lower.
            • Taking Evista (Raloxifene) with calcium and vitamin D improves spine and hip bone health and lowers the risk of fractures.
            • Lowers total cholesterol and low-density lipoprotein (LDL) cholesterol (the bad cholesterol).
            Downsides and risks
            ReclastEvista
            • You have to go to your doctor's office or an infusion center to get each dose by IV infusion.
            • Can only take Evista (Raloxifene) once you’re in menopause. You can't take it if you're pregnant or breastfeeding.
            • Evista (Raloxifene) isn’t as effective as tamoxifen at lowering the risk of invasive breast cancer.
            • Shouldn’t take it with any other forms of estrogen (pills, patches, or injection).
            • It doesn’t increase bone strength as much as estrogen does and isn’t effective for treating hot flashes.
            Tips from our pharmacists for people taking the medication
            ReclastEvista
            • Given as an intravenous infusion.
            • Eat normally and drink at least two glasses of liquid before your infusion.
            • Talk to your doctor if you develop swelling, pain, or a sore in your jaw.
            • Call your doctor if you develop pain in your hips, thighs or legs.
            • You can take acetaminophen (Tylenol) to lower fever and chills from the infusion.
            • If you have to have dental or oral surgery, tell your surgeon that you're taking this medication.
            • Drink plenty of liquids while you're on this medication.
            • Take 1 tablet daily with or without food about the same time each day. It’s important to read the information you get with your medicine about how to take Evista (Raloxifene).
            • Your doctor may tell you to take calcium and vitamin D with Evista (Raloxifene) to prevent osteoporosis (bone thinning and loss), especially if you don’t get enough in your diet.
            • Regular exercise, cutting back on smoking, and drinking less alcohol can also reduce your risk of bone loss.
            Learn more
            More about ReclastSide effectsReviews & ratingsAlternativesFDA package insert
            Have you used Reclast (zoledronate)?
            Worth itNot sureNot worth it
            More about EvistaSide effectsReviews & ratingsAlternativesFDA package insert
            Have you used Evista (raloxifene)?
            Worth itNot sureNot worth it