Compare Reclast vs. Evista

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Reclast
(zoledronate)

Evista
(raloxifene)

Prevents bone loss. Reclast (zoledronate) is a good choice for osteoporosis if you aren't able to take bisphosphonates by mouth. It is available as a generic, but you have to see a doctor to get each dose.Prevents bone loss and lowers your risk of breast cancer. Evista (Raloxifene) is effective at reducing bone loss and lowering the risk of breast cancer in postmenopausal women, but does carry the risk of blood clots.
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Coupons for Reclast
Best available price for 100 (100ml of 5mg/100ml solution) bottles of reclast
Coupons for Evista
Best available price for 30 (60mg) tablets of evista
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.08Reclast
Reviews for Reclast
28%
of people (All ages) say Reclast is worth it
28%
say it works well
36%
say it's a big hassle
Have you used Reclast (zoledronate)?
Worth itNot sureNot worth it

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Have you used Evista (raloxifene)?
Worth itNot sureNot worth it
Side effects
ReclastEvista
  • Joint pain 4%
  • Fever 13%
  • High blood pressure 1%
  • Muscle aches 8%
  • Headache 4%
  • Pain in arms or legs 1%
  • Nausea 4%
  • Influenza-like illness 6%
  • Pain 20%
More Reclast side effects »
  • Joint pain 2%
  • Flu syndrome 3%
  • Any side effect 2%
  • Hot flashes 4%
  • Bronchitis 1%
More Evista side effects »
How it works
ReclastEvista
Reclast (zoledronate) is a bisphosphonate. It slows down the cells that break down bone. This results in greater bone mass, and lowers the possibility of fractures.Evista (Raloxifene) is a selective estrogen receptor modulator (SERM). It acts like estrogen to make your bones stronger and less likely to break, and also protects breast and uterus tissues from other estrogen effects.
Type of medication
ReclastEvista
Prescription onlyPrescription only
Available as
ReclastEvista
  • Injection
  • Pill
Used for
ReclastEvista
Risk factors for serious side effects
ReclastEvista
  • Oral or dental surgery
  • Cancer
  • Poor oral hygiene
  • Low parathyroid hormone
  • History of thyroid surgery
Detailed Reclast (zoledronate) risks & warnings »
  • History of stroke
  • Heart and blood vessel problems
  • History of mini stroke (TIA)
  • Atrial fibrillation
  • Smoking
Detailed Evista (raloxifene) risks & warnings »
Pregnancy

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Alcohol
ReclastEvista
No alcohol related info.
  • Regular exercise, cutting back on smoking, and drinking less alcohol can also reduce your risk of bone loss.
Food
ReclastEvista
  • People on Reclast (zoledronate) have had breakdown of the jawbone. However, it is rare. It is more likely to happen if you have oral or dental surgery, or if you have poor oral hygiene. If you notice pain or swelling in your jaw, talk to your doctor right away. Also, before any oral/dental procedure, tell your surgeon that you are taking Reclast (zoledronate).
  • Take 1 tablet daily with or without food about the same time each day. It’s important to read the information you get with your medicine about how to take Evista (Raloxifene).
Kidneys and liver
ReclastEvista
  • Reclast (zoledronate) can cause kidney injury, especially in people who already have problems with their kidneys. It is important that you get blood tests done before each dose to measure your kidney function. Reclast (zoledronate) shouldn’t be used in people who have very poor kidney function.
  • It can't be used if you have really poor kidney function.
  • Evista (Raloxifene) is processed by the kidney and liver. If you have kidney or liver problems, talk to your doctor because you may need a different dose.
Pain
ReclastEvista
  • Joint pain and muscle pain are common side effects after the infusion.
No pain related info.
Upsides and benefits
ReclastEvista
  • Available in generic.
  • Depending on what you're using it for, you may only need to take it as a one-time dose, or every 1 to 2 years.
  • Evista (Raloxifene) doesn’t affect the breast or uterus the same way that estrogen does, so the risk of cancer is much lower.
  • Taking Evista (Raloxifene) with calcium and vitamin D improves spine and hip bone health and lowers the risk of fractures.
  • Lowers total cholesterol and low-density lipoprotein (LDL) cholesterol (the bad cholesterol).
Downsides and risks
ReclastEvista
  • You have to go to your doctor's office or an infusion center to get each dose by IV infusion.
  • It can't be used if you have really poor kidney function.
  • Joint pain and muscle pain are common side effects after the infusion.
  • Can only take Evista (Raloxifene) once you’re in menopause. You can't take it if you're pregnant or breastfeeding.
  • Evista (Raloxifene) isn’t as effective as tamoxifen at lowering the risk of invasive breast cancer.
  • Shouldn’t take it with any other forms of estrogen (pills, patches, or injection).
  • It doesn’t increase bone strength as much as estrogen does and isn’t effective for treating hot flashes.
Tips from our pharmacists for people taking the medication
ReclastEvista
  • Eat normally and drink at least 2 glasses of liquid before your infusion.
  • You can take acetaminophen (Tylenol) to lower fever and chills from the infusion.
  • Talk to your doctor if you develop swelling, pain, or soreness in your jaw.
  • Call your doctor if you develop pain in your hips, thighs, or legs.
  • If you have to have dental or oral surgery, tell your surgeon that you're taking this medication.
  • Drink plenty of liquids while you're on this medicine.
  • Take 1 tablet daily with or without food about the same time each day. It’s important to read the information you get with your medicine about how to take Evista (Raloxifene).
  • Your doctor may tell you to take calcium and vitamin D with Evista (Raloxifene) to prevent osteoporosis (bone thinning and loss), especially if you don’t get enough in your diet.
  • Regular exercise, cutting back on smoking, and drinking less alcohol can also reduce your risk of bone loss.
Learn more
More about ReclastSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Reclast (zoledronate)?
Worth itNot sureNot worth it
More about EvistaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Evista (raloxifene)?
Worth itNot sureNot worth it