Compare Reclast vs. Evista

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Reclast (zoledronate)

Prescription only

Evista (Raloxifene)

Prescription only
Prevents bone loss.

Reclast (zoledronate) is a good choice for osteoporosis if you aren't able to take bisphosphonates by mouth. It is available as a generic, but you have to see a doctor to get each dose.

4.1/ 7 average rating with 39 reviewsforReclast
Prevents bone loss and lowers your risk of breast cancer.

Evista (Raloxifene) is effective at reducing bone loss and lowering the risk of breast cancer in postmenopausal women, but does carry the risk of blood clots.

  • Available in generic.
  • Depending on what you're using it for, you may only need to take it as a one-time dose, or every 1 to 2 years.
  • Evista (Raloxifene) doesn’t affect the breast or uterus the same way that estrogen does, so the risk of cancer is much lower.
  • Taking Evista (Raloxifene) with calcium and vitamin D improves spine and hip bone health and lowers the risk of fractures.
  • Lowers total cholesterol and low-density lipoprotein (LDL) cholesterol (the bad cholesterol).
  • You have to go to your doctor's office or an infusion center to get each dose by IV infusion.
  • It can't be used if you have really poor kidney function.
  • Joint pain and muscle pain are common side effects after the infusion.
  • Can only take Evista (Raloxifene) once you’re in menopause. You can't take it if you're pregnant or breastfeeding.
  • Evista (Raloxifene) isn’t as effective as tamoxifen at lowering the risk of invasive breast cancer.
  • Shouldn’t take it with any other forms of estrogen (pills, patches, or injection).
  • It doesn’t increase bone strength as much as estrogen does and isn’t effective for treating hot flashes.
Used for
Dosage forms
  • Injection
  • Pill
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Side effects
10possible side effects
  • Muscle aches
  • Fatigue
  • Headache
  • Muscle pain
  • Pain
  • Chills
  • Influenza-like illness
  • Stomach pain
  • Shortness of breath
  • Feeling unwell
See more detailed side effects
6possible side effects
  • Any side effect
  • Peripheral edema
  • Muscle spasms/leg cramps
  • Hot Flashes
  • Cholelithiasis
  • Venous thromboembolic events
See more detailed side effects
Risks and warnings
  • Problems in the jawbone

    Oral or dental surgery

    ...and 2 more risk factors

  • Low calcium in the blood

    Low parathyroid hormone

    ...and 2 more risk factors

  • Kidney injury

    Kidney disease

    ...and 3 more risk factors

See more detailed risks and warnings
  • Increased risk of stroke

    History of stroke

    ...and 5 more risk factors

  • Elevated triglycerides (fats in blood)

    History of high triglycerides

See more detailed risks and warnings