Compare Reclast vs. Prolia

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Reclast
(zoledronate)

Prolia
(denosumab)

Prevents bone loss. Reclast (zoledronate) is a good choice for osteoporosis if you aren't able to take bisphosphonates by mouth. It is available as a generic, but you have to see a doctor to get each dose.Prevents bone loss. Prolia (Denosumab) is an effective and convenient treatment for osteoporosis if other options haven’t worked or aren’t appropriate for you. There’re risks of some rare side effects, so make sure you're following up with your doctor regularly.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Coupons for Reclast
Best available price for 100 (100ml of 5mg/100ml solution) bottles of reclast
Coupons for Prolia
Best available price for 1 (1ml of 60mg/ml) syringe of prolia
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.08Reclast
Reviews for Reclast
28%
of people (All ages) say Reclast is worth it
28%
say it works well
36%
say it's a big hassle
Have you used Reclast (zoledronate)?
Worth itNot sureNot worth it
Reviews for Prolia
33%
-5% worse vs. Reclast
40%
-12% worse vs. Reclast
27%
-9% worse vs. Reclast
Have you used Prolia (denosumab)?
Worth itNot sureNot worth it
Side effects
ReclastProlia
  • Joint pain 4%
  • Fever 13%
  • High blood pressure 1%
  • Muscle aches 8%
  • Headache 4%
  • Pain in arms or legs 1%
  • Nausea 4%
  • Influenza-like illness 6%
  • Pain 20%
More Reclast side effects »
  • Pain in extremity 1%
  • Hypercholesterolemia 1%
  • Ankle and leg swelling 1%
  • Ear, nose, or throat infection 1%
  • Sciatica 1%
More Prolia side effects »
How it works
ReclastProlia
Reclast (zoledronate) is a bisphosphonate. It slows down the cells that break down bone. This results in greater bone mass, and lowers the possibility of fractures.Prolia (Denosumab) is a monoclonal antibody. It blocks a protein that sends signals to break down your bones, and therefore prevents bone loss.
Type of medication
ReclastProlia
Prescription onlyPrescription only
Available as
ReclastProlia
  • Injection
  • Injection
Used for
ReclastProlia
Risk factors for serious side effects
ReclastProlia
  • Oral or dental surgery
  • Cancer
  • Poor oral hygiene
  • Low parathyroid hormone
  • History of thyroid surgery
Detailed Reclast (zoledronate) risks & warnings »
  • Taking steroids
  • Kidney problems
  • Not taking calcium supplements
  • Taking other medicines that can lower calcium blood levels
  • History of hypoparathyroidism (low levels of parathyroid hormone)
Detailed Prolia (denosumab) risks & warnings »
Pregnancy

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Food
ReclastProlia
  • People on Reclast (zoledronate) have had breakdown of the jawbone. However, it is rare. It is more likely to happen if you have oral or dental surgery, or if you have poor oral hygiene. If you notice pain or swelling in your jaw, talk to your doctor right away. Also, before any oral/dental procedure, tell your surgeon that you are taking Reclast (zoledronate).
No food related info.
Kidneys and liver
ReclastProlia
  • Reclast (zoledronate) can cause kidney injury, especially in people who already have problems with their kidneys. It is important that you get blood tests done before each dose to measure your kidney function. Reclast (zoledronate) shouldn’t be used in people who have very poor kidney function.
  • It can't be used if you have really poor kidney function.
No kidneys and liver related info.
Pain
ReclastProlia
  • Joint pain and muscle pain are common side effects after the infusion.
  • Can cause skin irritation, joint pain, limb pain, and back pain.
Upsides and benefits
ReclastProlia
  • Available in generic.
  • Depending on what you're using it for, you may only need to take it as a one-time dose, or every 1 to 2 years.
  • Prolia (Denosumab) is effective at preventing bone loss, making your bones stronger and lowering your chance of getting a fracture.
  • Only need to get an injection every 6 months, so you don’t have to remember to take something every day.
Downsides and risks
ReclastProlia
  • You have to go to your doctor's office or an infusion center to get each dose by IV infusion.
  • It can't be used if you have really poor kidney function.
  • Joint pain and muscle pain are common side effects after the infusion.
  • Approved for women only after they’ve reached menopause. Don’t use this if you’re pregnant or planning to become pregnant.
  • Can lower blood calcium levels. You might need to take calcium supplements to prevent this.
  • Not available as a generic.
Tips from our pharmacists for people taking the medication
ReclastProlia
  • Eat normally and drink at least 2 glasses of liquid before your infusion.
  • You can take acetaminophen (Tylenol) to lower fever and chills from the infusion.
  • Talk to your doctor if you develop swelling, pain, or soreness in your jaw.
  • Call your doctor if you develop pain in your hips, thighs, or legs.
  • If you have to have dental or oral surgery, tell your surgeon that you're taking this medication.
  • Drink plenty of liquids while you're on this medicine.
  • Remember to get your shot every 6 months. Write it down on your calendar.
  • If your doctor also told you to take calcium and vitamin D, remember to take them as well. They'll work with Prolia (Denosumab) to help protect your bones.
  • Can cause skin irritation, joint pain, limb pain, and back pain.
  • Let your doctor know if you start getting more infections.
  • Let your dentist know that you’re taking Prolia (Denosumab) since it can cause problems in the jaw bone after dental procedures.
Learn more
More about ReclastSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Reclast (zoledronate)?
Worth itNot sureNot worth it
More about ProliaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Prolia (denosumab)?
Worth itNot sureNot worth it