Compare Reclast vs. Prolia

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Prevents bone loss. Reclast (Zoledronate) is a first-choice treatment for osteoporosis and is available as a generic, but you have to see a doctor to get each dose.Prevents bone loss. Prolia (Denosumab) is an effective and convenient treatment for osteoporosis if other options haven’t worked or aren’t appropriate for you. There’re risks of some rare side effects, so make sure you're following up with your doctor regularly.
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Reviews & ratings
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Reviews for Reclast (Zoledronate)
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Side effects
  • Pain 20%
  • Fever 17%
  • Rash 16%
  • Chills 15%
  • Muscle pain 13%
  • Pain in jaw 12%
  • Fatigue 12%
  • Nausea 10%
  • Headache 9%
  • Joint pain 8%
More Reclast side effects »
  • Hypercholesterolemia 1%
  • Ankle and leg swelling 1%
  • Ear, nose, or throat infection 1%
  • Sciatica 1%
  • Bone pain 1%
  • Passing gas 1%
  • Muscle pain 1%
  • Heart-related chest pain 1%
  • Rash 1%
  • Pain in extremity 1%
More Prolia side effects »
How it works
Reclast (Zoledronate) is a bisphosphonate. It slows down osteoclasts, the cells that break down bone. This results in greater bone mass and lowers the possibility of fractures.Prolia (Denosumab) is a monoclonal antibody. It blocks a protein that sends signals to break down your bones, and therefore prevents bone loss.
Type of medication
BisphosphonatePrescription only
Monoclonal antibodyPrescription only
Available as
  • Injection
  • Injection
Used for (click to learn more)
Risk factors for serious side effects
    • Oral or dental surgery
    • Cancer
    • Poor oral hygiene
        Detailed Reclast (Zoledronate) risks & warnings »
        • Taking steroids
          • Kidney problems
          • Not taking calcium supplements
          • Taking other medicines that can lower calcium blood levels
          • History of hypoparathyroidism (low levels of parathyroid hormone)
          • Weak immune system
          • Taking medicines that block your immune system (such as transplant medications or steroids)
          • Oral or dental surgery
          • Cancer diagnosis
          • Taking steroids or chemotherapy
          • Poor oral hygiene
            Detailed Prolia (Denosumab) risks & warnings »
            Pregnancy category
            DFDA pregnancy category (Weigh risks vs. benefits)

            Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

            See the FDA package insert
            XFDA pregnancy category (Unsafe)

            Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

            See the FDA package insert
            No specific alcohol-related info.No specific alcohol-related info.
            No specific food-related info.No specific food-related info.
            Kidneys and liver
            No specific kidneys and liver-related info.No specific kidneys and liver-related info.
            No specific sex-related info.No specific sex-related info.
            No specific sleep-related info.No specific sleep-related info.
            No specific weight-related info.No specific weight-related info.
            Upsides and benefits
            • Available in generic.
            • You only have to take this once a year.
            • Prolia (Denosumab) is effective at preventing bone loss, making your bones stronger and lowering your chance of getting a fracture.
            • Only need to get an injection every 6 months, so you don’t have to remember to take something every day.
            Downsides and risks
            • You have to go to your doctor's office or an infusion center to get each dose by IV infusion.
            • Approved for women only after they’ve reached menopause. Don’t use this if you’re pregnant or planning to become pregnant.
            • Can lower blood calcium levels. You might need to take calcium supplements to prevent this.
            • Not available as a generic.
            Tips from our pharmacists for people taking the medication
            • Given as an intravenous infusion.
            • Eat normally and drink at least two glasses of liquid before your infusion.
            • Talk to your doctor if you develop swelling, pain, or a sore in your jaw.
            • Call your doctor if you develop pain in your hips, thighs or legs.
            • You can take acetaminophen (Tylenol) to lower fever and chills from the infusion.
            • If you have to have dental or oral surgery, tell your surgeon that you're taking this medication.
            • Drink plenty of liquids while you're on this medication.
            • Remember to get your shot every 6 months. Write it down on your calendar.
            • If your doctor also told you to take calcium and vitamin D, remember to take them as well. They'll work with Prolia (Denosumab) to help protect your bones.
            • Can cause skin irritation, joint pain, limb pain, and back pain.
            • Let your doctor know if you start getting more infections.
            • Let your dentist know that you’re taking Prolia (Denosumab) since it can cause problems in the jaw bone after dental procedures.
            Learn more
            More about ReclastSide effectsReviews & ratingsAlternativesFDA package insert
            More about ProliaSide effectsReviews & ratingsAlternativesFDA package insert