Compare Reclast vs. Prolia

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Reclast (zoledronate)

Prescription only

Prolia (Denosumab)

Prescription only
Prevents bone loss.

Reclast (zoledronate) is a good choice for osteoporosis if you aren't able to take bisphosphonates by mouth. It is available as a generic, but you have to see a doctor to get each dose.

4.1/ 7 average rating with 39 reviewsforReclast
Prevents bone loss.

Prolia (Denosumab) is an effective and convenient treatment for osteoporosis if other options haven’t worked or aren’t appropriate for you. There’re risks of some rare side effects, so make sure you're following up with your doctor regularly.

4.9/ 7 average rating with 15 reviewsforProlia
Upsides
  • Available in generic.
  • Depending on what you're using it for, you may only need to take it as a one-time dose, or every 1 to 2 years.
  • Prolia (Denosumab) is effective at preventing bone loss, making your bones stronger and lowering your chance of getting a fracture.
  • Only need to get an injection every 6 months, so you don’t have to remember to take something every day.
Downsides
  • You have to go to your doctor's office or an infusion center to get each dose by IV infusion.
  • It can't be used if you have really poor kidney function.
  • Joint pain and muscle pain are common side effects after the infusion.
  • Approved for women only after they’ve reached menopause. Don’t use this if you’re pregnant or planning to become pregnant.
  • Can lower blood calcium levels. You might need to take calcium supplements to prevent this.
  • Not available as a generic.
Used for
Dosage forms
  • Injection
  • Injection
Price
Lowest price near you
$27.04
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Lowest price near you
$2204.82
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Reviews
39 
28%
think this treatment is worth it
28%
think this treatment works well
36%
think this treatment is a hassle

Have you used Reclast (zoledronate)?

Leave a review
15 
33%
think this treatment is worth it
40%
think this treatment works well
27%
think this treatment is a hassle

Have you used Prolia (Denosumab)?

Leave a review
Side effects
10possible side effects
  • Muscle aches
    20%
  • Fatigue
    18%
  • Headache
    15%
  • Muscle pain
    12%
  • Pain
    12%
  • Chills
    10%
  • Influenza-like illness
    9%
  • Stomach pain
    8%
  • Shortness of breath
    7%
  • Feeling unwell
    7%
See more detailed side effects
10possible side effects
  • Back pain
    35%
  • Pain in extremity
    12%
  • Musculoskeletal pain
    8%
  • Hypercholesterolemia
    7%
  • Cystitis
    6%
  • Vertigo
    5%
  • Edema peripheral
    5%
  • Upper respiratory tract infection
    5%
  • Sciatica
    5%
  • Pneumonia
    4%
See more detailed side effects
Risks and warnings
  • Problems in the jawbone

    Oral or dental surgery

    ...and 2 more risk factors

  • Low calcium in the blood

    Low parathyroid hormone

    ...and 2 more risk factors

  • Kidney injury

    Kidney disease

    ...and 3 more risk factors

See more detailed risks and warnings
  • Leg bone fractures

    Taking steroids

  • Low calcium blood levels

    Kidney problems

    ...and 3 more risk factors

  • Infection

    Weak immune system

    ...and 1 more risk factors

  • Problems in the jaw bone

    Oral or dental surgery

    ...and 3 more risk factors

See more detailed risks and warnings