Compare Relafen vs. Acetaminophen with codeine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Relafen
(Nabumetone)

Tylenol #3
(Acetaminophen / Codeine)

Coming soon.Treats mild to moderate pain. Tylenol #3 (Acetaminophen / Codeine) is a good option to treat pain and cough as needed when over-the-counter medicines can't control the symptoms, but must make sure you don't take too much acetaminophen (Tylenol) to avoid liver problems or death.
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Reviews & ratings
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Reviews for Tylenol #3 (Acetaminophen / Codeine)
70%
+20% vs. Relafen (Nabumetone)
41%
9% vs. Relafen (Nabumetone)
9%
9% vs. Relafen (Nabumetone)
Side effects
RelafenAcetaminophen with codeine

We haven’t found good data for Relafen side effects.

FDA side effect reports for Relafen »

The Acetaminophen with codeine FDA package insert doesn’t have numbers about how common side effects are.

More about Acetaminophen with codeine side effects »
How it works
RelafenAcetaminophen with codeine
Coming soon.Tylenol #3 (Acetaminophen / Codeine) is a combination pain medicine. Codeine is an opioid (similar to morphine) that works in the brain to lower pain perception. Acetaminophen is a non-opioid pain reliever and fever reducer.
Type of medication
RelafenAcetaminophen with codeine
Coming soon.
Pain reliever
Acetaminophen (APAP)
Opioid
Prescription only
Available as
RelafenAcetaminophen with codeine
  • Pill
  • Pill
  • Liquid
Used for (click to learn more)
RelafenAcetaminophen with codeine
  • Osteoarthritis Rheumatoid arthritis
Risk factors for serious side effects
RelafenAcetaminophen with codeine
Coming soon.Coming soon.
Pregnancy category
RelafenAcetaminophen with codeine
CFDA pregnancy category (Weigh risks vs. benefits)

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
CFDA pregnancy category (Weigh risks vs. benefits)

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
Alcohol
No specific alcohol-related info.
  • Avoid alcohol.
Food
No specific food-related info.
  • Generally well tolerated by people, especially if taken with food to lower risk of stomach upset.
  • Take it with food to lower the chance of an upset stomach.
Kidneys and liver
No specific kidneys and liver-related info.No specific kidneys and liver-related info.
Sex
No specific sex-related info.No specific sex-related info.
Sleep
No specific sleep-related info.
  • Dizziness and drowsiness is common, but your body may adjust.
  • Can make you dizzy or drowsy.
Weight
No specific weight-related info.No specific weight-related info.
Upsides and benefits
RelafenAcetaminophen with codeine
Coming soon.
  • Combination pain medicine with an opioid component (codeine) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
  • Provides quick relieve for mild to moderate pain to improve quality of life.
  • Good for as-needed pain and control.
  • Generally well tolerated by people, especially if taken with food to lower risk of stomach upset.
  • Lower rates of misuse compared to pure opioid medicines.
  • Can help you fall asleep easier.
Downsides and risks
RelafenAcetaminophen with codeine
Coming soon.
  • Dizziness and drowsiness is common, but your body may adjust.
  • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Acetaminophen with codeine if you need.
  • All opioid containing medicines have the risk of physical dependence and possibility of withdrawal when used long-term.
  • The non-opioid part of Acetaminophen with codeine, acetaminophen (Tylenol), has a high risk of liver failure and death if you take more than the maximum daily dose. Be very careful.
  • Relies on the users to be aware of how much acetaminophen (Tylenol) they are using since it is a very common ingredient in many prescription and non-prescription pain medicines.
  • Avoid alcohol.
Tips from our pharmacists for people taking the medication
RelafenAcetaminophen with codeine
Coming soon.
  • This is a combination pain medication. It contains both an opioid medicine, and acetaminophen (Tylenol).
  • Starts working in 30 minutes.
  • Works best if you take it as soon as you start feeling pain.
  • Pain relief lasts 4-6 hours.
  • Can make you dizzy or drowsy.
  • Avoid activities need you to be fully alert until you know how it affects you.
  • Take it with food to lower the chance of an upset stomach.
  • Constipation is common and may not go away while you're taking this medicine. Drinking lots of water and using laxatives can help.
  • Don't take more than instructed to prevent liver damage.
  • Use it for the shortest time possible, and at the lowest dose possible, to lower your chance of becoming addicted.
  • Talk to your doctor if it doesn't help enough for your pain, or if the side effects are really bad.
Learn more
More about RelafenSide effectsReviews & ratingsFDA package insert
More about Acetaminophen with codeineSide effectsReviews & ratingsAlternativesFDA package insert