Compare Relafen vs. Norco

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Relafen
(Nabumetone)

Norco
(Hydrocodone / Acetaminophen)

Coming soon.Treats moderate to severe pain. Norco (Hydrocodone / Acetaminophen) is a good option to treat pain as needed when over-the-counter medicines can't control the symptoms, but must make sure you don't take too much acetaminophen (Tylenol) to avoid liver problems or death.
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Reviews & ratings
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Reviews for Norco (Hydrocodone / Acetaminophen)
67%
+17% vs. Relafen (Nabumetone)
44%
6% vs. Relafen (Nabumetone)
13%
13% vs. Relafen (Nabumetone)
Side effects
RelafenNorco

We haven’t found good data for Relafen side effects.

FDA side effect reports for Relafen »

The Norco FDA package insert doesn’t have numbers about how common side effects are.

More about Norco side effects »
How it works
RelafenNorco
Coming soon.Norco (Hydrocodone / Acetaminophen) is a combination pain medicine. Hydrocodone is an opioid (similar to morphine) that works in the brain to lower pain perception. Acetaminophen is a non-opioid pain reliever and fever reducer.
Type of medication
RelafenNorco
Coming soon.
Pain reliever
Opioid
Acetaminophen (APAP)
Prescription only
Available as
RelafenNorco
  • Pill
  • Pill
  • Oral solution
Used for (click to learn more)
RelafenNorco
  • Osteoarthritis Rheumatoid arthritis
Risk factors for serious side effects
RelafenNorco
Coming soon.
  • Current liver disease
  • Taking with alcohol
  • Taking other medicines with acetaminophen
  • Age 65 or greater
  • Higher dose
  • People with not enough thyroid hormones
  • History of lung problems
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Age 65 or greater
    • Long-term use of opioids in mother
    • Breastfeeding while taking Norco (Hydrocodone / Acetaminophen)
    • Taking more than the prescribed dose
    • Long-term use
    • History of drug abuse
    Detailed Norco (Hydrocodone / Acetaminophen) risks & warnings »
    Pregnancy category
    RelafenNorco
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    Alcohol
    No specific alcohol-related info.
    • Avoid alcohol.
    Food
    No specific food-related info.
    • Generally well tolerated by people, especially if taken with food to lower risk of stomach upset.
    • Take it with food to lower the chance of an upset stomach.
    Kidneys and liver
    No specific kidneys and liver-related info.No specific kidneys and liver-related info.
    Sex
    No specific sex-related info.No specific sex-related info.
    Sleep
    No specific sleep-related info.
    • Dizziness and drowsiness is common.
    • Can make you dizzy or drowsy. Avoid activities need you to be fully alert until you know how it affects you.
    Weight
    No specific weight-related info.
    • Hydrocodone, one of the medications in Norco (Hydrocodone / Acetaminophen) passes into breast milk. Women with a history of long-term opioid use increase the risk of neonatal withdrawal syndrome. Symptoms in the newborn include irritability, vomiting, diarrhea, tremor and lack of weight gain. Opioid withdrawal in infants is a life-threatening emergency and needs medical help right away.
    Upsides and benefits
    RelafenNorco
    Coming soon.
    • Combination pain medicine with an opiod component (hydrocodone) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
    • Provides quick relief for moderate to severe pain to improve quality of life.
    • Good for as-needed, short-term use, but may be helpful to manage more long-term pain problems if used at the appropriate doses and intervals.
    • Generally well tolerated by people, especially if taken with food to lower risk of stomach upset.
    • Lower rates of misuse compared to pure opioid medicines.
    • Can help you fall asleep easier.
    Downsides and risks
    RelafenNorco
    Coming soon.
    • Dizziness and drowsiness is common.
    • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Norco if you need.
    • All opioid containing medicines have the risk of physical dependence and possibility of withdrawal when used long-term.
    • The non-opioid part of Norco, acetaminophen (Tylenol), has a high risk of liver failure and death if you take more than the maximum daily dose. Be very careful.
    • Relies on the users to be aware of how much acetaminophen (Tylenol) they are using since it is a very common ingredient in many prescription and non-prescription pain medicines.
    • Avoid alcohol.
    Tips from our pharmacists for people taking the medication
    RelafenNorco
    Coming soon.
    • This is a combination pain medication. It contains both an opioid medicine and acetaminophen (Tylenol).
    • Works best if you take it as soon as you start feeling pain. Starts working in 30 minutes and pain relief lasts 4 to 6 hours.
    • Can make you dizzy or drowsy. Avoid activities need you to be fully alert until you know how it affects you.
    • Take it with food to lower the chance of an upset stomach.
    • Constipation is common and may not go away while you're taking this medicine. Drinking lots of water and using laxatives can help.
    • Don't take more than instructed to prevent liver damage.
    • Use it for the shortest time and at the lowest dose possible, to lower your chance of becoming addicted.
    • Talk to your doctor if it doesn't work well enough to relieve your pain, or if the side effects are really bad.
    Learn more
    More about RelafenSide effectsReviews & ratingsFDA package insert
    More about NorcoSide effectsReviews & ratingsAlternativesFDA package insert