Compare Relpax vs. Cafergot

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Relpax
(eletriptan)

Cafergot
(ergotamine / caffeine)

Treats migraine headaches. Relpax (eletriptan) is a first choice medicine to treat migraines, but it can be expensive.Treats migraine headaches. Cafergot (ergotamine / caffeine) can treat migraines, but you're more likely to have side effects.
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Reviews & ratings
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Have you used Relpax (eletriptan)?
Worth itNot sureNot worth it

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Have you used Cafergot (ergotamine / caffeine)?
Worth itNot sureNot worth it
Side effects
RelpaxCafergot
  • Headache 1%
  • Weakness 1%
  • Tingling or prickling sensation 1%
  • Indigestion 1%
  • Abdominal issues 1%
More Relpax side effects »

The Cafergot FDA package insert doesn’t have numbers about how common side effects are.

More about Cafergot side effects »
How it works
RelpaxCafergot
Relpax (eletriptan) is a triptan. Migraine headaches happen when blood vessels are too open and allow too much blood to the brain. Relpax (eletriptan) tightens the blood vessels, which relieves the pain.Cafergot (ergotamine / caffeine) is a combination of ergotamine and caffeine. It tightens the blood vessels in your brain to relieve the pain of your headaches.
Type of medication
RelpaxCafergot
Prescription only
Prescription only
Available as
RelpaxCafergot
  • Pill
  • Pill
  • Suppository
Used for
RelpaxCafergot
Risk factors for serious side effects
RelpaxCafergot
  • Heart rhythm problems
  • History of chest pain
  • Uncontrolled high blood pressure
  • History of a stroke
  • Using Relpax (eletriptan) for more than 10 days a month
  • Tricyclic antidepressants
  • Fentanyl
  • Tramadol
  • Buspirone
  • ADHD medicines
  • Triptans
  • Uncontrolled high blood pressure
  • High blood pressure
  • History of stroke
  • History of heart attack
Detailed Relpax (eletriptan) risks & warnings »
  • Overdosing Cafergot (ergotamine / caffeine)
  • Taking triptans (Imitrex, Axert, Maxalt, Amerge, Frova) for migraines
  • Taking Cafergot (ergotamine / caffeine) regularly for months
    Detailed Cafergot (ergotamine / caffeine) risks & warnings »
    Pregnancy

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    Upsides and benefits
    RelpaxCafergot
    • Relpax (eletriptan) works as well as other first choice medicines for migraines.
    • Relpax (eletriptan) comes in 2 different strengths.
    • Cafergot (ergotamine / caffeine) works better than other medicines if your migraines usually last more than 2 days or if you have more frequent migraines.
    Downsides and risks
    RelpaxCafergot
    • Relpax (eletriptan) is only available as a brand name.
    • Relpax (eletriptan) can cause dizziness and might make you more likely to fall.
    • If you have more than 3 migraines a month, Relpax (eletriptan) isn't a good choice because of its side effects.
    • Cafergot (ergotamine / caffeine) can't stop migraines from happening. They can only treat them.
    • Cafergot (ergotamine / caffeine) can only be used for migraines. It doesn't work for other types of headaches.
    • Smoking or using products that contain nicotine can make Cafergot (ergotamine / caffeine) less effective.
    Tips from our pharmacists for people taking the medication
    RelpaxCafergot
    • Relpax (eletriptan) can only treat a migraine that's already happening. Relpax (eletriptan) doesn't prevent migraines from starting.
    • Take Relpax (eletriptan) at the first sign of a migraine. You can take another dose if you don't feel better after 2 hours. Don't take more than 80 mg every 24 hours.
    • Relpax (eletriptan) can make you feel dizzy or tired when you first start taking it. Don't drive or do anything that requires concentration until you know how your body reacts to it.
    • If you find you're using the entire month's supply of Relpax (eletriptan) before your next refill, talk to your doctor to see if you should try something else.
    • Relpax (eletriptan) can cause nausea or tightness in the chest or throat. Talk to your doctor if it bothers you.
    • Take Cafergot (ergotamine / caffeine) as soon as you feel the migraine coming on.
    • You might be more sensitive to cold when you take Cafergot (ergotamine / caffeine) since it slows down the circulation of your blood in your skin, fingers and toes. Dress warmly.
    • If you have to take more than 6 tablets or 2 suppositories a day or 10 tablets or 5 suppositories in a week of Cafergot (ergotamine / caffeine), talk to your doctor.
    • Don't smoke tobacco if you're taking Cafergot (ergotamine / caffeine).
    • Keep the suppository of Cafergot (ergotamine / caffeine) in the fridge.
    Learn more
    More about RelpaxSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Relpax (eletriptan)?
    Worth itNot sureNot worth it
    More about CafergotSide effectsAlternativesFDA package insert
    Have you used Cafergot (ergotamine / caffeine)?
    Worth itNot sureNot worth it